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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

Ulviye Acar Çevika Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey;b Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyCorrespondence[email protected],
ORCID Iconhttps://orcid.org/0000-0003-1879-1034View further author information
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Begüm Nurpelin Sağlıka Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey;b Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0002-0151-6266View further author information
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Derya Osmaniyea Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey;b Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0002-0499-436XView further author information
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Serkan Leventa Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey;b Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0003-3692-163XView further author information
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Betül Kaya Çavuşoğluc Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Zonguldak Bülent Ecevit University, Zonguldak, TurkeyORCID Iconhttps://orcid.org/0000-0001-8270-4949View further author information
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Abdullah Burak Karadumand Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0002-0434-1334View further author information
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Özlem Atlı Eklioğlud Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0002-6131-3399View further author information
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Yusuf Özkaya Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey;b Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0001-8815-153XView further author information
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Zafer Asım Kaplancıklıa Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0003-2252-0923View further author information
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Pages 1657-1673 | Received 17 May 2020, Accepted 28 Jul 2020, Published online: 19 Aug 2020

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Ulviye Acar Çevik, Ismail Celik, Ayşen Işık, Iqrar Ahmad, Harun Patel, Yusuf Özkay & Zafer Asım Kaplancıklı. (2023) Design, synthesis, molecular modeling, DFT, ADME and biological evaluation studies of some new 1,3,4-oxadiazole linked benzimidazoles as anticancer agents and aromatase inhibitors. Journal of Biomolecular Structure and Dynamics 41:5, pages 1944-1958.
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Ulviye Acar Çevik, Ismail Celik, Ayşen Işık, Ülküye Dudu Gül, Gizem Bayazıt, Hayrani Eren Bostancı, Yusuf Özkay & Zafer Asım Kaplancıklı. (2023) Synthesis, and docking studies of novel tetrazole-S-alkyl derivatives as antimicrobial agents. Phosphorus, Sulfur, and Silicon and the Related Elements 198:2, pages 137-144.
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Fatih Tok, Murat Kaya, Hülya Karaca & Bedia Koçyiğit-Kaymakçıoğlu. (2022) Synthesis of some novel 1,3,4-oxadiazole derivatives and evaluation of their antimicrobial activity. Synthetic Communications 52:6, pages 926-935.
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Articles from other publishers (18)

Shankaraiah Ambala, Vishnu Thumma, Veerabhadraiah Mallikanti, Shalini Aitha, Raghavender Matta & Jalapathi Pochampally. (2023) Design, Synthesis, and Cytotoxicity of Some New Benzimidazole‐Piperazine Conjugate Analogues Against Human Breast Adenocarcinoma. ChemistrySelect 8:31.
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Sneha Venugopal, Balwinder Kaur, Anil Verma, Pankaj Wadhwa, Muskan Magan, Sharwan Hudda & Violina Kakoty. (2023) Recent advances of benzimidazole as anticancer agents. Chemical Biology & Drug Design 102:2, pages 357-376.
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Bayan Zoatier, Metin Yildirim, Mehmet Abdullah Alagoz, Derya Yetkin, Burcin Turkmenoglu, Serdar Burmaoglu & Oztekin Algul. (2023) N-(benzazol-2-yl)-2-substituted phenylacetamide derivatives: Design, synthesis and biological evaluation against MCF7 breast cancer cell line. Journal of Molecular Structure 1285, pages 135513.
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Gökay Çetiner, Ulviye Acar Çevik, Ismail Celik, Hayrani Eren Bostancı, Yusuf Özkay & Zafer Asım Kaplancıklı. (2023) New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies. Journal of Molecular Structure 1278, pages 134920.
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Mohamed Abdoul-Hakim, Khadija El Idrissi, Abdellah Zeroual & Hocine Garmes. (2023) Investigation of the solvent effect, regioselectivity, and the mechanism of the cycloaddition reaction between 2-chlorobenzimidazole and benzonitrile oxide. Chemistry of Heterocyclic Compounds 59:3, pages 155-164.
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Fatma Fouad Hagar, Samar H. Abbas, Dalia Abdelhamid, Hesham A. M. Gomaa, Bahaa G. M. Youssif & Mohamed Abdel‐Aziz. (2022) New 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids as potent antiproliferative agents. Archiv der Pharmazie 356:2.
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Hoang-Phuc Nguyen, Thi Kim Chi Huynh, Khac-Minh Thai & Thi-Kim-Dung Hoang. (2022) QSAR modeling and molecular docking studies on benzimidazole derivatives as anticancer agents. Vietnam Journal of Science and Technology 60:6, pages 993-1004.
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Hayrani Eren BOSTANCI & Ulviye ACAR ÇEVİK. (2022) Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal 43:4, pages 590-593.
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Ayşen IŞIK, Ulviye Acar Çevik, Ismail Çelik, Hayrani Eren Bostancı, Arzu Karayel, Gülsüm Gündoğdu, Ufuk Ince, Ahmet Koçak, Yusuf Özkay & Zafer Asım Kaplancıklı. (2022) Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies. Journal of Molecular Structure 1270, pages 133946.
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Mehmet Murat Kisla & Zeynep Ates-Alagoz. (2022) Benzimidazoles Against Certain Breast Cancer Drug Targets: A Review. Mini-Reviews in Medicinal Chemistry 22:19, pages 2463-2477.
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Kaan Küçükoğlu, Ulviye Acar Çevik, Hayrunnisa Nadaroglu, Ismail Celik, Ayşen Işık, Hayrani Eren Bostancı, Yusuf Özkay & Zafer Asım Kaplancıklı. (2022) Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects. Medicinal Chemistry Research 31:10, pages 1771-1782.
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Lian‐Shun Feng, Wen‐Qi Su, Jin‐Bo Cheng, Tao Xiao, Hong‐Ze Li, De‐An Chen & Zhi‐Liu Zhang. (2022) Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021). Archiv der Pharmazie 355:6.
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Ulviye Acar Çevik, Ismail Celik, Jaime Mella, Marco Mellado, Yusuf Özkay & Zafer Asım Kaplancıklı. (2022) Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor. ACS Omega 7:18, pages 16152-16163.
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Hiram Hernández-López, Christian Jairo Tejada-Rodríguez & Socorro Leyva-Ramos. (2022) A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity. Mini-Reviews in Medicinal Chemistry 22:9, pages 1268-1280.
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Mohamed Jawed Ahsan. (2022) 1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy. Mini-Reviews in Medicinal Chemistry 22:1, pages 164-197.
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Garvit Satija, Barkha Sharma, Anish Madan, Ashif Iqubal, Mohammad Shaquiquzzaman, Mymoona Akhter, Suhel Parvez, Mohammad Ahmed Khan & Mohammad Mumtaz Alam. (2021) Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets. Journal of Heterocyclic Chemistry 59:1, pages 22-66.
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PV Ershov & AS Makarova. (2021) Current trends in anticancer drug prototype in vitro pharmacology: bibliometric analysis 2019–2021. Medicine of Extreme Situations:2021(3).
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Bita Mohtat, Milad Bazaz Rastkar, Gholam Bagheri Marandi & Hoorieh Djahaniani. (2021) Four-Component Synthesis of Functionalized 1,3,4-Oxadiazole Derivatives Bearing the 2-Amino benzothiazole Moiety. HETEROCYCLES 102:10, pages 1969.
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