Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR^WT and EGFR^T790M

Ahmed A. Gabera Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information

Mohamed Sobhya Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information

Abdallah Turkya Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information

Hanan Gaber Abdulwahabb Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptView further author information

Ahmed A. Al-Karmalawyc Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt

https://orcid.org/0000-0002-8173-6073 View further author information

Mostafa. A. Elhendawyd Department of Chemistry and Biochemistry, University of Mississippi, MS, USA;e Department of Agriculture Chemistry, Faculty of Agriculture, Damietta University, Damietta, EgyptView further author information

Mohamed. M. Radwanf National Center for Natural Products Research, University of Mississippi, University, MS, USA;g Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptView further author information

Eslam B. Elkaeedh Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaView further author information

Ibrahim M. Ibrahimi Biophysics Department, Faculty of Science, Cairo University, Cairo, EgyptView further author information

Heba S. A. Elzahabib Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptView further author information

Ibrahim H. Eissaj Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-6955-2263 View further author information

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Sushanta Halder, Soumi Basu, Shobhit P. Lall, Apar K. Ganti, Surinder K. Batra & Parthasarathy Seshacharyulu. (2023) Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?. Expert Opinion on Therapeutic Targets 27:4-5, pages 305-324.
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Asmaa Kamal Mourad, Fatehia K. Mohammed, Abd El‐Naby Ibrahim Essawy, Ahmed Yousef Soliman & Samar Magdy Sayed. (2023) Pyrazolo[3,4‐ d ]pyrimidine‐based scaffolds as antibacterial agents: Synthetic strategies, reactions, and in vitro biological evaluation . Journal of Heterocyclic Chemistry 60:7, pages 1150-1164.
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Shengbang Wang, Xiu Zhang, Hao Lei, Liumei Song, Yingjian Huang, Tong Kang, Mengdi Zhang, Ning Wang, Pengju Yang, Shuo Feng, Jingping Wang, Ruimin Bai, Nan Wang, Wei Wang & Yan Zheng. (2023) Proline‐rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway. Molecular Carcinogenesis 62:5, pages 613-627.
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Mengmiao Zhao, Kan Yang, Xinyue Zhu, Tian Gao, Wei Yu, Han Liu, Zhihao You, Zhenming Liu, Xiaoqiang Qiao & Yali Song. (2023) Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. European Journal of Medicinal Chemistry 252, pages 115303.
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Naglaa M. Ahmed, Ahmed H. Lotfallah, Mohamed S. Gaballah, Samir M. Awad & Moustafa K. Soltan. (2023) Novel 2-Thiouracil-5-Sulfonamide Derivatives: Design, Synthesis, Molecular Docking, and Biological Evaluation as Antioxidants with 15-LOX Inhibition. Molecules 28:4, pages 1925.
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Afaf Y. Khormi, Thoraya. A. Farghaly, Abrar Bayazeed, Youssef O. Al-Ghamdi, Hanan Gaber Abdulwahab & Mohamed R. Shaaban. (2022) Novel thiazole derivatives incorporating phenyl sulphonyl moiety as potent BRAFV600E kinase inhibitors targeting melanoma. RSC Advances 12:42, pages 27355-27369.
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Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR^WT and EGFR^T790M

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Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M

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Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR^WT and EGFR^T790M