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Review Articles

Metformin versus insulin for gestational diabetes: a systematic review and meta-analysis

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Pages 2741-2753 | Received 31 May 2019, Accepted 18 Sep 2019, Published online: 26 Sep 2019

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Lan Jiang, Chenlin Gao, Peijun Yan, Pan Chen, Chunxia Jiang, Yong Xu & Muhu Chen. (2022) Omega-3 fatty acids plus vitamin for women with gestational diabetes or prediabetes: a meta-analysis of randomized controlled studies. The Journal of Maternal-Fetal & Neonatal Medicine 35:16, pages 3135-3142.
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Yanlang He, Zhijie Huang, Changli Wei & Jianyong Chen. (2023) Case Report: Abruptio placentae and epileptic seizure after occurrence of perinatal hyperglycaemia in woman with gestational diabetes mellitus and hypertriglyceridemia-induced acute pancreatitis. Frontiers in Endocrinology 14.
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Papa Dasari, Bhagyashree Gundagurti & Kayathri Karthikeyan. (2022) Comparison of metformin and insulin therapy for the treatment of gestational diabetes mellitus—a randomised controlled trial. International Journal of Diabetes in Developing Countries 43:4, pages 523-528.
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Christine Newman, Louise Rabbitt, Adesuwa Ero & Fidelma P. Dunne. (2023) Focus on Metformin: Its Role and Safety in Pregnancy and Beyond. Drugs 83:11, pages 985-999.
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Giulia Tosti, Annarita Barberio, Linda Tartaglione, Alessandro Rizzi, Mauro Di Leo, Luca Viti, Angelo Sirico, Sara De Carolis, Alfredo Pontecorvi, Antonio Lanzone & Dario Pitocco. (2023) Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond. Frontiers in Endocrinology 14.
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Anita Semertzidou, Harriet Grout-Smith, Ilkka Kalliala, Akanksha Garg, Vasso Terzidou, Julian Marchesi, David MacIntyre, Phillip Bennett, Konstantinos Tsilidis & Maria Kyrgiou. (2023) Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature. BMC Medicine 21:1.
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Masoumeh Karami, Seyyed Hossein Mousavi, Mohammad Rafiee, Reza Heidari & Seyedeh Zahra Shahrokhi. (2023) Biochemical and molecular biomarkers: unraveling their role in gestational diabetes mellitus. Diabetology & Metabolic Syndrome 15:1.
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Bo Sheng, Juan Ni, Bin Lv, Guoguo Jiang, Xuemei Lin & Hao Li. (2023) Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials. Acta Diabetologica 60:5, pages 595-608.
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Ruixin Hu, Linhai Zou, Li Wang, Chunxue Xu, Mengmeng Qi, Zhihong Yang, Guohui Jiang & Lixia Ji. (2022) Probiotics alleviate maternal metabolic disorders and offspring-islet abnormalities in gestational diabetic mice. Journal of Functional Foods 99, pages 105300.
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Ruoyao Sun. (2022) The Harm and Prevention and Control of Gestational Diabetes Mellitus. Highlights in Science, Engineering and Technology 19, pages 106-111.
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Fang Li, Ligang Liu, Yang Hu, Carrie McAdam Marx & Wei Liu. (2022) Efficacy and safety of metformin compared to insulin in gestational diabetes: a systematic review and meta-analysis of Chinese randomized controlled trials. International Journal of Clinical Pharmacy 44:5, pages 1102-1113.
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Carolina Tocantins, Mariana S. Diniz, Luís F. Grilo & Susana P. Pereira. (2022) The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring. WIREs Mechanisms of Disease 14:4.
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Ioannis Ilias, Manfredi Rizzo & Lina Zabuliene. (2022) Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review. Medicina 58:3, pages 430.
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Eline G M van Hoorn, Peter R van Dijk, Jelmer R Prins, Helen L Lutgers, Klaas Hoogenberg, Jan Jaap H M Erwich & Adriaan Kooy. (2022) Pregnancy Outcomes: Effects of Metformin (POEM) study: a protocol for a long-term, multicentre, open-label, randomised controlled trial in gestational diabetes mellitus. BMJ Open 12:3, pages e056282.
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Ke He, Qing Guo, Jun Ge, Jingxin Li, Caixia Li & Zeng Jing. (2021) The efficacy and safety of metformin alone or as an add‐on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta‐analysis of 21 randomized controlled trials. Journal of Clinical Pharmacy and Therapeutics 47:2, pages 168-177.
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Kerstin M G Brand, Laura Saarelainen, Jaak Sonajalg, Emmanuelle Boutmy, Caroline Foch, Marja Vääräsmäki, Laure Morin-Papunen, Judith Schlachter, Katja M Hakkarainen & Pasi Korhonen. (2022) Metformin in pregnancy and risk of adverse long-term outcomes: a register-based cohort study. BMJ Open Diabetes Research & Care 10:1, pages e002363.
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Marit L. Bovbjerg. (2021) Current Resources for Evidence-Based Practice, November 2021. Journal of Obstetric, Gynecologic & Neonatal Nursing 50:6, pages 789-800.
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Hong Ouyang & Na Wu. (2021) Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis. Diabetes Therapy 12:10, pages 2715-2753.
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Catherine A Cluver, Richard Hiscock, Eric H Decloedt, David R Hall, Sonja Schell, Ben W Mol, Fiona Brownfoot, Tu’uhevaha J Kaitu’u-Lino, Susan P Walker & Stephen Tong. (2021) Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial. BMJ, pages n2103.
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Jane L. Tarry-Adkins, Susan E. Ozanne & Catherine E. Aiken. (2021) Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. Scientific Reports 11:1.
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Xian Wang, Wanting Liu, Huizhen Chen & Qiu Chen. (2021) Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Gynecologic and Obstetric Investigation 86:3, pages 218-230.
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Alfonso Mate, Antonio J. Blanca, Rocío Salsoso, Fernando Toledo, Pablo Stiefel, Luis Sobrevia & Carmen M. Vázquez. (2020) Response to Letter to the Editor by Briana and Malamitsi-Puchner: Effects of Pregnancy-induced Insulin Resistance on the Fetus and the Future Development of Metabolic Diseases in Adulthood . Current Vascular Pharmacology 18:4, pages 423-424.
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