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Original Article

Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial

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Pages 3647-3654 | Received 13 Dec 2017, Accepted 24 Apr 2018, Published online: 09 May 2018

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Read on this site (1)

Laura Cuzzolin, Flamina Bardanzellu & Vassilios Fanos. (2018) The dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution?. Expert Opinion on Drug Metabolism & Toxicology 14:8, pages 855-868.
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Articles from other publishers (27)

Jing-jing Pan, Yang Yang, Shu-dong Cui, Xiao-qing Chen & Xiao-guang Zhou. (2023) Effectiveness and safety of rectal dexibuprofen versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants with gestational age<34 weeks: A pilot study. International Journal of Immunopathology and Pharmacology 37, pages 039463202311529.
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Agata Stróżyk, Themistoklis Paraskevas, Olga Romantsik, Maria Grazia Calevo, Rita Banzi, David Ley & Matteo Bruschettini. (2023) Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews. Cochrane Database of Systematic Reviews 2023:8.
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Souvik Mitra, Willem P de Boode, Dany E Weisz & Prakeshkumar S Shah. (2023) Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews. Cochrane Database of Systematic Reviews 2023:4.
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Abiola Olowoyeye, Onyinye Nnamdi-Nwosu, Maika Manalastas & Charles Okwundu. (2022) A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus. Pediatric Cardiology 44:4, pages 748-756.
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Ayman Saker, Aimann Surak, Susan Kimani, Andrea De La Hoz, Michael R. Miller, Renjini Lalitha & Soume Bhattacharya. (2023) Combination therapy for patent ductus arteriosus in preterm infants: Echocardiographic changes and clinical use. Progress in Pediatric Cardiology 68, pages 101611.
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Bonny Jasani, Souvik Mitra & Prakeshkumar S Shah. (2022) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2022:12.
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David J. McCulley, Erik A. Jensen, Jennifer M. S. Sucre, Sarah McKenna, Laura G. Sherlock, Evgenia Dobrinskikh & Clyde J. Wright. (2022) Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. American Journal of Physiology-Lung Cellular and Molecular Physiology 323:1, pages L1-L13.
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Dimitrios N. Katsaras, Georgios N. Katsaras, Vasiliki I. Chatziravdeli, Garyfalia N. Papavasileiou, Maria Touloupaki, Georgios Mitsiakos, Chrysoula Doxani, Ioannis Stefanidis & Efthimios Dardiotis. (2022) Comparative safety and efficacy of paracetamol versus non‐steroidal anti‐inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta‐analysis of randomized controlled trials. British Journal of Clinical Pharmacology 88:7, pages 3078-3100.
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Aoife Branagan, Caoimhe S. Costigan, Maria Stack, Cara Slagle & Eleanor J. Molloy. (2022) Management of Acute Kidney Injury in Extremely Low Birth Weight Infants. Frontiers in Pediatrics 10.
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Ramesh Vidavalur. (2022) Efficacy and Costs of Three Pharmacotherapies for Patent Ductus Arteriosus Closure in Premature Infants. Pediatric Drugs 24:2, pages 93-102.
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Xie Zi-Yun, Zhang Ruo-lin, Xia Yue-wei & Bo Tao. (2022) Efficacy and Safety of Oral Acetaminophen for Premature Infants With Patent Ductus Arteriosus: A Meta-Analysis. Frontiers in Pharmacology 12.
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Ufuk Cakir & Cuneyt Tayman. (2021) Qual Deve Ser o Tratamento de Primeira Linha para o Fechamento de Persistência de Canal Arterial Hemodinamicamente Significativo em Bebês Prematuros?. Arquivos Brasileiros de Cardiologia.
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Clyde J. Wright. (2021) Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?. The Journal of Pediatrics 235, pages 264-276.e1.
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Susan Kimani, Aimann Surak, Michael Miller & Soume Bhattacharya. (2021) Use of combination therapy with acetaminophen and ibuprofen for closure of the patent ductus arteriosus in preterm neonates. Paediatrics & Child Health 26:4, pages e177-e183.
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Maika Manalastas, Fatima Zaheer, Pamela Nicoski, Marc G. Weiss & Sachin Amin. (2021) Acetaminophen Therapy for Persistent Patent Ductus Arteriosus. NeoReviews 22:5, pages e320-e331.
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Ruben Vaidya, Alexander Knee, Yvonne Paris & Rachana Singh. (2020) Predictors of successful patent ductus arteriosus closure with acetaminophen in preterm infants. Journal of Perinatology 41:5, pages 998-1006.
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Robert Godin, Juan Carlos Rodriguez & Doron J. Kahn. (2021) Oral Versus Intravenous Medications for Treatment of Patent Ductus Arteriosus in Preterm Neonates: A Cost-Saving Initiative. The Journal of Pediatric Pharmacology and Therapeutics 26:3, pages 291-299.
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Emel Okulu, Omer Erdeve, Zehra Arslan, Nihal Demirel, Huseyin Kaya, Ismail Kursad Gokce, Sabahattin Ertugrul, Merih Cetinkaya, Gokhan Buyukkale, Ferda Ozlu, Huseyin Simsek, Yalcin Celik, Hilal Ozkan, Nilgun Köksal, Baris Akcan, Munevver Turkmen, Kiymet Celik, Didem Armangil, Ali Bulbul, Kadir Serafettin Tekgunduz, Mehmet Yekta Oncel, Funda Tuzun, Ebru Ergenekon, Hacer Ergin & Saadet Arsan. (2020) An Observational, Prospective, Multicenter, Registry-Based Cohort Study Comparing Conservative and Medical Management for Patent Ductus Arteriosus. Frontiers in Pediatrics 8.
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Nancy K. Hills & Ronald Clyman. (2020) Paracetamol (Acetaminophen) for Patent Ductus Arteriosus: Where Do We Stand?. The Journal of Pediatrics 222, pages 18-21.
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Tongyan Han, Huiqiang Liu, Hui Zhang, Ming Guo, Xuefeng Zhang, Yang Duan, Fuqiang Sun, Xinjian Liu, Xiang Zhang, Mingtao Zhang, Fang Liu, Lisha Bao, Min Xiao, Weili Liu, Rui Jiang, Jun Zheng, Xiuying Tian, Qi Gao, Wanxian Zhang, Wei Guo, Ling Li & Xiaomei Tong. (2020) Minimally Invasive Surfactant Administration for the Treatment of Neonatal Respiratory Distress Syndrome: A Multicenter Randomized Study in China. Frontiers in Pediatrics 8.
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Raymond Pranata, Emir Yonas, Rachel Vania & Radityo Prakoso. (2020) The efficacy and safety of oral paracetamol versus oral ibuprofen for patent ductus arteriosus closure in preterm neonates – A systematic review and meta-analysis. Indian Heart Journal 72:3, pages 151-159.
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Yingqi Xiao, Hui Liu, Rujun Hu, Qiang You, Min Zeng & Xiaolian Jiang. (2020) Efficacy and Safety of Paracetamol for Patent Ductus Arteriosus Closure in Preterm Infants: An Updated Systematic Review and Meta-Analysis. Frontiers in Pediatrics 7.
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K Dathe, J Frank, S Padberg, S Hultzsch, K Meixner, E Beck, R Meister & C Schaefer. (2019) Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third‐trimester paracetamol use: evaluation of the German Embryotox cohort. BJOG: An International Journal of Obstetrics & Gynaecology 126:13, pages 1560-1567.
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Katarina Dathe & Christof Schaefer. (2019) The Use of Medication in Pregnancy. Deutsches Ärzteblatt international.
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Jin A Lee. (2019) Practice for preterm patent ductus arteriosus; focusing on the hemodynamic significance and the impact on the neonatal outcomes. Korean Journal of Pediatrics 62:7, pages 245-251.
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Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C. Hassinger, Susan W. Aucott, Madoka Hayashi, Anne Marie Heuchan, William A. Carey, Matthew Derrick, Ilene Sue Wolf, Amy Kimball, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize & Ronald I. Clyman. (2019) Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320). Journal of Perinatology 39:5, pages 599-607.
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Birol Karabulut & Sebnem Paytoncu. (2019) Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants. Pediatric Drugs 21:2, pages 113-121.
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