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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

Loghman Firoozpoura Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, IranCorrespondence[email protected]
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,
Lixin Gaob National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Setareh Moghimia Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, IranView further author information
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Parvin Pasalarc Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranView further author information
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Jamshid Davoodid Institute of Biochemistry and Biophysics, University of Tehran, Tehran, IranView further author information
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Ming-Wei Wangb National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Zahra Rezaeie Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranView further author information
,
Armin Dadgarf Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranView further author information
,
Hoda Yahyavia Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, IranView further author information
,
Massoud Amanloue Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranORCID Iconhttps://orcid.org/0000-0002-8559-1668View further author information
ORCID Icon &
Alireza Foroumadia Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran;e Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranCorrespondence[email protected]
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Pages 1674-1684 | Received 27 Aug 2019, Accepted 07 Aug 2020, Published online: 25 Aug 2020

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Mai H. ElNaggar, Abdullah A. Elgazar, Ghada Gamal, Shimaa M. Hamed, Zainab M. Elsayed, Mohamed K. El-Ashrey, Amira Abood, Mahmoud A. El Hassab, Ahmed M. Soliman, Ramadan A. El-Domany, Farid A. Badria, Claudiu T. Supuran & Wagdy M. Eldehna. (2023) Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Hadeer K. Swedan, Asmaa E. Kassab, Ehab M. Gedawy & Salwa E. Elmeligie. (2023) Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 118-137.
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Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran & Nada M. Mohamed. (2022) Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 701-717.
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Reihane Ghomashi, Shakila Ghomashi, Hamidreza Aghaei, Samineh Massah & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part C: Multicomponent Sulfonamide Hybrids. Current Medicinal Chemistry 30:37, pages 4181-4255.
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Firouz Matloubi Moghaddam, Nouraddin Hosseinzadeh, Fatemeh Safari & Alireza Foroumadi. (2022) Ultrasound‐promoted 1, 3‐dipolar cycloaddition of azomethine yields for synthesis of dispiropyrrolidineoxindole derivatives in hexyltriphenylphosphonium bromide as an ionic liquid, and the evaluation of their anti‐cancer activity . Journal of Heterocyclic Chemistry 60:3, pages 416-422.
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Camilla Malatini, Carlos Carbajales, Mariángel Luna, Osvaldo Beltrán, Manuel Amorín, Christian F. Masaguer, José M. Blanco, Silvia Barbosa, Pablo Taboada & Alberto Coelho. (2023) 3D-Printing of Capsule Devices as Compartmentalization Tools for Supported Reagents in the Search of Antiproliferative Isatins. Pharmaceuticals 16:2, pages 310.
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Dening Chang, Yanda Li, Yuxuan Chen, Xiaojing Wang, Dejin Zang & Teng Liu. (2022) Polyoxometalate-based nanocomposites for antitumor and antibacterial applications. Nanoscale Advances 4:18, pages 3689-3706.
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Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy & Osama M. Ahmed. (2022) Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways. Antioxidants 11:4, pages 699.
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Srinivasan Bargavi, Siddan Gouthaman, Madurai Sugunalakshmi & Srinivasakannan Lakshmi. (2021) Synthesis, spectroscopic investigation, crystal structure analysis, quantum chemical study, biological activity and molecular docking of three isatin derivatives. Acta Crystallographica Section C Structural Chemistry 77:6, pages 299-311.
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Saira Khatoon, Aiman Aroosh, Arshad Islam, Saima Kalsoom, Faisal Ahmad, Shahid Hameed, Sumra Wajid Abbasi, Masoom Yasinzai & Muhammad Moazzam Naseer. (2021) Novel coumarin-isatin hybrids as potent antileishmanial agents: Synthesis, in silico and in vitro evaluations. Bioorganic Chemistry 110, pages 104816.
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Lucas Beroske, Tim Van den Wyngaert, Sigrid Stroobants, Pieter Van der Veken & Filipe Elvas. (2021) Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers. International Journal of Molecular Sciences 22:8, pages 3948.
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Shunhong Chen, Shengxin Guo, Feng He, Yingxia Zhang, Zengxue Wu & Jian Wu. (2020) DBU Catalyzed Phospho-Aldol-Brook Rearrangement for Rapid Preparation of α-Phosphates Amide in Solvent-Free Conditions. Catalysts 10:12, pages 1445.
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