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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities

Mostafa M. M. El-Miligya Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4832-0719View further author information
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Marwa E. Abdelaziza Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptCorrespondence[email protected]
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Salwa M. Fahmya Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptView further author information
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Tamer M. Ibrahimb Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptView further author information
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Marwa M. Abu-Seriec Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt)View further author information
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Mona A. Mahrana Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptView further author information
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Aly A. Hazzaaa Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptView further author information
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Article: 2152810 | Received 25 Oct 2022, Accepted 24 Nov 2022, Published online: 11 Jan 2023

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Marwa E. Abdelaziz, Mostafa M. M. El-Miligy, Salwa M. Fahmy, Marwa M. Abu-Serie, Aly A. Hazzaa & Mona A. Mahran. (2024) Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis. Journal of Enzyme Inhibition and Medicinal Chemistry 39:1.
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Articles from other publishers (5)

Anushka Sharma, Rahul Dubey, Vikas Asati, Gurkaran Singh Baweja, Shankar Gupta & Vivek Asati. (2024) Assessment of structural and activity-related contributions of various PIM-1 kinase inhibitors in the treatment of leukemia and prostate cancer. Molecular Diversity.
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Li Chen, Wuyu Mao, Changyu Ren, Jinqi Li & Jifa Zhang. (2024) Comprehensive Insights that Targeting PIM for Cancer Therapy: Prospects and Obstacles. Journal of Medicinal Chemistry 67:1, pages 38-64.
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Vinod Kumar Gurjar, Vivek Shrivastava, Shweta Jain, Rakesh Chawla & Ankur Vaidya. 2024. Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy. Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy 255 321 .
Shrouk M. Shaban, Elsayed H. Eltamany, Ahmed T. A. Boraei, Mohamed S. Nafie & Emad M. Gad. (2023) Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega 8:49, pages 46922-46933.
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Vandana Nandakumar, Amsaveni Sundarasamy, Kaviyarasu Adhigaman, Sentamil Selvi Ramasamy, Manickam Paulpandi, Gothandam Kodiveri Muthukaliannan, Arul Narayanasamy & Suresh Thangaraj. (2023) Anti-proliferative activity of nitroquinolone fused acylhydrazones as non-small cell human lung cancer agents. RSC Medicinal Chemistry 14:7, pages 1331-1343.
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