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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Papers

Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

Jerneja Kladnika Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, SloveniaView further author information
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Ana Dolinara Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, SloveniaView further author information
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Jakob Kljuna Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, SloveniaView further author information
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David Pereab Infectious Diseases Department, Vall d’Hebron Research Institute (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, SpainView further author information
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Judith Grau-Expósitob Infectious Diseases Department, Vall d’Hebron Research Institute (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, SpainView further author information
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Meritxell Genescàb Infectious Diseases Department, Vall d’Hebron Research Institute (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, SpainView further author information
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Marko Novineca Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, SloveniaView further author information
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Maria J. Buzonb Infectious Diseases Department, Vall d’Hebron Research Institute (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, SpainCorrespondence[email protected]
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Iztok Turela Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, SloveniaCorrespondence[email protected]
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Pages 2158-2168 | Received 21 Jun 2022, Accepted 27 Jul 2022, Published online: 09 Aug 2022

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Jie Dong, Mihayl Varbanov, Stéphanie Philippot, Fanny Vreken, Wen-bin Zeng & Vincent Blay. (2023) Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddings. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 24-35.
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Articles from other publishers (5)

Ripul Mehrotra, Satyendra N. Shukla & Pratiksha Gaur. (2023) Metallo-antiviral aspirants: Answer to the upcoming virus outbreak. European Journal of Medicinal Chemistry Reports 8, pages 100104.
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Chezhiyan Sumithaa & Mani Ganeshpandian. (2023) Half-Sandwich Ruthenium Arene Complexes Bearing Clinically Approved Drugs as Ligands: The Importance of Metal–Drug Synergism in Metallodrug Design. Molecular Pharmaceutics 20:3, pages 1453-1479.
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Tomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Iztok Turel & Robert Frangež. (2023) Novel Organoruthenium(II) Complex C1 Selectively Inhibits Butyrylcholinesterase without Side Effects on Neuromuscular Transmission. International Journal of Molecular Sciences 24:3, pages 2681.
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Cameron Lee Shetler, Juliana C. Ferreira, Thyago H. S. Cardoso, Edson M.A. Silva, Nitin K. Saksena & Wael M. Rabeh. (2022) Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2. Biochemical Journal 479:20, pages 2175-2193.
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Marko Novinec, Primož Bembič, Milica Janković, Marija Kisilak, Jakob Kljun & Iztok Turel. (2022) Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S. International Journal of Molecular Sciences 23:16, pages 8993.
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