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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity

Mai A. E. Mourada Medicinal Chemistry Department, Faculty of Pharmacy, Port-Said University, Port-Said, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9929-3741View further author information
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Ayman Abo Elmaatya Medicinal Chemistry Department, Faculty of Pharmacy, Port-Said University, Port-Said, EgyptView further author information
,
Islam Zakib Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port-Said University, Port-Said, EgyptView further author information
,
Ahmed A. E. Mouradc Pharmacology and Toxicology Department, Faculty of Pharmacy, Port-Said University, Port-Said, EgyptORCID Iconhttps://orcid.org/0000-0001-8823-8774View further author information
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Amal Hofnid Department of Pharmacology and Toxicology, Faculty of Pharmacy, South Valley University, Qena, EgyptView further author information
,
Ahmed E. Khodire Department of Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, EgyptView further author information
,
Esam M. Aboubakrd Department of Pharmacology and Toxicology, Faculty of Pharmacy, South Valley University, Qena, EgyptView further author information
,
Ahmed Elkamhawyf BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University—Seoul, Goyang, Republic of Korea;g Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
,
Eun Joo Rohh Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology (KIST), Seoul, Korea;i Division of Bio-Medical Science & Technology, University of Science and Technology, Daejeon, KoreaCorrespondence[email protected]
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Ahmed A. Al-Karmalawyj Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, EgyptORCID Iconhttps://orcid.org/0000-0002-8173-6073View further author information
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Article: 2205043 | Received 13 Mar 2023, Accepted 16 Apr 2023, Published online: 11 May 2023

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Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee & Ahmed A. Al-Karmalawy. (2023) Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Lamiaa Abellatef Ali Barakat, Ibrahim Mohy El-Deen, Manar Abdo El-Zend & Mohammed El-Behery. (2023) In Vitro Cytotoxic Investigation of Some Synthesized 1,6-Disubstituted-1-Azacoumarin Derivatives as Anticancer Agents. Future Medicinal Chemistry 15:24, pages 2289-2307.
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Ahmed A Gaber, Marwa Sharaky, Ayman Abo Elmaaty, Mohamed M Hammouda, Ahmed AE Mourad, Samy Y Elkhawaga, Mahmoud Mohamed Mokhtar, Amr S Abouzied, Mai AE Mourad & Ahmed A Al-Karmalawy. (2023) Design and Synthesis of Novel Pyrazolopyrimidine Candidates As Promising EGFR-T790M Inhibitors and Apoptosis Inducers. Future Medicinal Chemistry 15:19, pages 1773-1790.
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Articles from other publishers (5)

Ahmed A Gaber, Ayman Abo Elmaaty, Marwa Sharaky, Aliaa A. Mosa, Abdullah Yahya Abdullah Alzahrani, Saad Shaaban, Wagdy M. Eldehna & Ahmed A. Al-Karmalawy. (2024) Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction. Bioorganic Chemistry 145, pages 107223.
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Ahmed M. Fouda, R.A. El-Eisawy, Mohammed A.A. El-Nassag, Hany M. Mohamed, Ashraf H.F. Fekry, Heba K.A. El-Mawgoud, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ahmed A. Elhenawy, Ahmed Mora & Ahmed M. El-Agrody. (2024) Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and molecular docking studies. Journal of Molecular Structure 1295, pages 136518.
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Eslam M. Abbass, Ahmed A. Al-Karmalawy, Marwa Sharaky, Muhammad Khattab, Abdullah Yahya Abdullah Alzahrani & Aya I. Hassaballah. (2024) Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer. Bioorganic Chemistry 142, pages 106936.
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Ahmed I. Abd El Maksoud, Ahmed A. Al‐Karmalawy, Dalia ElEbeedy, Aml Ghanem, Yasmin Rasheed, Ibrahim A. Ibrahim, Reem A. Elghaish, Amany Belal, Mona A. Raslan & Rehab F. Taher. (2023) Symbiotic Antidiabetic Effect of Lactobacillus casei and the Bioactive Extract of Cleome droserifolia ( Forssk.) Del. on Mice with Type 2 Diabetes Induced by Alloxan . Chemistry & Biodiversity 21:1.
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Hossam Nada, Anam Rana Gul, Ahmed Elkamhawy, Sungdo Kim, Minkyoung Kim, Yongseok Choi, Tae Jung Park & Kyeong Lee. (2023) Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer─Design, Synthesis, and In Vitro Evaluation. ACS Omega 8:35, pages 31784-31800.
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