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Natural Product Research
Formerly Natural Product Letters
Volume 22, 2008 - Issue 13
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Original Articles

Hypoglycaemic activity of saponin fraction extracted from Momordica charantia in PEG/salt aqueous two-phase systems

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Pages 1112-1119 | Received 31 Jul 2007, Accepted 07 Dec 2007, Published online: 14 Oct 2008

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Read on this site (7)

Xiaoling Yu, Tongchun Su & Bing Liu. (2023) Two new triterpenoids preventing the hydrocortisone-induced injury in HMEC-1 cells from Momordica charantia L.. Natural Product Research 37:4, pages 663-668.
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Yifan Zhou & Baojun Xu. (2022) New insights into anti-diabetes effects and molecular mechanisms of dietary saponins. Critical Reviews in Food Science and Nutrition 0:0, pages 1-26.
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Sumit Mishra, Rakesh Sharma, Navdeep Gogna & Kavita Dorai. (2022) NMR-based metabolomic profiling of the differential concentration of phytomedicinal compounds in pericarp, skin and seeds of Momordica charantia (bitter melon). Natural Product Research 36:1, pages 390-395.
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Prajakta Kulkarni, Sathiyanarayanan Lohidasan & Kakasaheb Mahadik. (2021) Isolation, characterisation and investigation of in vitro antidiabetic and antioxidant activity of phytoconstituents from fruit of Momordica charantia Linn. Natural Product Research 35:6, pages 1035-1037.
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Farhan Saeed, Muhammad Afzaal, Bushra Niaz, Muhammad Umair Arshad, Tabussam Tufail, Muhammad Bilal Hussain & Ahsan Javed. (2018) Bitter melon (Momordica charantia): a natural healthy vegetable. International Journal of Food Properties 21:1, pages 1270-1290.
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Marie Carene Nancy Picot & Mohamad Fawzi Mahomoodally. (2017) Effects of Aphloia theiformis on key enzymes related to diabetes mellitus. Pharmaceutical Biology 55:1, pages 864-872.
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Xinlin Wei, Xuan Cai, Shuangli Xiong & Yuanfeng Wang. (2012) Hypoglycemic effect of oral crude tea flower polysaccharides on alloxan modeling Sprague–Dawley rats and the possible mechanism. CyTA - Journal of Food 10:4, pages 325-332.
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Articles from other publishers (33)

Muhammad Afnan Shakir Hairani, Fadzilah Adibah Abdul Majid, Nor Hafizah Zakaria, Dwi Hudiyanti, Anis Fadhlina & Hassan Ibrahim Sheikh. (2023) Anti-diabetic properties of traditional herbal concoction containing Eleutherine palmifolia (L.) Merr., Momordica charantia L., and Syzygium polyanthum (Wight.): a bibliometric analysis. Food Production, Processing and Nutrition 5:1.
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Parimalanandhini Duraisamy, Sangeetha Ravi, Mahalakshmi Krishnan, Livya Catherene Martin, Beulaja Manikandan, Thiagarajan Raman, Arumugam Munusamy & Manikandan Ramar. (2023) Scoparia dulcis and Indigofera tinctoria as potential herbal remedies against 7-ketocholesterol-induced pro-inflammatory mediators of macrophage polarization. Journal of Herbal Medicine 39, pages 100652.
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M. Bhagyalakshmi & S. Devaraja. 2023. Viral, Parasitic, Bacterial, and Fungal Infections. Viral, Parasitic, Bacterial, and Fungal Infections 209 220 .
Gograj Singh Jat, Tusar Kanti Behera & Umesh K. Reddy. 2023. Vegetables for Nutrition and Entrepreneurship. Vegetables for Nutrition and Entrepreneurship 141 177 .
Ali Hosseini Motlagh, Ali Nasirpour, Sima Saeidy & Javad Keramat. (2022) Physicochemical and sensory properties of malt beverage containing sugar beet saponins. Journal of Food Science and Technology 59:11, pages 4380-4389.
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Amy C. Keller, Kan He, Anne-Marie Brillantes & Edward J. Kennelly. (2021) A characterized saponin-rich fraction of Momordica charantia shows antidiabetic activity in C57BLK/6 mice fed a high fat diet. Phytomedicine Plus 1:4, pages 100134.
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Yufan Liu, Shumin Mu, Wenbin Chen, Shiyin Liu, Yuxuan Cong, Jiajia Liu & Ning Jia. (2021) Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway. Endocrinología, Diabetes y Nutrición 68:5, pages 329-337.
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Yufan Liu, Shumin Mu, Wenbin Chen, Shiyin Liu, Yuxuan Cong, Jiajia Liu & Ning Jia. (2021) Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway. Endocrinología, Diabetes y Nutrición (English ed.) 68:5, pages 329-337.
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Emanuel L. Peter, Prakash B. Nagendrappa, Anita Kaligirwa, Patrick Engeu Ogwang & Crispin Duncan Sesaazi. (2020) The safety and efficacy of Momordica charantia L. in animal models of type 2 diabetes mellitus: A systematic review and meta‐analysis . Phytotherapy Research 35:2, pages 637-656.
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Oluwamodupe C. Ejelonu, Simeon O. Oluba, Bankole O. Awolokun, Olusola O. Elekofehinti & Isaac G. Adanlawo. (2021) Saponin-rich extracts reverse obesity and offer protection against obesity-induced inflammation in high-fat diet mice. Journal of Medicinal Plants for Economic Development 5:1.
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Antara Banerjee, M.S. Pavane, L. Husaina Banu, A. Sai Rishika Gopikar, K. Roshini Elizabeth & Surajit Pathak. 2021. Stem Cells and Aging. Stem Cells and Aging 281 297 .
Shuang Jiang, Lei Xu, Yan Xu, Yushan Guo, Lin Wei, Xueting Li & Wu Song. (2020) Antidiabetic effect of Momordica charantia saponins in rats induced by high-fat diet combined with STZ. Electronic Journal of Biotechnology 43, pages 41-47.
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Abbirami Elangovan, Abinaya Subramanian, Siva Durairaj, Jeyadevi Ramachandran, Dinesh Kumar Lakshmanan, Guna Ravichandran, Gayathri Nambirajan & Sivasudha Thilagar. (2019) Antidiabetic and hypolipidemic efficacy of skin and seed extracts of Momordica cymbalaria on alloxan induced diabetic model in rats. Journal of Ethnopharmacology 241, pages 111989.
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Thi My Hanh Pham, Dai-Hung Ngo, Dai-Nghiep Ngo & Thanh Sang Vo. (2019) Investigation of Biological Activities of Wild Bitter Melon (Momordica charantia Linn. Var. Abbreviata Ser.). Biomolecules 9:6, pages 211.
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Luis Alberto Mejía-Manzano, Bertha A. Barba-Dávila, Patricia Vázquez-Villegas, Sergio O. Serna-Saldívar & José González-Valdez. (2019) Improved extraction of the natural anticancerigen pristimerin from Mortonia greggii root bark using green solvents and aqueous two-phase systems. Separation and Purification Technology 211, pages 667-672.
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Krishnamoorthy Vijayalakshmi & Chinnadurai Immanuel Selvaraj. (2018) Evaluation of Antidiabetic Potential of Sarcostemma brevistigma Wight & Arn. Using Alloxan-Induced Diabetic Murine Model. Applied Biochemistry and Biotechnology 187:1, pages 14-27.
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Shuo Jia, Mingyue Shen, Fan Zhang & Jianhua Xie. (2017) Recent Advances in Momordica charantia: Functional Components and Biological Activities. International Journal of Molecular Sciences 18:12, pages 2555.
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Oluwamodupe Cecilia Ejelonu, Olusola Olalekan Elekofehinti & Isaac Gbadura Adanlawo. (2017) Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats. Biomedicine & Pharmacotherapy 87, pages 589-595.
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Isabel M. Marrucho & Mara G. Freire. 2016. Ionic Liquids for Better Separation Processes. Ionic Liquids for Better Separation Processes 91 119 .
Yao Zhang, Chunjiu Ren, Guobing Lu, Weizheng Cui, Zhimei Mu, Huiju Gao & Yanwen Wang. (2014) Purification, characterization and anti-diabetic activity of a polysaccharide from mulberry leaf. Regulatory Toxicology and Pharmacology 70:3, pages 687-695.
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Sing P. Tan, Quan V. Vuong, Costas E. Stathopoulos, Sophie E. Parks & Paul D. Roach. (2014) Optimized Aqueous Extraction of Saponins from Bitter Melon for Production of a Saponin-Enriched Bitter Melon Powder. Journal of Food Science 79:7, pages E1372-E1381.
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Hsien-Yi Wang, Wei-Chih Kan, Tain-Junn Cheng, Sung-Hsun Yu, Liang-Hao Chang & Jiunn-Jye Chuu. (2014) Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice. Food and Chemical Toxicology 69, pages 347-356.
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Bernardo D. Ribeiro, Maria Alice Z. Coelho, Luis Paulo N. Rebelo & Isabel M. Marrucho. (2013) Ionic Liquids as Additives for Extraction of Saponins and Polyphenols from Mate (Ilex paraguariensis) and Tea (Camellia sinensis). Industrial & Engineering Chemistry Research 52:34, pages 12146-12153.
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George Q. Li, Antony Kam, Ka H. Wong, Xian Zhou, Eshaifol A. Omar, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski & Kelvin Chan. 2013. Diabetes. Diabetes 396 413 .
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Nasir S. A. Malik, Jose L. Perez & Madhurababu Kunta. (2012) The effect of leaf presence on the rooting of stem cutting of bitter melon and on changes in polyamine levels. Agricultural Sciences 03:07, pages 936-940.
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Wadie I. Najm. 2012. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome 355 365 .
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Fabiola Rivera-Ramírez, Gerardo N. Escalona-Cardoso, Leticia Garduño-Siciliano, Carlos Galaviz-Hernández & Norma Paniagua-Castro. (2011) Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose . Journal of Biomedicine and Biotechnology 2011, pages 1-6.
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