Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

Ahmed Elkamhawya College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea;b Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptCorrespondence[email protected] [email protected]

https://orcid.org/0000-0001-7398-6155 View further author information

Sora Paikc Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Hyeon Jeong Kimd Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;e Department of Biotechnology, Yonsei University, Seoul, Republic of KoreaView further author information

Jong-Hyun Parkd Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Ashwini M. Londhed Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;f Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of KoreaView further author information

Kyeong Leea College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of KoreaView further author information

Ae Nim Paed Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;f Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of KoreaView further author information

Ki Duk Parkd Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;f Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea;g KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of KoreaView further author information

Eun Joo Rohc Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;f Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of KoreaCorrespondence[email protected]
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Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

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Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

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