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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Article

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors

Eman A. Sobha Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, EgyptCorrespondence[email protected]
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Mohammed A. Dahabb Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2016-0728View further author information
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Eslam B. Elkaeedc Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaView further author information
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Aisha A. Alsfoukd Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaView further author information
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Ibrahim M. Ibrahime Biophysics Department, Faculty of Science, Cairo University, Cairo, EgyptView further author information
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Ahmed M. Metwalyf Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt;g Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptORCID Iconhttps://orcid.org/0000-0001-8566-1980View further author information
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Ibrahim H. Eissab Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6955-2263View further author information
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Article: 2220579 | Received 18 Feb 2023, Accepted 29 May 2023, Published online: 08 Jun 2023

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Souad A El-Metwally, Hazem Elkady, Mohamed Hagras, Eslam B Elkaeed, Bshra A Alsfouk, Ahmed S Doghish, Ibrahim M Ibrahim, Mohammed S Taghour, Dalal Z Husein, Ahmed M Metwaly & Ibrahim H Eissa. (2023) Discovery of New VEGFR-2 Inhibitors and Apoptosis inducer-based thieno[2,3-d]pyrimidine. Future Medicinal Chemistry 15:22, pages 2065-2086.
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Articles from other publishers (5)

Wael A.A. Fadaly, Mohamed T.M. Nemr & Nesma M. Kahk. (2024) Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities. Bioorganic Chemistry 147, pages 107403.
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Muhammad Tukur Ibrahim, Kamal Tabti, Safiya Abdulsalam, Abdulsalam Salisu Tahir, Abdulhamid Mahmoud & Aisha Muhammad Danmallam. (2024) Discovery of new 2,4-diaminopyrimidines derivatives as EGFRT790M kinase inhibitors: a structure-based approach with DFT calculation, drug-likeness, ADME-toxicity properties evaluation and MD simulation. Journal of Umm Al-Qura University for Applied Sciences.
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Ibrahim H. Eissa, Reda G.Yousef, Hazem Elkady, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mostafa A. Asmaey & Ahmed M. Metwaly. (2023) A new anticancer derivative of the natural alkaloid, theobromine, as an EGFR inhibitor and apoptosis inducer. Theoretical Chemistry Accounts 143:1.
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Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Dalal Z. Husein, Ibrahim M. Ibrahim, Bshra A. Alsfouk, Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed M. Kenawy, Nehal El-Deeb & Ahmed M. Metwaly. (2023) New theobromine derivative as apoptotic anti-triple-negative breast cancer targeting EGFR protein: CADD story. Journal of Molecular Structure 1294, pages 136336.
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Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah & Mona S. El-Zoghbi. (2023) Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies. Pharmaceuticals 16:9, pages 1303.
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