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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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PROTACs for BRDs proteins in cancer therapy: a review

Chao Wanga The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, PR ChinaCorrespondence[email protected]
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Yujing Zhangb The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao University, Qingdao, PR China;c School of Pharmacy, Qingdao University, Qingdao, PR ChinaCorrespondence[email protected]
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Shanbo Yanga The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, PR ChinaView further author information
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Wujun Chena The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, PR ChinaCorrespondence[email protected]
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Dongming Xinga The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, PR China;d School of Life Sciences, Tsinghua University, Beijing, PR ChinaCorrespondence[email protected]
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Pages 1694-1703 | Received 07 Dec 2021, Accepted 18 May 2022, Published online: 14 Jun 2022

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Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao & Shengzheng Wang. (2023) Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Essam M. Eliwa, Walid E. Elgammal, Amany Belal, Mohammed A. S. Abourehab, Shimaa M. Abd El-Gilil, Ahmed B. M. Mehany & Gameel A. M. Elhagali. (2023) Cu(II)-Promoted the Chemical Synthesis of New Azines-Based Naphthalene Scaffold as In Vitro Potent Mushroom Tyrosinase Inhibitors and Evaluation of Their Antiproliferative Activity. Polycyclic Aromatic Compounds 43:7, pages 6018-6045.
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Wei Yang, Huining Peng, Yong Huang, Zhiyun Peng & Guangcheng Wang. (2022) Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2530-2539.
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Articles from other publishers (8)

Hanqiao Xu, Takashi Kurohara, Nobumichi Ohoka, Genichiro Tsuji, Takao Inoue, Mikihiko Naito & Yosuke Demizu. (2023) Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands. Bioorganic & Medicinal Chemistry, pages 117293.
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Kenneth K. W. To, Enming Xing, Ross C. Larue & Pui-Kai Li. (2023) BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications. Molecules 28:7, pages 3043.
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Jaeyoung Moon, Ichiwa Kitty, Kusuma Renata, Sisi Qin, Fei Zhao & Wootae Kim. (2023) DNA Damage and Its Role in Cancer Therapeutics. International Journal of Molecular Sciences 24:5, pages 4741.
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Ellen K. Crummy, Elizabeth A. Caine, Dareen Mikheil, Cesear Corona, Kristin M. Riching, Chris Hosfield & Marjeta Urh. 2023. Targeted Protein Degradation. Targeted Protein Degradation 81 113 .
Eros Di Giorgio, Roberta Benetti, Emanuela Kerschbamer, Luigi Xodo & Claudio Brancolini. 2023. 97 148 .
Abdelrahman K. A. A. Salama, Marija V. Trkulja, Emilio Casanova & Iris Z. Uras. (2022) Targeted Protein Degradation: Clinical Advances in the Field of Oncology. International Journal of Molecular Sciences 23:23, pages 15440.
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Irene Preet Bhela, Alice Ranza, Federica Carolina Balestrero, Marta Serafini, Silvio Aprile, Rita Maria Concetta Di Martino, Fabrizio Condorelli & Tracey Pirali. (2022) A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs. Journal of Medicinal Chemistry 65:22, pages 15282-15299.
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Wei Liu, Hairui Jia, Minghao Guan, Minxuan Cui, Zhuxuan Lan, Youyou He, Zhongjie Guo, Ru Jiang, Guoqiang Dong & Shengzheng Wang. (2022) Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorganic Chemistry 118, pages 105486.
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