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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks

John N. Philoppesa Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information
,
Mohamed A. Abdelgawadb Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaCorrespondence[email protected]
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,
Mohammed A. S. Abourehabc Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaCorrespondence[email protected]
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,
Mohamed Sebakd Microbiology and Immunology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information
,
Mostafa A. Darwishe Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, EgyptView further author information
&
Phoebe F. Lamiea Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptCorrespondence[email protected] [email protected]
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Pages 246-266 | Received 19 Jul 2022, Accepted 02 Nov 2022, Published online: 01 Dec 2022

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Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity & Aly A. Hazzaa. (2024) Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof. Journal of Enzyme Inhibition and Medicinal Chemistry 39:1.
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Fengmei Zhang, Guonian Zhu, Yangqian Li, Yawen Qi, Zhoufeng Wang & Weimin Li. (2023) Dual-Target Inhibitors Based on COX-2: A Review from Medicinal Chemistry Perspectives. Future Medicinal Chemistry 15:23, pages 2209-2233.
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Articles from other publishers (4)

Abhishek Kar, Gopal Rana, Rajkamal Sahoo, Sourav Ghosh & Umasish Jana. (2024) Design and Synthesis of Indazole–Indole Hybrid via tert -Butyl Nitrite Mediated Cascade Diazotization/Isomerization/Cyclization . The Journal of Organic Chemistry.
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Prayaga Rajappan Krishnendu, Sonu Benny, Sunil Kumar, Jayalakshmi Jayan, Vaishnav Bhaskar, Leena.K. Pappachen, T P Aneesh, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Orazio Nicolotti, Subin Mary Zachariah & Bijo Mathew. (2024) A structure-based approach to explore novel COX-2 inhibitors using pharmacophore modelling, 3D-QSAR analysis, virtual screening and dynamics simulation study. Journal of Molecular Structure 1295, pages 136634.
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Pei-Ning Yang, Wan-Ling Chen, Jun-Wei Lee, Chih-Hsin Lin, Yi-Ru Chen, Chung-Yin Lin, Wenwei Lin, Ching-Fa Yao, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen & Guey-Jen Lee-Chen. (2023) Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity. Aging 15:16, pages 8061-8089.
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Mithun Rudrapal, Wafa Ali Eltayeb, Gourav Rakshit, Amr Ahmed El-Arabey, Johra Khan, Sahar M. Aldosari, Bader Alshehri & Mohnad Abdalla. (2023) Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies. Scientific Reports 13:1.
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