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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Papers

Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation

Mohammed S. Taghoura Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Hazem A. Mahdya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-6620-241XView further author information
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Maher H. Gomaab Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Ahmed Aglanb Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Mahmoud Gomaa Eldeibb Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Alaa Elwana Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Mohammed A. Dahaba Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Eslam B. Elkaeedc Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
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Aisha A. Alsfoukd Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0003-4497-5013View further author information
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Mohamed M. Khalifaa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-8146-993XView further author information
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Ibrahim H. Eissaa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6955-2263View further author information
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Hazem Elkadya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
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Pages 2063-2077 | Received 07 May 2022, Accepted 13 Jul 2022, Published online: 25 Jul 2022

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Mohammed S. Taghour, Hazem Elkady, Wagdy M. Eldehna, Nehal El-Deeb, Ahmed M. Kenawy, Abeer E Abd El-Wahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies. Journal of Biomolecular Structure and Dynamics 41:21, pages 11535-11550.
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Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-23.
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Mohamed Ayman El-Zahabi, Hazem Elkady, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa & Khaled. El-Adl. (2023) Design, synthesis, anticancer evaluation, in silico docking and ADMET analysis of novel indole-based thalidomide analogs as promising immunomodulatory agents. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-18.
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Articles from other publishers (6)

Ibrahim H. Eissa, Reda G. Yousef, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mohamed S. Alesawy, Hazem Elkady & Ahmed M. Metwaly. (2023) Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach. PLOS ONE 18:3, pages e0282586.
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Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Bshra A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Eslam B. Elkaeed & Ahmed M. Metwaly. (2023) A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study. Life 13:1, pages 191.
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Eman S. Nossier, Rania A. Alasfoury, Mohamed Hagras, May El-Manawaty, Sara M. Sayed, Ibrahim M. Ibrahim, Hazem Elkady, Ibrahim H. Eissa & Heba S.A. Elzahabi. (2022) Modified pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation. Journal of Molecular Structure 1270, pages 133971.
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Anas Ramadan Kotb, Dina A. Bakhotmah, Abdallah E. Abdallah, Hazem Elkady, Mohammed S. Taghour, Ibrahim. H. Eissa & Mohamed Ayman El-Zahabi. (2022) Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents. RSC Advances 12:52, pages 33525-33539.
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Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2022) New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies. Molecules 27:18, pages 5859.
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Alaa Elwan, Abdallah E. Abdallah, Hazem A. Mahdy, Mohammed A. Dahab, Mohammed S. Taghour, Eslam B. Elkaeed, Ahmed B. M. Mehany, Ahmed Nabeeh, Mohammed Adel, Aisha A. Alsfouk, Hazem Elkady & Ibrahim H. Eissa. (2022) Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation. Molecules 27:15, pages 5047.
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