Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
Submit an article Journal homepage
2,881
Views
29
CrossRef citations to date
0
Altmetric
Research Papers

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

Mohammed S. Taghoura Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
,
Hazem Elkadya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
,
Wagdy M. Eldehnab Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt;c School of Biotechnology, Badr University in Cairo, Badr City, Cairo, EgyptView further author information
,
Nehal M. El-Deebd Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptView further author information
,
Ahmed M. Kenawye Nucleic Acids Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptView further author information
,
Eslam B. Elkaeedf Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaView further author information
,
Aisha A. Alsfoukg Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0003-4497-5013View further author information
ORCID Icon,
Mohamed S. Alesawya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
,
Ahmed M. Metwalyd Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt;h Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
View further author information
&
Ibrahim. H. Eissaa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6955-2263View further author information
ORCID Icon show all
Pages 1903-1917 | Received 18 Mar 2022, Accepted 29 May 2022, Published online: 08 Jul 2022

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Mai H. ElNaggar, Abdullah A. Elgazar, Ghada Gamal, Shimaa M. Hamed, Zainab M. Elsayed, Mohamed K. El-Ashrey, Amira Abood, Mahmoud A. El Hassab, Ahmed M. Soliman, Ramadan A. El-Domany, Farid A. Badria, Claudiu T. Supuran & Wagdy M. Eldehna. (2023) Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Moataz A. Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F. Khaleel, Abdelrahman I. Zain-Alabdeen, Zainab M. Elsayed, Eslam B. Elkaeed, Rofaida Salem, Claudiu T. Supuran, Wagdy M. Eldehna & Haytham O. Tawfik. (2023) Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Mohammed S. Taghour, Hazem Elkady, Wagdy M. Eldehna, Nehal El-Deeb, Ahmed M. Kenawy, Abeer E Abd El-Wahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies. Journal of Biomolecular Structure and Dynamics 41:21, pages 11535-11550.
Read now
Vinodkumar P. Sajjan, Lakkappa B. Anigol, Prabhuodeyara M. Gurubasavaraj, Dhanashree Patil, Parutagouda Shankaragouda Patil, Neelamma B. Gummagol, Ching Kheng Quah, Qin Ai Wong & Ismail Celik. (2023) New2-((2-(2,4-dinitrophenyl)hydrazineeylidene) derivatives: design, synthesis, in silico, and in vitro anticancer studies. Journal of Biomolecular Structure and Dynamics 41:21, pages 11681-11699.
Read now
Mohammed A. Dahab, Hazem A. Mahdy, Hazem Elkady, Mohammed S. Taghour, Alaa Elwan, Mohamed A. Elkady, Elsayed G. E. Elsakka, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-20.
Read now
Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-23.
Read now
Mehmet Gümüş, İrfan Koca, Yusuf Sert, Ali Dişli, Ezgi Nurdan Yenilmez Tunoğlu, Lütfi Tutar & Yusuf Tutar. (2023) Triad pyrazole–thiazole–coumarin heterocyclic core effectively inhibit HSP and drive cancer cells to apoptosis. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
Read now
Tarfah Al-Warhi, Mostafa M. Elbadawi, Alessandro Bonardi, Alessio Nocentini, Ahmed A. Al-Karmalawy, Nada Aljaeed, Ohoud J. Alotaibi, Hatem A. Abdel-Aziz, Claudiu T. Supuran & Wagdy M. Eldehna. (2022) Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2635-2643.
Read now
Esraa A. Abdelsalam, Amer Ali Abd El-Hafeez, Wagdy M. Eldehna, Mahmoud A. El Hassab, Hala Mohamed M. Marzouk, Mahmoud M. Elaasser, Nageh A. Abou Taleb, Kamilia M. Amin, Hatem A. Abdel-Aziz, Pradipta Ghosh & Sherif F. Hammad. (2022) Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2265-2282.
Read now

Articles from other publishers (19)

Tarfah Al-Warhi, Hadia Almahli, Raed M. Maklad, Zainab M. Elsayed, Mahmoud A. El Hassab, Ohoud J. Alotaibi, Nada Aljaeed, Rezk R. Ayyad, Hazem A. Ghabour, Wagdy M. Eldehna & Mohamed K. El-Ashrey. (2023) 1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights. Molecules 28:7, pages 3203.
Crossref
Anas Ramadan Kotb, Abdallah E. Abdallah, Hazem Elkady, Ibrahim H. Eissa, Mohammed S. Taghour, Dina Abed Bakhotmah, Tamer M. Abdelghany & Mohamed Ayman El-Zahabi. (2023) Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents . RSC Advances 13:16, pages 10488-10502.
Crossref
Ibrahim H. Eissa, Reda G. Yousef, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mohamed S. Alesawy, Hazem Elkady & Ahmed M. Metwaly. (2023) Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach. PLOS ONE 18:3, pages e0282586.
Crossref
Manasa A. Doddagaddavalli, Veerendra Kumar A. Kalalbandi & Jaldappagari Seetharamappa. (2023) Synthesis, characterization, crystallographic, binding, in silico and antidiabetic studies of novel 2,4-thiazolidinedione-phenothiazine molecular hybrids. Journal of Molecular Structure 1276, pages 134625.
Crossref
Cláudia Camacho, Dina Maciel, Helena Tomás & João Rodrigues. (2023) Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Study. Pharmaceutics 15:2, pages 689.
Crossref
Ahmed A. Al-Karmalawy, Mohamed S. Nafie, Moataz A. Shaldam, Ayman Abo Elmaaty, Samar A. Antar, Anwar A. El-Hamaky, Mohamed A. Saleh, Ahmed Elkamhawy & Haytham O. Tawfik. (2022) Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. Journal of Medicinal Chemistry 66:1, pages 777-792.
Crossref
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Bshra A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Eslam B. Elkaeed & Ahmed M. Metwaly. (2023) A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study. Life 13:1, pages 191.
Crossref
Omeed M. Hassan, Ammar A. Razzak Mahmood, Ali H. Hamzah & Lubna H. Tahtamouni. (2022) Design, Synthesis, and Molecular Docking Studies of 5‐Bromoindole‐2‐Carboxylic Acid Hydrazone Derivatives: In Vitro Anticancer and VEGFR‐2 Inhibitory Effects. ChemistrySelect 7:46.
Crossref
Mohamed A. Abdelrahman, Hadia Almahli, Tarfah Al-Warhi, Taghreed A. Majrashi, Marwa M. Abdel-Aziz, Wagdy M. Eldehna & Mohamed A. Said. (2022) Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis. Molecules 27:24, pages 8807.
Crossref
Eman S. Nossier, Rania A. Alasfoury, Mohamed Hagras, May El-Manawaty, Sara M. Sayed, Ibrahim M. Ibrahim, Hazem Elkady, Ibrahim H. Eissa & Heba S.A. Elzahabi. (2022) Modified pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation. Journal of Molecular Structure 1270, pages 133971.
Crossref
Anas Ramadan Kotb, Dina A. Bakhotmah, Abdallah E. Abdallah, Hazem Elkady, Mohammed S. Taghour, Ibrahim. H. Eissa & Mohamed Ayman El-Zahabi. (2022) Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents. RSC Advances 12:52, pages 33525-33539.
Crossref
Aysha Gaur, Mudasir Nabi Peerzada, Nashrah Sharif Khan, Imran Ali & Amir Azam. (2022) Synthesis and Anticancer Evaluation of Novel Indole Based Arylsulfonylhydrazides against Human Breast Cancer Cells. ACS Omega 7:46, pages 42036-42043.
Crossref
Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Ibraheem M. M. Gobaara, Hanan A. Al-ghulikah, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2022) (E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth Factor Receptor-2: Synthesis, Computational, and Anticancer Studies. Molecules 27:22, pages 7719.
Crossref
Moumen S. Kamel, Moustafa O. Aboelez, Mohamed R. Elnagar, Elders Kh. Shokr, Heba Mohammed Refat M. Selim, Hossam Eldin Abdel‐Ghany, Ali M. Drar, Amany Belal, Mohamed A. El Hamd & Mahmoud Abd El Aleem Ali Ali El‐Remaily. (2022) Green Synthesis Design, Spectroscopic Characterizations, and Biological Activities of Novel Pyrrole Derivatives: An Application to Evaluate Their Toxic Effect on Cotton Aphids . ChemistrySelect 7:40.
Crossref
Tarfah Al-Warhi, Al-Aliaa Sallam, Loah Hemeda, Mahmoud El Hassab, Nada Aljaeed, Ohoud Alotaibi, Ahmed Doghish, Mina Noshy, Wagdy Eldehna & Mona Ibrahim. (2022) Identification of Novel Cyanopyridones and Pyrido[2,3-d]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies. Pharmaceuticals 15:10, pages 1262.
Crossref
Harsh Kumar, Navidha Aggarwal, Minakshi Gupta Marwaha, Aakash Deep, Hitesh Chopra, Mohammed M. Matin, Arpita Roy, Talha Bin Emran, Yugal Kishore Mohanta, Ramzan Ahmed, Tapan Kumar Mohanta, Muthupandian Saravanan, Rakesh Kumar Marwaha & Ahmed Al-Harrasi. (2022) Thiazolidin-2,4-Dione Scaffold: An Insight into Recent Advances as Antimicrobial, Antioxidant, and Hypoglycemic Agents. Molecules 27:19, pages 6763.
Crossref
Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2022) New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies. Molecules 27:18, pages 5859.
Crossref
Alaa Elwan, Abdallah E. Abdallah, Hazem A. Mahdy, Mohammed A. Dahab, Mohammed S. Taghour, Eslam B. Elkaeed, Ahmed B. M. Mehany, Ahmed Nabeeh, Mohammed Adel, Aisha A. Alsfouk, Hazem Elkady & Ibrahim H. Eissa. (2022) Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation. Molecules 27:15, pages 5047.
Crossref
Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Ibraheem M. M. Gobaara, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2022) The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches. Processes 10:7, pages 1391.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.