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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 36, 2021 - Issue 1
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Review Article

The role of mTOR in age-related diseases

Zofia ChrienovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, CzechiaView further author information
,
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, CzechiaORCID Iconhttps://orcid.org/0000-0003-0281-246XView further author information
ORCID Icon &
Kamil KucaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, CzechiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9664-1109View further author information
ORCID Icon
Pages 1678-1692 | Received 19 Jan 2021, Accepted 18 Jun 2021, Published online: 26 Jul 2021

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Sheng Hu, Yijie Zhang, Chenming Qiu & Ying Li. (2023) RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling. Clinical and Experimental Hypertension 45:1.
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Ashley Payne, Equar Taka, Getinet M. Adinew & Karam F. A. Soliman. (2023) Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells. Brain Sciences 13:4, pages 632.
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Sanjeev K. Ganesh & C. Subathra Devi. (2023) Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus. Molecular Biology Reports 50:4, pages 3815-3833.
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Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Marek Bajda, Milan Reinis, Romana Mikyskova, Ondrej Novotny, Rudolf Andrys, Adam Skarka, Pavla Vasicova, Josef Novak, Martin Valis, Kamil Kuca, Zdenek Hodny & Eugenie Nepovimova. (2022) Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Frontiers in Aging Neuroscience 14.
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Mahmoud Al-Azab, Mohammed Safi, Elina Idiiatullina, Fadhl Al-Shaebi & Mohamed Y. Zaky. (2022) Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting. Cellular & Molecular Biology Letters 27:1.
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Fernanda D. Botelho, Eugenie Nepovimova, Kuca Kamil & Tanos C. C. Franca. (2022) Virtual screening and molecular dynamic study of potential new binders to mTOR. Journal of Molecular Modeling 28:10.
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Patrik Oleksak, Eugenie Nepovimova, Zofia Chrienova, Kamil Musilek, Jiri Patocka & Kamil Kuca. (2022) Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021). European Journal of Medicinal Chemistry 238, pages 114498.
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Soheila Montazersaheb, Ali Ehsani, Ezzatollah Fathi & Raheleh Farahzadi. (2022) Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical Prospect. Oxidative Medicine and Cellular Longevity 2022, pages 1-13.
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Julian M. Carosi, Célia Fourrier, Julien Bensalem & Timothy J. Sargeant. (2021) The mTOR–lysosome axis at the centre of ageing. FEBS Open Bio 12:4, pages 739-757.
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Hua-Chuan Zheng, Hang Xue, Yu-Zi Jin, Hua-Mao Jiang & Zheng-Guo Cui. (2022) The Oncogenic Effects, Pathways, and Target Molecules of JC Polyoma Virus T Antigen in Cancer Cells. Frontiers in Oncology 12.
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Lanlan Tang, Yu Fu, Jiarun Song, Taibing Hu, Kun Li & Zhi Li. (2022) mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models. Pharmacology Research & Perspectives 10:1.
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Karen Schindler. (2021) Inhibition of BIN2 extends reproductive lifespan. Nature Aging 1:11, pages 977-979.
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Marti Cadena Sandoval, Alexander Martin Heberle, Ulrike Rehbein, Cecilia Barile, José Miguel Ramos Pittol & Kathrin Thedieck. (2021) mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases. Frontiers in Aging 2.
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