Upstream versus downstream thrombin inhibition

Anouk J. W. GulpenDepartment of Biochemistry, Maastricht University, Maastricht, The Netherlands;Department of Internal Medicine, Maastricht University Medical Centre, Maastricht (MUMC), Maastricht, The NetherlandsCorrespondence[email protected]
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Arina J. Ten Cate-HoekDepartment of Biochemistry, Maastricht University, Maastricht, The Netherlands;Thrombosis Expertise Centre, Maastricht University Medical Centre, Maastricht (MUMC), Maastricht, The NetherlandsView further author information

Hugo Ten CateDepartment of Biochemistry, Maastricht University, Maastricht, The Netherlands;Department of Internal Medicine, Maastricht University Medical Centre, Maastricht (MUMC), Maastricht, The Netherlands;Thrombosis Expertise Centre, Maastricht University Medical Centre, Maastricht (MUMC), Maastricht, The NetherlandsView further author information

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Sophie C. Dólleman, Stijn M. Agten, Henri M.H. Spronk, Tilman M. Hackeng, Mettine H.A. Bos, Henri H. Versteeg, Anton Jan van Zonneveld & Hetty C. de Boer. (2022) Thrombin in complex with dabigatran can still interact with PAR‐1 via exosite‐I and instigate loss of vascular integrity. Journal of Thrombosis and Haemostasis 20:4, pages 996-1007.
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Charles G. Clark, Karen A. Rossi, James R. Corte, Tianan Fang, Joanne M. Smallheer, Indawati De Lucca, David S. Nirschl, Michael J. Orwat, Donald J.P. Pinto, Zilun Hu, Yufeng Wang, Wu Yang, Yoon Jeon, William R. Ewing, Joseph E. MyersJr.Jr., Steven Sheriff, Zhen Lou, Jeffrey M. Bozarth, Yiming Wu, Alan Rendina, Timothy Harper, Joanna Zheng, Baomin Xin, Qian Xiang, Joseph M. Luettgen, Dietmar A. Seiffert, Ruth R. Wexler & Patrick Y.S. Lam. (2019) Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Bioorganic & Medicinal Chemistry Letters 29:19, pages 126604.
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Alexander W. Koch, Nikolaus Schiering, Samu Melkko, Stefan Ewert, Janeen Salter, Yiming Zhang, Peter McCormack, Jianying Yu, Xueming Huang, Yu-Hsin Chiu, Zhiping Chen, Simone Schleeger, Geraldine Horny, Keith DiPetrillo, Lionel Muller, Andreas Hein, Frederic Villard, Meike Scharenberg, Paul Ramage, Ulrich Hassiepen, Serge Côté, Julie DeGagne, Carsten Krantz, Jörg Eder, Brian Stoll, Kenneth Kulmatycki, David L. Feldman, Peter Hoffmann, Craig T. Basson, Robert J. A. Frost & Yasser Khder. (2019) MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans. Blood 133:13, pages 1507-1516.
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Peter M. Fischer. (2017) Design of Small-Molecule Active-Site Inhibitors of the S1A Family Proteases as Procoagulant and Anticoagulant Drugs. Journal of Medicinal Chemistry 61:9, pages 3799-3822.
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Upstream versus downstream thrombin inhibition

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Upstream versus downstream thrombin inhibition

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