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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 36, 2021 - Issue 1
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Brief Report

Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease

Xiaoying Jianga College of Pharmaceutical Science, Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China;b College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, China;c College of Chemistry and Chemical Engineering, Central South University, Changsha, ChinaView further author information
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Jianan Guoa College of Pharmaceutical Science, Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, ChinaView further author information
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Changjun Zhanga College of Pharmaceutical Science, Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, ChinaView further author information
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Jinping Gua College of Pharmaceutical Science, Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, ChinaView further author information
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Tao Zhoud School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, ChinaView further author information
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Renren Baie School of Pharmacy, Hangzhou Normal University, Hangzhou, China;f Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaCorrespondence[email protected] [email protected]
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Yuanyuan Xiea College of Pharmaceutical Science, Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, ChinaCorrespondence[email protected]
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Pages 2045-2054 | Received 06 Jul 2021, Accepted 03 Sep 2021, Published online: 04 Oct 2021

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Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou & Yuanyuan Xie. (2023) Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 100-117.
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Articles from other publishers (2)

Xiaoying Jiang, Kaiyu Wu, Xiang‐Yang Ye, Tian Xie, Pengfei Zhang, Benjamin E. Blass & Renren Bai. (2023) Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis. Medicinal Research Reviews 43:4, pages 872-896.
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Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie & Renren Bai. (2022) HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids. Bioorganic Chemistry 122, pages 105724.
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