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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Potential anti-neuroinflammatory NF-кB inhibitors based on 3,4-dihydronaphthalen-1(2H)-one derivatives

Yue Suna The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, School of Pharmacy, Binzhou Medical University, Yantai, P. R. ChinaView further author information
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Yan-Qiu Zhoub School of Basic Medical Sciences, Binzhou Medical University, Yantai, P. R. ChinaView further author information
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Yin-Kai Liua The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, School of Pharmacy, Binzhou Medical University, Yantai, P. R. ChinaView further author information
,
Hong-Qin Zhangb School of Basic Medical Sciences, Binzhou Medical University, Yantai, P. R. ChinaView further author information
,
Gui-Ge Houa The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, School of Pharmacy, Binzhou Medical University, Yantai, P. R. ChinaView further author information
,
Qing-Guo Mengc School of Pharmacy, Yantai University, Yantai, P. R. ChinaCorrespondence[email protected]
View further author information
&
Yun Houb School of Basic Medical Sciences, Binzhou Medical University, Yantai, P. R. ChinaCorrespondence[email protected]
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Pages 1631-1640 | Received 28 Feb 2020, Accepted 29 Jul 2020, Published online: 11 Aug 2020

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J. Hemalatha, D. Reuben Jonathan, D. Angeline Shirmila, M. Krishna Priya, K. Laavanya & G. Usha. (2022) Structural and biological characterization of a biomolecule: (3E)-3-(2, 4, 5-trimethoxyphenyl) methylidene) - 2, 3-dihydro-4H-1-benzopyran-4-one. Phosphorus, Sulfur, and Silicon and the Related Elements 197:3, pages 263-268.
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Articles from other publishers (33)

Lu Yu, Qing-Guo Meng, Gui-Ge Hou, Yong-Jun Liu & Zi-Kai Geng. (2023) Crystal structure of 2-amino-4-(2-fluoro-3-(trifluoromethyl)phenyl)-9-methoxy-1,4,5,6-tetrahydrobenzo[ h ]quinazolin-3-ium chloride, C 20 H 18 ClF 4 N 3 O . Zeitschrift für Kristallographie - New Crystal Structures 238:6, pages 1161-1163.
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Yu-Lun Li, Qing-Guo Meng, Gui-Ge Hou & Zi-Kai Geng. (2023) Crystal structure of 2-((2-fluoro-4-(trifluoromethyl)phenyl)(hydroxy)methyl)-7-methoxy-3,4-dihydronaphthalen-1((2 H ))-one, C 19 H 16 F 4 O 3 . Zeitschrift für Kristallographie - New Crystal Structures 238:6, pages 1157-1159.
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Boye Jiang, Yun Hou, Feng-Lan Zhao & Qing-Guo Meng. (2023) Crystal structure of 7-hydroxy-3,4-dihydronaphthalen-1(2 H )-one, C 10 H 10 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 238:6, pages 1123-1125.
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Wei-Bin Yan, Wen-Xuan Li, Yue Zhang, Lu Yu, Yu-Lun Li, Yong-Jun Liu, Gui-Ge Hou, Qing-Guo Meng, Li-Ying Ma & Zi-Kai Geng. (2023) Treatment of rheumatoid arthritis with dissymmetric fluorine and pyridyl-substituted 3,5-bis(aryl)-4-piperidone derivatives by inhibition of NF-κB and MAPK activation. Arabian Journal of Chemistry, pages 105528.
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Xiao-Qing Yun, Yun Hou, Feng-Lan Zhao & Qing-Guo Meng. (2023) Crystal structure of 9-fluoro-4-(6-methoxypyridin-3-yl)-5,6-dihydrobenzo[ h ]quinazolin-2-amine, C 18 H 15 FN 4 O . Zeitschrift für Kristallographie - New Crystal Structures 0:0.
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Yang Yang, Zhong-Fei Gao, Gui-Ge Hou, Qing-Guo Meng & Yun Hou. (2023) Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization. European Journal of Medicinal Chemistry 259, pages 115688.
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Wen-Xuan Li, Qing-Guo Meng, Gui-Ge Hou, Yong-Jun Liu & Meng Zhang. (2023) Crystal structure of 2-amino-4-(2-fluoro-4-(trifluoromethyl)phenyl)-9-methoxy-1,4,5,6-tetrahydrobenzo[h]quinazolin-3-ium chloride, C 20 H 18 ClF 4 N 3 O . Zeitschrift für Kristallographie - New Crystal Structures 238:5, pages 1021-1023.
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Juan Zhang, Yun Hou, Feng-Lan Zhao & Qing-Guo Meng. (2023) Crystal structure of E -7-fluoro-2-(2-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 18 H 12 F 4 O . Zeitschrift für Kristallographie - New Crystal Structures 238:3, pages 525-527.
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Han-Lin Luo, Wen-Xuan Li, Xian-Yong Bai, Qing-Guo Meng & Yun Hou. (2023) Crystal structure of ( E )-7-fluoro-2-(4-morpholinobenzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 21 H 20 FNO 2 . Zeitschrift für Kristallographie - New Crystal Structures 238:3, pages 495-497.
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Shuai Lai, Yun Hou, Feng-Lan Zhao & Qing-Guo Meng. (2023) Crystal structure of ( E )-7-methoxy-2-(4-methoxy-2-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1( 2H )-one, C 20 H 17 F 3 O 3 . Zeitschrift für Kristallographie - New Crystal Structures 238:3, pages 445-447.
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Nicolai A. Aksenov, Dmitrii A. Aksenov, Daniil D. Ganusenko, Igor A. Kurenkov & Alexander V. Aksenov. (2023) A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso -Substitution of the Nitro Group . The Journal of Organic Chemistry 88:9, pages 5639-5651.
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Qin-Bing Qi, Wen-Xuan Li, Gui-Ge Hou & Cheng-Bo Li. (2023) Crystal structure of ( E )-7-bromo-2-(4-(4-methylpiperazin-1-yl)benzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 22 H 23 BrN 2 O . Zeitschrift für Kristallographie - New Crystal Structures 238:2, pages 235-237.
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Rong-Kai Li, Chun-Hua Wang, Gui-Ge Hou & Cheng-Bo Li. (2023) Crystal structure of 9-(2-chloroethoxy)-4-(4-methoxy-3-(trifluoromethyl)phenyl)- 5,6-dihydrobenzo[ h ]quinazolin-2-amine, C 22 H 19 ClF 3 N 3 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 238:2, pages 243-245.
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Xiao-Qian Yuan, Le-Hui Zhao, Jia-Jing Zhang & Gui-Ge Hou. (2023) Crystal structure of ( E )-7-methoxy-2-(4-morpholinobenzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 22 H 23 NO 3 . Zeitschrift für Kristallographie - New Crystal Structures 238:2, pages 363-365.
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Yi-Bin Liu, Yang-Rong Xu, Wen-Shui Wang, Sheng Jiang, Feng-Lan Zhao & Qing-Guo Meng. (2023) Crystal structure of E -7-fluoro-2-(4-methoxy-3-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 19 H 14 F 4 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 238:2, pages 223-225.
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Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei & Ling Zhao. (2023) α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. Journal of Neuroinflammation 20:1.
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Ming-Zhu Luan, Xiao-Fan Zhang, Yang Yang, Qing-Guo Meng & Gui-Ge Hou. (2023) Anti-inflammatory activity of fluorine-substituted benzo[h]quinazoline-2-amine derivatives as NF-κB inhibitors. Bioorganic Chemistry 132, pages 106360.
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Haoyu Wang, Haifan Wang, Heng Huang, Zhigang Qu, Dong Ma, Xiaoqian Dang & Quanyu Dong. (2022) Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome. Cells 11:18, pages 2809.
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Hongwu Li, Xiaofei Yan & Shaowu Ou. (2022) Correlation of the prognostic value of FNDC4 in glioblastoma with macrophage polarization. Cancer Cell International 22:1.
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Xiao-Fan Zhang, Ming-Zhu Luan, Wei-Bin Yan, Feng-Lan Zhao, Yun Hou, Gui-Ge Hou & Qing-Guo Meng. (2022) Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells. European Journal of Medicinal Chemistry 235, pages 114322.
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Jia Song, Feng-Lan Zhao, Qi-bao Wang & Qing-Guo Meng. (2022) Crystal structure of ( E )-7-fluoro-2-(3-fluorobenzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 17 H 12 F 2 O 1 . Zeitschrift für Kristallographie - New Crystal Structures 237:1, pages 55-57.
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Sheng-Nan Zhang, Feng-Lan Zhao & Qing-Guo Meng. (2022) Crystal structure of ( E )-7-hydroxy-2-((6-methoxypyridin-3-yl)methylene)-3, 4-dihydronaphthalen-1(2 H )-one, C 17 H 15 NO 3 . Zeitschrift für Kristallographie - New Crystal Structures 237:1, pages 1-3.
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Xiang-Yi Su, Xiao-Fan Zhang, Qing-Guo Meng & Hong-Juan Li. (2021) Crystal structure of ( E )-7-fluoro-2-((6-methoxypyridin-3-yl)methylene)-3,4-dihydronaphthalen-1(2 H )-one, C 17 H 14 FNO 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:5, pages 1101-1103.
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Jia-Jia Sun, Xiao-Fan Zhang, Qing-Guo Meng, Hong-Juan Li & Chun-Hua Wang. (2021) Crystal structure and anti-inflammatory activity of ( E )-7-fluoro-2-((5-methoxypyridin-3-yl)methylene)-3,4-dihydronaphthalen-1(2 H )-one, C 17 H 14 FNO 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:5, pages 1097-1099.
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Lei Wang, Qing-Guo Meng, Nan Jiang, Lin Wei & Chun-Hua Wang. (2021) Crystal structure of ( E )-7-methoxy-2-((6-methoxypyridin-3-yl)methylene)-3,4-dihydronaphthalen-1(2 H )-one, C 18 H 17 NO 3 . Zeitschrift für Kristallographie - New Crystal Structures 236:5, pages 1069-1071.
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Qing-Guo Meng, Sheng-Nan Zhao, Zhong-Hao Sun, Guang-Zhi Shan & Qing-Guo Meng. (2021) Crystal structure of ( E )-7-fluoro-2-(4-methoxy-2-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2 H )-one, C 19 H 14 F 4 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:5, pages 1059-1061.
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Lei Wang, Qing-Guo Meng & Gui-Ge Hou. (2021) Crystal structure of ( E )-7-methoxy-2-((6-methoxypyridin-2-yl)methylene)-tetralone, C 18 H 17 NO 3 . Zeitschrift für Kristallographie - New Crystal Structures 236:5, pages 1023-1025.
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Xiao-Fan Zhang & Qing-Guo Meng. (2021) Crystal structure of ( E )-2-((2-methoxy-3-pyridyl)methylene)-7-fluoro-3,4-dihydronaphthalen-1(2 H )-one, C 17 H 14 FNO 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:3, pages 507-509.
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Beata Tylińska, Benita Wiatrak, Żaneta Czyżnikowska, Aneta Cieśla-Niechwiadowicz, Elżbieta Gębarowska & Anna Janicka-Kłos. (2021) Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study. International Journal of Molecular Sciences 22:8, pages 3825.
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Ming-Zhu Luan & Qing-Guo Meng. (2021) Crystal structure of ( E )-7-methoxy-2-((5-methoxypyridin-3-yl)methylene)-3,4- dihydronaphthalen-1(2 H )-one, C 18 H 17 NO 3 . Zeitschrift für Kristallographie - New Crystal Structures 236:2, pages 387-389.
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Ming-Zhu Luan, Hui-Yun Wang, Mei Zhang, Jia Song, Yang-Rong Xu, Feng-Lan Zhao & Qing-Guo Meng. (2021) Crystal structure of ( E )-2-(4-fluoro-2-(trifluoromethyl)benzylidene)-7-methoxy-3,4-dihydronaphthalen-1(2 H )-one, C 19 H 14 F 4 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:1, pages 245-247.
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Xiao-Fan Zhang, Hui-yun Wang, Sheng-Nan Zhao, Sheng-Nan Zhang, Feng-Lan Zhao & Qing-Guo Meng. (2021) Crystal structure of ( E )-2-(4-fluoro-3-(trifluoromethyl)benzylidene)-7-methoxy-3,4-dihydronaphthalen-1(2 H )-one, C 19 H 14 F 4 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:1, pages 47-49.
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Ming-Zhu Luan, Hui-yun Wang, Mei Zhang, Jia Song, Gui-Ge Hou, Feng-Lan Zhao & Qing-Guo Meng. (2021) Crystal structure of ( E )-2-(3,5-bis(trifluoromethyl)benzylidene)-7-methoxy-3,4-dihydronaphthalen- 1(2 H )-one, C 20 H 14 F 6 O 2 . Zeitschrift für Kristallographie - New Crystal Structures 236:1, pages 61-63.
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