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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Brief Report

Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma

Renren Baia School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaCorrespondence[email protected] [email protected]
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Junlong Zhua School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaView further author information
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Ziqiang Baia School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaView further author information
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Qing Maoa School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaView further author information
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Yingqian Zhanga School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaView further author information
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Zi Huia School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaView further author information
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Xinyu Luoa School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaView further author information
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Xiang-Yang Yea School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3739-0930View further author information
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Tian Xiea School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China;b Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaCorrespondence[email protected]
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Pages 379-385 | Received 25 Oct 2021, Accepted 05 Dec 2021, Published online: 10 Jan 2022

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Yuan Gao, Jilong Duan, Xiawen Dang, Yinghui Yuan, Yu Wang, Xingrui He, Renren Bai, Xiang-Yang Ye & Tian Xie. (2023) Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Zhenhao Chen, Yunpeng Sun, Yongyue Wang, Lingyi Kong & Jun Luo. (2023) Two new sesquiterpenoids from the roots of Sarcandra glabra. Natural Product Research 37:20, pages 3505-3511.
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Yuan Gao, Nian-Dong Mao, Hao Che, Li Xu, Renren Bai, Li-Wei Wang, Xiang-Yang Ye & Tian Xie. (2022) Novel hydroxyl carboximates derived from β-elemene: design, synthesis and anti-tumour activities evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2403-2416.
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Articles from other publishers (5)

Junlong Zhu, Xiaoying Jiang, Xinyu Luo, Rui Zhao, Junjie Li, Hong Cai, Xiang‐Yang Ye, Renren Bai & Tian Xie. (2023) Combination of chemotherapy and gaseous signaling molecular therapy: Novel β ‐elemene nitric oxide donor derivatives against leukemia . Drug Development Research.
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Muhammad Abu Yousef & Ryosuke Matsubara. (2023) Recent progress in synthesis and application of furoxan. RSC Advances 13:8, pages 5228-5248.
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Xiaoying Jiang, Xiang-Yang Ye & Tian Xie. 2023. Elemene Antitumor Drugs. Elemene Antitumor Drugs 259 280 .
Xiang Qi, Songwei Jiang, Zi Hui, Yuan Gao, Yang Ye, Frédéric Lirussi, Carmen Garrido, Li Xu, Xingrui He, Renren Bai, Xiang-Yang Ye & Tian Xie. (2022) Design, synthesis and antitumor efficacy evaluation of a series of novel β-elemene-based macrocycles. Bioorganic & Medicinal Chemistry 74, pages 117049.
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Yang Ye, Xiang Qi, Bing Xu, Ying Lin, Huan Xiang, Liang Zou, Xiang-Yang Ye & Tian Xie. (2022) Nickel-catalyzed cross-electrophile allylation of vinyl bromides and the modification of anti-tumour natural medicine β-elemene. Chemical Science 13:23, pages 6959-6966.
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