Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
Submit an article Journal homepage
1,396
Views
12
CrossRef citations to date
0
Altmetric
Research Paper

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Andrea Medeirosa Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay;b Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, UruguayORCID Iconhttps://orcid.org/0000-0001-9677-8834View further author information
ORCID Icon,
Diego Beníteza Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, UruguayORCID Iconhttps://orcid.org/0000-0003-4639-8539View further author information
ORCID Icon,
Ricarda S. Kornc Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, GermanyView further author information
,
Vinicius C. Ferreirad Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, BrazilView further author information
,
Exequiel Barrerae Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, UruguayORCID Iconhttps://orcid.org/0000-0002-0388-3078View further author information
ORCID Icon,
Federico Carriónf Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, UruguayView further author information
,
Otto Pritschf Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay;g Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.View further author information
,
Sergio Pantanoe Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, UruguayORCID Iconhttps://orcid.org/0000-0001-6435-4543View further author information
ORCID Icon,
Conrad Kunickc Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, GermanyORCID Iconhttps://orcid.org/0000-0001-7041-5322View further author information
ORCID Icon,
Camila I. de Oliveirad Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, BrazilView further author information
,
Oliver C. F. Orbanc Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5506-789XView further author information
ORCID Icon &
Marcelo A. Cominia Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, UruguayCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5000-1333View further author information
ORCID Icon show all
Pages 1345-1358 | Received 10 Apr 2020, Accepted 02 Jun 2020, Published online: 26 Jun 2020

Citations (12)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No & Marcelo A. Comini. (2022) Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 912-929.
Read now

Articles from other publishers (11)

Irina Ihnatenko, Marco J. Müller, Oliver C. F. Orban, Jens C. Lindhof, Diego Benítez, Cecilia Ortíz, Estefanía Dibello, Leonardo L. Seidl, Marcelo A. Comini & Conrad Kunick. (2023) The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones. PLOS ONE 18:11, pages e0292946.
Crossref
Federico Carrión, Florencia Rammauro, Natalia Olivero‐Deibe, Martín Fló, María Magdalena Portela, Analía Lima, Rosario Durán, Otto Pritsch & Sergio Bianchi. (2023) Soluble SARS‐CoV ‐2 RBD and human ACE2 peptidase domain produced in Drosophila S2 cells show functions evoking virus–cell interface . Protein Science 32:8.
Crossref
Jens C. Lindhof, Irina Ihnatenko, Marco J. Müller, Oliver C. F. Orban, Cecilia Ortíz, Diego Benítez, Estefanía Dibello, Leonardo L. Seidl, Marcelo A. Comini & Conrad Kunick. (2023) Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction–Optimization Strategy Applied to Paullones. ChemMedChem 18:10.
Crossref
Kaio M. Santiago-Silva, Priscila G. Camargo & Marcelle L.F. Bispo. (2023) Promising Molecular Targets Related to Polyamine Biosynthesis in Drug Discovery against Leishmaniasis. Medicinal Chemistry 19:1, pages 2-9.
Crossref
Mercedes Alcón-Calderón, Héctor de Lucio, Juan Carlos García-Soriano, Alejandro Revuelto, Sonia de Castro, Celia López-Gutiérrez, Ana San-Félix, Ernesto Quesada, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz & Sonsoles Velázquez. (2022) Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry 243, pages 114675.
Crossref
Trong-Nhat Phan, Kyuho Paul Park, Diego Benítez, Marcelo A. Comini, David Shum & Joo Hwan No. (2022) Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening. Biochemical and Biophysical Research Communications 637, pages 308-313.
Crossref
Huseyin Istanbullu & Gulsah Bayraktar. 2022. Leishmaniasis - General Aspects of a Stigmatized Disease. Leishmaniasis - General Aspects of a Stigmatized Disease.
Ravikumar Akunuri, Manasa Vadakattu, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Mohammad Naiyaz Ahmad, Sushmitha Bujji, Swanand Vinayak Joshi, Arunava Dasgupta, Venkata Madhavi Yaddanapudi, Sidharth Chopra & Srinivas Nanduri. (2022) Synthesis and Antibacterial Evaluation of 3,4‐Dihydro‐1 H ‐benzo[ b ]azepine‐2,5‐dione Derivatives . ChemistrySelect 7:7.
Crossref
Marcelo A. Comini. 2022. Redox Chemistry and Biology of Thiols. Redox Chemistry and Biology of Thiols 555 584 .
Irina Ihnatenko, Peter G. Jones & Conrad Kunick. (2021) (E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one. Molbank 2021:4, pages M1293.
Crossref
Ahmed Mohamed Etman, Sherif Sabry Abdel Mageed, Mohamed Ahmed Ali & Mahmoud Abd El Monem El Hassab. (2021) Cyclin-Dependent Kinase as a Novel Therapeutic Target: An Endless Story. Current Chemical Biology 15:2, pages 139-162.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.