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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Brief Report

Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations

Giulio Polia Department of Pharmacy, University of Pisa, Pisa, ItalyORCID Iconhttps://orcid.org/0000-0002-8061-5632View further author information
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Ivana Barravecchiaa Department of Pharmacy, University of Pisa, Pisa, Italy;b Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, ItalyView further author information
,
Gian Carlo Demontisa Department of Pharmacy, University of Pisa, Pisa, ItalyORCID Iconhttps://orcid.org/0000-0001-7641-0426View further author information
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Andrea Sodic Department of Neurosciences, Psychology, Drug Research and Child Health Eye Clinic, University of Florence, AOU Careggi, Florence, ItalyView further author information
,
Alessandro Sabad Department of Surgical Pathology, Molecular Medicine and of the Critical Area, University of Pisa, Pisa, ItalyORCID Iconhttps://orcid.org/0000-0003-0611-5549View further author information
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Stanislao Rizzoe Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;f Catholic University Sacro Cuore, Rome, Italy;g Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Pisa, ItalyORCID Iconhttps://orcid.org/0000-0001-6302-063XView further author information
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Marco Macchiaa Department of Pharmacy, University of Pisa, Pisa, ItalyView further author information
&
Tiziano Tuccinardia Department of Pharmacy, University of Pisa, Pisa, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6205-4069View further author information
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Pages 1765-1772 | Received 05 May 2022, Accepted 10 Jun 2022, Published online: 21 Jun 2022

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Huayin Bao, Wei Wang, Haibo Sun & Jianzhong Chen. (2023) Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Giulio Poli, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia & Tiziano Tuccinardi. (2023) An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Articles from other publishers (2)

Biancamaria Longoni & Gian Carlo Demontis. (2023) Polyunsaturated Lipids in the Light-Exposed and Prooxidant Retinal Environment. Antioxidants 12:3, pages 617.
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N. Bielopolski, E. Heyman, H. Bassan, B. BenZeev, M. Tzadok, M. Ginsberg, L. Blumkin, Y. Michaeli, R. Sokol, N. Yosha-Orpaz, R. Hady-Cohen, E. Banne, D. Lev, T. Lerman-Sagie, S. Wald-Altman & A. Nissenkorn. (2022) “Virtual patch clamp analysis” for predicting the functional significance of pathogenic variants in sodium channels. Epilepsy Research 186, pages 107002.
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