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Natural Product Research
Formerly Natural Product Letters
Volume 23, 2009 - Issue 4
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Original Articles

Cholinesterase inhibitors from Sargassum and Gracilaria gracilis: Seaweeds inhabiting South Indian coastal areas (Hare Island, Gulf of Mannar)

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Pages 355-369 | Received 19 Sep 2007, Accepted 24 Apr 2008, Published online: 29 Oct 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Luísa Custódio, Laura Silvestre, Maria Isabel Rocha, Maria João Rodrigues, Catarina Vizetto-Duarte, Hugo Pereira, Luísa Barreira & João Varela. (2016) Methanol extracts from Cystoseira tamariscifolia and Cystoseira nodicaulis are able to inhibit cholinesterases and protect a human dopaminergic cell line from hydrogen peroxide-induced cytotoxicity. Pharmaceutical Biology 54:9, pages 1687-1696.
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Arif Nisha Syad, Karutha Pandian Shunmugiah & Pandima Devi Kasi. (2013) Antioxidant and anti-cholinesterase activity of Sargassum wightii. Pharmaceutical Biology 51:11, pages 1401-1410.
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Articles from other publishers (34)

Leonel Pereira & Ana Valado. (2023) From the ocean to the brain: harnessing the power of marine algae for neuroprotection and therapeutic advances. Exploration of Neuroprotective Therapy, pages 409-428.
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Dang Diem Hong, Le Thi Thom, Nguyen Cam Ha, Ngo Thi Hoai Thu, Hoang Thi Minh Hien, Luu Thi Tam, Nguyen Manh Dat, Tran Mai Duc, Nguyen Van Tru, Nguyen Thi Minh Hang & Ranga Rao Ambati. (2023) Isolation of Fucoxanthin from Sargassum oligocystum Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity. Biomedicines 11:8, pages 2310.
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Arghavan Hosseinpouri, Mehdi Mohammadi, Elham Ehsandoost, Paria Sharafi-Badr & Narges Obeidi. (2023) Chemical identification, antioxidant, cholinesterase inhibitory, and cytotoxic properties of fucoidan extracted from Persian Gulf Sargassum angustifolium. Acta Oceanologica Sinica 41:12, pages 133-141.
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Luana Kamarowski Lins Alves, Valdir Cechinel Filho, Ricardo Lehtonen Rodrigues de Souza & Lupe Furtado-Alle. (2022) BChE inhibitors from marine organisms – A review. Chemico-Biological Interactions 367, pages 110136.
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Farid Menaa, Udari Wijesinghe, Gobika Thiripuranathar, Norah A. Althobaiti, Aishah E. Albalawi, Barkat Ali Khan & Bouzid Menaa. (2021) Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?. Marine Drugs 19:9, pages 484.
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Ipek Baysal, Melike Ekizoglu, Abdulselam Ertas, Burak Temiz, Hale Gamze Agalar, Samiye Yabanoglu-Ciftci, Hamdi Temel, Gulberk Ucar & Fatma Pinar Turkmenoglu. (2021) Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum. Molecules 26:13, pages 4040.
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Carla O. Silva, Tiago Simões, Rafael Félix, Amadeu M.V.M. Soares, Carlos Barata, Sara C. Novais & Marco F.L. Lemos. (2021) Asparagopsis armata Exudate Cocktail: The Quest for the Mechanisms of Toxic Action of an Invasive Seaweed on Marine Invertebrates. Biology 10:3, pages 223.
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Leonel Pereira & Ana Valado. (2021) The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases. Marine Drugs 19:3, pages 128.
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Alexander V. Prazukin, Elena V. Anufriieva & Nickolai V. Shadrin. (2020) Is biomass of filamentous green algae Cladophora spp. (Chlorophyta, Ulvophyceae) an unlimited cheap and valuable resource for medicine and pharmacology? A review . Reviews in Aquaculture 12:4, pages 2493-2510.
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Rabia Bibi, Rajput Muhammad Tariq & Munawwer Rasheed. (2020) Toxic assessment, growth disrupting and neurotoxic effects of red seaweeds’ botanicals against the dengue vector mosquito Aedes aegypti L.. Ecotoxicology and Environmental Safety 195, pages 110451.
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Tosin A. Olasehinde, Ademola O. Olaniran & Anthony I. Okoh. (2019) Neuroprotective effects of some seaweeds against Zn – induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity. Metabolic Brain Disease 34:6, pages 1615-1627.
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Eun-A Kim, Seo-Young Kim, Junseong Kim, Jae-Young Oh, Hyun-Soo Kim, Weon-Jong Yoon, Do-Hyung Kang & Soo-Jin Heo. (2019) Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model. Journal of Functional Foods 52, pages 109-115.
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Priscila Torres, Janaína Pires Santos, Fungyi Chow & Déborah Y.A.C. dos Santos. (2019) A comprehensive review of traditional uses, bioactivity potential, and chemical diversity of the genus Gracilaria (Gracilariales, Rhodophyta). Algal Research 37, pages 288-306.
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Mohamed A. Shreadah, Nehad M. Abd El Moneam, Samy A. Al-Assar & Asmaa Nabil-Adam. (2018) Phytochemical and pharmacological screening of Sargassium vulgare from Suez Canal, Egypt. Food Science and Biotechnology 27:4, pages 963-979.
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Susete Pinteus, Marco Lemos, Joana Silva, Celso Alves, Agnieszka Neugebauer, Rafaela Freitas, Adriana Duarte & Rui Pedrosa. (2017) An Insight into Sargassum muticum Cytoprotective Mechanisms against Oxidative Stress on a Human Cell In Vitro Model. Marine Drugs 15:11, pages 353.
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Pirzada Jamal Ahmed Siddiqui, Adnan Khan, Nizam Uddin, Saima Khaliq, Munawwer Rasheed, Shazia Nawaz, Ahsana Dar & Muhammad Hanif. (2017) Sargassum swartzii extracts ameliorate memory functions by neurochemical modulation in a rat model. Food Science and Biotechnology 26:4, pages 1055-1062.
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M.I. Rocha, M.J. Rodrigues, C. Pereira, H. Pereira, M.M. da Silva, N. da Rosa Neng, J.M.F. Nogueira, J. Varela, L. Barreira & L. Custódio. (2017) Biochemical profile and in vitro neuroprotective properties of Carpobrotus edulis L., a medicinal and edible halophyte native to the coast of South Africa. South African Journal of Botany 111, pages 222-231.
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Alfred Maroyi. (2017) Traditional usage, phytochemistry and pharmacology of Croton sylvaticus Hochst. ex C. Krauss. Asian Pacific Journal of Tropical Medicine 10:5, pages 423-429.
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Fook Yee Chye, Birdie Scott Padam & Seah Young Ng. 2017. Sustainability Challenges in the Agrofood Sector. Sustainability Challenges in the Agrofood Sector 390 434 .
Tosin Olasehinde, Ademola Olaniran & Anthony Okoh. (2017) Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease. Molecules 22:3, pages 480.
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María Figueiredo-González, Patrícia Valentão & Paula B. Andrade. (2016) Tomato plant leaves: From by-products to the management of enzymes in chronic diseases. Industrial Crops and Products 94, pages 621-629.
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P. Déléris, H. Nazih & J.-M. Bard. 2016. Seaweed in Health and Disease Prevention. Seaweed in Health and Disease Prevention 319 367 .
Levi P. Machado, Luciana R. Carvalho, Maria Cláudia M. Young, Elaine M. Cardoso-Lopes, Danilo C. Centeno, Leonardo Zambotti-Villela, Pio Colepicolo & Nair S. Yokoya. (2015) Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts. Revista Brasileira de Farmacognosia 25:6, pages 657-662.
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Malek Besbes Hlila, Habib Mosbah, Kamel Mssada, Hichem Ben Jannet, Mahjoub Aouni & Boulbaba Selmi. (2015) Acetylcholinesterase inhibitory and antioxidant properties of roots extracts from the Tunisian Scabiosa arenaria Forssk. Industrial Crops and Products 67, pages 62-69.
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Luísa Custódio, João Patarra, Fernando Alberício, Nuno da Rosa Neng, José Manuel Florêncio Nogueira & Anabela Romano. (2015) Phenolic composition, antioxidant potential and in vitro inhibitory activity of leaves and acorns of Quercus suber on key enzymes relevant for hyperglycemia and Alzheimer's disease. Industrial Crops and Products 64, pages 45-51.
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Ke-Xin Yu, Ibrahim Jantan, Rohani Ahmad & Ching-Lee Wong. (2014) The major bioactive components of seaweeds and their mosquitocidal potential. Parasitology Research 113:9, pages 3121-3141.
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Arthitaya Kawee-ai, Ampin Kuntiya & Sang Moo Kim. (2013) Anticholinesterase and Antioxidant Activities of Fucoxanthin Purified from the Microalga Phaeodactylum Tricornutum . Natural Product Communications 8:10, pages 1934578X1300801.
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Mutalib A. Aderogba, Ashwell R. Ndhlala & Johannes Van Staden. (2013) Acetylcholinesterase Inhibitors from Croton sylvaticus Ethyl Acetate Leaf Extract and their Mutagenic Effects . Natural Product Communications 8:6, pages 1934578X1300800.
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Luísa Custódio, João Patarra, Fernando Alberício, Nuno Rosa Neng, José Manuel Florêncio Nogueira & Anabela Romano. (2013) Extracts from Quercus sp. acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SH-SY5Y from hydrogen peroxide-induced cytotoxicity. Industrial Crops and Products 45, pages 114-120.
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M Sundaram. (2012) Antitumor activity of ethanol extract of Gracilaria edulis (Gmelin) Silva on Ehrlich ascites carcinoma-bearing mice. Journal of Chinese Integrative Medicine 10:4, pages 430-435.
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Luísa Custódio, Tiago Justo, Laura Silvestre, Ana Barradas, Catarina Vizetto Duarte, Hugo Pereira, Luísa Barreira, Amélia Pilar Rauter, Fernando Alberício & João Varela. (2012) Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities. Food Chemistry 131:1, pages 134-140.
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Suhaila Mohamed, Siti Nadia Hashim & Hafeedza Abdul Rahman. (2012) Seaweeds: A sustainable functional food for complementary and alternative therapy. Trends in Food Science & Technology 23:2, pages 83-96.
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Philip Williams, Analia Sorribas & Melanie-Jayne R. Howes. (2011) Natural products as a source of Alzheimer's drug leads. Nat. Prod. Rep. 28:1, pages 48-77.
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N. Suganthy, S. Karutha Pandian & K. Pandima Devi. (2010) Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neuroscience Letters 468:3, pages 216-219.
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