Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

Asmaa A. Mandoura Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt

Ibrahim F. Nassarb Faculty of Specific Education, Ain Shams University (ASU), Cairo, Egypt

https://orcid.org/0000-0002-8123-2238

Mohammed T. Abdel Aalc Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Mahmoud A. E. Shahinc Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Wael A. El-Sayedd Chemistry Department, College of Science, Qassim University, Qassim, Saudi Arabia;e Photochemistry Department, National Research Centre, Cairo, Egypt

https://orcid.org/0000-0002-8232-1830

Maghawry Hegazyf Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Amr Mohamed Yehiaf Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Ahmed Ismailf Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Mohamed Hagrasg Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Eslam B. Elkaeedh Department of Pharmaceutical Science, College of Pharmacy, Al Maarefa University, Riyadh, Saudi Arabia

Hanan M. Refaata Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt

Nasser S. M. Ismaila Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-5119-9318

show all

Citations (5)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong & Zhiyong Yang. (2023) Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 84-99.
Read now

Articles from other publishers (4)

Meenakshi Verma, Laxmikant Trivedi & Prema G Vasudev. (2023) Interaction Patterns of Pyrazolopyrimidines with Receptor Proteins. Journal of Chemical Information and Modeling 63:8, pages 2331-2344.
Crossref

Sherif S. Abdel Mageed, Ahmed S. Doghish, Ahmed Ismail, Ahmed A. El-Husseiny, Sylvia F. Fawzi, Abdulla M.A. Mahmoud & Hesham A. El-Mahdy. (2023) The role of miRNAs in insulin resistance and diabetic macrovascular complications – A review. International Journal of Biological Macromolecules 230, pages 123189.
Crossref

PRIYANKA SOLANKI, NISARG RANA, PRAKASH C. JHA & ANU MANHAS. (2023) A comprehensive analysis of the role of molecular docking in the development of anticancer agents against the cell cycle CDK enzyme. BIOCELL 47:4, pages 707-729.
Crossref

Ahmed S. Doghish, Ahmed Ismail, Mahmoud A. Elrebehy, Abdullah M.M. Elbadry, Hend H. Mahmoud, Salma M. Farouk, Ghada A. Abu Serea, Rahma Ali A. Elghany, Kholoud K. El-Halwany, Abdulrahman Omar Alsawah, Hla I. Dewidar & Hesham A. El-Mahdy. (2022) A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay. Pathology - Research and Practice 237, pages 154053.
Crossref

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

Articles from other publishers (4)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

Citations (5)

Read on this site (1)

Articles from other publishers (4)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date