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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Papers

Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers

Heba S. A. Elzahabia Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7023-6364View further author information
ORCID Icon,
Eman S. Nossiera Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptView further author information
,
Rania A. Alasfourya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptView further author information
,
May El-Manawatyb Pharmacognosy Department, National Research Centre, Dokki, Cairo, EgyptView further author information
,
Sara M. Sayedc Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptView further author information
,
Eslam B. Elkaeedd Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaView further author information
,
Ahmed M. Metwalye Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt;f Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptView further author information
,
Mohamed Hagrasg Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
&
Ibrahim H. Eissah Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6955-2263View further author information
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Pages 1053-1076 | Received 12 Jan 2022, Accepted 01 Apr 2022, Published online: 12 Jul 2022

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Esraa A. Abdelsalam, Amer Ali Abd El-Hafeez, Wagdy M. Eldehna, Mahmoud A. El Hassab, Hala Mohamed M. Marzouk, Mahmoud M. Elaasser, Nageh A. Abou Taleb, Kamilia M. Amin, Hatem A. Abdel-Aziz, Pradipta Ghosh & Sherif F. Hammad. (2022) Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2265-2282.
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Articles from other publishers (7)

Fatma A. M. Mohamed, Saleha Y. M. Alakilli, Eman Fawzy El Azab, Faris A. M. Baawad, Esraa Ibrahim A. Shaaban, Heba Abu Alrub, Omnia Hendawy, Hesham A. M. Gomaa, Adel G. Bakr, Mostafa H. Abdelrahman, Laurent Trembleau, Anber F. Mohammed & Bahaa G. M. Youssif. (2023) Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action. RSC Medicinal Chemistry 14:4, pages 734-744.
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Mohamed M. Hammouda, Marwa M. Rashed, Khaled M. Elattar & Amany M. A. Osman. (2023) Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts. RSC Advances 13:17, pages 11600-11634.
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Ibrahim H. Eissa, Reda G. Yousef, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mohamed S. Alesawy, Hazem Elkady & Ahmed M. Metwaly. (2023) Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach. PLOS ONE 18:3, pages e0282586.
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Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Bshra A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Eslam B. Elkaeed & Ahmed M. Metwaly. (2023) A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study. Life 13:1, pages 191.
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Eman S. Nossier, Rania A. Alasfoury, Mohamed Hagras, May El-Manawaty, Sara M. Sayed, Ibrahim M. Ibrahim, Hazem Elkady, Ibrahim H. Eissa & Heba S.A. Elzahabi. (2022) Modified pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation. Journal of Molecular Structure 1270, pages 133971.
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Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mohamed Alswah, Heba S. A. Elzahabi, Ahmed M. Metwaly & Ibrahim H. Eissa. (2022) A New Theobromine-Based EGFRWT and EGFRT790M Inhibitor and Apoptosis Inducer: Design, Semi-Synthesis, Docking, DFT, MD Simulations, and In Vitro Studies. Processes 10:11, pages 2290.
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Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2022) New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies. Molecules 27:18, pages 5859.
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