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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Papers

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

Amany Belala Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt;b Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi ArabiaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-1045-0163View further author information
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Nagwa M. Abdel Gawadc Medicinal Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, EgyptCorrespondence[email protected]
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Ahmed B. M. Mehanyd Department of Zoology, Faculty of Science, Al-Azhar University, Nasr City, EgyptView further author information
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Mohammed A. S. Abourehabe Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia;f Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia, EgyptView further author information
,
Hazem Elkadyg Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Ahmed A. Al‐Karmalawyh Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University‐ Egypt, New Damietta, EgyptORCID Iconhttps://orcid.org/0000-0002-8173-6073View further author information
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Ahmed S. Ismaela Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptCorrespondence[email protected] [email protected]
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Pages 1884-1902 | Received 20 Apr 2022, Accepted 26 Jun 2022, Published online: 08 Jul 2022

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Tarfah Al-Warhi, Ahmed A. Al-Karmalawy, Ayman Abo Elmaaty, Maha A. Alshubramy, Marwa Abdel-Motaal, Taghreed A. Majrashi, Medhat Asem, Ahmed Nabil, Wagdy M. Eldehna & Marwa Sharaky. (2023) Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 176-191.
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Mohammed S. Taghour, Hazem Elkady, Wagdy M. Eldehna, Nehal El-Deeb, Ahmed M. Kenawy, Abeer E Abd El-Wahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies. Journal of Biomolecular Structure and Dynamics 41:21, pages 11535-11550.
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Vinodkumar P. Sajjan, Lakkappa B. Anigol, Prabhuodeyara M. Gurubasavaraj, Dhanashree Patil, Parutagouda Shankaragouda Patil, Neelamma B. Gummagol, Ching Kheng Quah, Qin Ai Wong & Ismail Celik. (2023) New2-((2-(2,4-dinitrophenyl)hydrazineeylidene) derivatives: design, synthesis, in silico, and in vitro anticancer studies. Journal of Biomolecular Structure and Dynamics 41:21, pages 11681-11699.
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Rohit Pal, Ghanshyam Teli, Sindhuja Sengupta, Lalmohan Maji & Gurubasavaraja Swamy Purawarga Matada. (2023) An outlook of docking analysis and structure-activity relationship of pyrimidine-based analogues as EGFR inhibitors against non-small cell lung cancer (NSCLC). Journal of Biomolecular Structure and Dynamics 0:0, pages 1-17.
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Mohamed H. Saad, Tarek F. El-Moselhy, Nabaweya S, El-Din, Ahmed B. M. Mehany, Amany Belal, Mohammed A. S. Abourehab, Haytham O. Tawfik & Mervat H. El-Hamamsy. (2022) Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2489-2511.
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