Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

Ibrahim H. Eissaa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

https://orcid.org/0000-0002-6955-2263

Radwan El-Haggarb Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt;c Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, FranceCorrespondence[email protected]

Mohammed A. Dahaba Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Marwa F. Ahmedb Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt;d Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia

Hazem A. Mahdya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

https://orcid.org/0000-0002-6620-241X

Reem I. Alsantalid Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia

Alaa Elwana Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]

Nicolas Masurierc Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, FranceCorrespondence[email protected]

https://orcid.org/0000-0001-9169-8149

Samar S. Fatahalae Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

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Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

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Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

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