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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Brief Report

Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells

Zeynep Özdemira Department of Pharmaceutical Chemistry, İnönü University, Malatya, TurkeyView further author information
,
Semra Utkub Department of Pharmaceutical Chemistry, Mersin University, Mersin, TurkeyView further author information
,
Bijo Mathewc Department of Pharmaceutical Chemistry, Division of Drug Design and Medicinal Chemistry Research Lab, Ahalia School of Pharmacy, Palakkad, IndiaCorrespondence[email protected]
View further author information
,
Simone Carradorid Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti, ItalyCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-8698-9440View further author information
ORCID Icon,
Giustino Orlandod Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti, ItalyView further author information
,
Simonetta Di Simoned Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti, ItalyView further author information
,
Mehmet Abdullah Alagöza Department of Pharmaceutical Chemistry, İnönü University, Malatya, TurkeyView further author information
,
Azime Berna Özçelike Department of Pharmaceutical Chemistry, Gazi University, Ankara, TurkeyView further author information
,
Mehtap Uysale Department of Pharmaceutical Chemistry, Gazi University, Ankara, Turkey;f Department of Pharmaceutical Chemistry, Erzincan Binali Yıldırım University, Erzincan, TurkeyView further author information
&
Claudio Ferranted Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti, ItalyView further author information
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Pages 1100-1109 | Received 12 Mar 2020, Accepted 08 Apr 2020, Published online: 22 Apr 2020

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Gasem Mohammad Abu-Taweel, Munjed M. Ibrahim, Sikandar Khan, Hamed M. Al-Saidi, Meshal Alshamrani, Fahad A. Alhumaydhi & Salman S. Alharthi. (2022) Medicinal Importance and Chemosensing Applications of Pyridine Derivatives: A Review. Critical Reviews in Analytical Chemistry 0:0, pages 1-18.
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Dan Su & Chunye Lv. (2021) Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway. Bioengineered 12:2, pages 11533-11543.
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Serena Veschi, Simone Carradori, Laura De Lellis, Rosalba Florio, Davide Brocco, Daniela Secci, Paolo Guglielmi, Mattia Spano, Anatoly P. Sobolev & Alessandro Cama. (2020) Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1331-1344.
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Articles from other publishers (10)

İrem Bozbey Merde, Gülce Taşkor Önel, Senem Akkoç, Zeynep Karaköy & Burçin Türkmenoğlu. (2023) Focusing on New Piperazinyl‐methyl‐3(2 H )pyridazinone Based Derivatives: Design, Synthesis, Anticancer Activity and Computational Studies . ChemistrySelect 8:25.
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Jyoti Singh, Vipan Kumar, Pragati Silakari & Sandeep Kumar. (2022) Pyridazinones: A versatile scaffold in the development of potential target‐based novel anticancer agents. Journal of Heterocyclic Chemistry 60:6, pages 929-949.
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Mohammad Asif, Mamdouh Allahyani, Mazen Mohammed Almehmadi & Ahad Amer Alsaiari. (2023) Applications and Biological Potential of Substituted Pyridazine Analogs in Medicinal and Agricultural Fields. Current Organic Chemistry 27:10, pages 814-820.
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Walaa Alharbi. (2022) Advancement and recent trends in seeking less toxic and more active anti-cancer drugs: Insights into thiourea based molecules. Main Group Chemistry 21:3, pages 885-901.
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Munira Alrooqi, Sikandar Khan, Fahad A. Alhumaydhi, Saeed A. Asiri, Meshal Alshamrani, Mutaib M. Mashraqi, Ahmad Alzamami, Asma M. Alshahrani & Afaf A. Aldahish. (2022) A Therapeutic Journey of Pyridine-based Heterocyclic Compounds as Potent Anticancer Agents: A Review (From 2017 to 2021). Anti-Cancer Agents in Medicinal Chemistry 22:15, pages 2775-2787.
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Rajesh Kumar, Seetha Harilal, Simone Carradori & Bijo Mathew. (2021) A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century. Current Medicinal Chemistry 28:14, pages 2657-2696.
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Mehmet Abdullah Alagöz, Zeynep Özdemir, Mehtap Uysal, Simone Carradori, Marialucia Gallorini, Alessia Ricci, Susi Zara & Bijo Mathew. (2021) Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker. Pharmaceuticals 14:3, pages 183.
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Muhammed Çeçen, Jong Min Oh, Zeynep Özdemir, Saliha Ebru Büyüktuncel, Mehtap Uysal, Mohamed A. Abdelgawad, Arafa Musa, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew & Hoon Kim. (2020) Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors. Molecules 25:22, pages 5371.
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Claudio Ferrante, Annalisa Chiavaroli, Paola Angelini, Roberto Venanzoni, Giancarlo Angeles Flores, Luigi Brunetti, Massimiliano Petrucci, Matteo Politi, Luigi Menghini, Sheila Leone, Lucia Recinella, Gokhan Zengin, Gunes Ak, Massimo Di Mascio, Francesco Bacchin & Giustino Orlando. (2020) Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts. Antibiotics 9:11, pages 783.
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Claudio Ferrante, Paola Angelini, Roberto Venanzoni, Giancarlo Angeles Flores, Bruno Tirillini, Lucia Recinella, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone, Simonetta Cristina Di Simone, Maria Chiara Ciferri, Gokhan Zengin, Gunes Ak, Luigi Menghini & Giustino Orlando. (2020) Antimicrobial, Antioxidant, and Antiproliferative Effects of Coronilla minima: An Unexplored Botanical Species. Antibiotics 9:9, pages 611.
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