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Natural Product Research
Formerly Natural Product Letters
Volume 28, 2014 - Issue 23
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Review

Pueraria tuberosa: a review on its phytochemical and therapeutic potential

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Pages 2111-2127 | Received 22 Apr 2014, Accepted 22 May 2014, Published online: 01 Jul 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Priya Shree, Priyanka Mishra, Prateek Kumar, Harsh Pandey, Rajanish Giri, Radha Chaube, Neha Garg & Yamini Bhusan Tripathi. (2022) In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets Mpro and TMPRSS2. Journal of Biomolecular Structure and Dynamics 40:22, pages 11611-11624.
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Bashir Ahmad, Suliman Khan, Yang Liu, Mengzhou Xue, Ghulam Nabi, Sunjeet Kumar, Mohammed Alshwmi & Abdul Wakeel Qarluq. (2020) Molecular Mechanisms of Anticancer Activities of Puerarin. Cancer Management and Research 12, pages 79-90.
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Swaha Satpathy, Arjun Patra, Bharti Ahirwar & Muhammad Delwar Hussain. (2018) Antioxidant and anticancer activities of green synthesized silver nanoparticles using aqueous extract of tubers of Pueraria tuberosa. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 71-85.
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Articles from other publishers (48)

Harinder Singh, Priyanka KriplaniSweta Kamboj & Kumar Guarve. (2024) Puerarin: An Anticancer and Anti-Inflammatory Agent. Recent Patents on Anti-Cancer Drug Discovery 19:1, pages 18-36.
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Nitin M. Atre & Dinesh D. Khedkar. (2023) Herbal remedies for respiratory ailments from Melghat region: a review with relevance to COVID-19 symptoms. Journal of Herbal Medicine 42, pages 100744.
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Ajeet Singh, Amit Kumar Bundela & Purushothaman Chirakkuzhyil Abhilash. (2023) Nutritional, Ethnomedicinal, and Agricultural Significance of Neglected and Underutilized Crops from Eastern Uttar Pradesh, North India. Agronomy 13:9, pages 2318.
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Hai-Tao Li, Kun Zhong, Yun-Fei Xia, Jian Song, Xiao-Qing Chen, Wei Zhao, Xu-Hui Zeng & Tian-Xing Chen. (2023) Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways. Biomedicine & Pharmacotherapy 165, pages 115231.
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Qi Sheng, Xinzhuan Yao, Hufang Chen, Hu Tang & Litang Lu. (2023) Identification of Nutritional Ingredients and Medicinal Components of Hawk Tea and Insect Tea Using Widely Targeted Secondary Metabolomics. Horticulturae 9:4, pages 457.
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Atul Arya, Suresh Kumar, Rajinder Paul, Amrita Suryavanshi, Dolly Kain & Rudra Narayan Sahoo. (2021) Ethnopharmacological survey of indigenous medicinal plants of Palampur, Himachal Pradesh in north-western Himalaya, India. Advances in Traditional Medicine 23:1, pages 169-212.
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Nidhi Likhitker & Dr. Priyanka Tiwari. (2023) Extraction and Qualitative Analysis of Alternanthera Sessils and Pueraria Tuberosa. International Journal of Advanced Research in Science, Communication and Technology, pages 209-213.
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Ai-Wen Kang, Chi Sun, Hai-Tao Li, Kun Zhong, Xu-Hui Zeng, Zhi-Feng Gu, Bing-Qian Li, Xiao-Ning Zhang, Jian-Lin Gao & Tian-Xing Chen. (2023) Puerarin extends the lifespan of Drosophila melanogaster by activating autophagy . Food & Function 14:4, pages 2149-2161.
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Yameng Zhu, Mengmeng Zhang, Shujie Wei, Boyao Wang, Jun He & Xilong Qiu. (2022) Temperature-responsive P(NIPAM-co-NHMA)-grafted organic-inorganic hybrid hollow mesoporous silica nanoparticles for controlled drug delivery. Journal of Drug Delivery Science and Technology 70, pages 103197.
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Saied A. Aboushanab, Vadim A. Shevyrin, Grigory P. Slesarev, Vsevolod V. Melekhin, Anna V. Shcheglova, Oleg G. Makeev, Elena G. Kovaleva & Ki Hyun Kim. (2022) Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS. Plants 11:6, pages 741.
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Huikai Shao, Yang Huang, Dongsheng Xu, Shengfeng Huang & Rongsheng Tong. (2022) A Systematic Review and Meta-Analysis on the Efficacy of Puerarin Injection as Adjunctive Therapy for Unstable Angina Pectoris. Frontiers in Cardiovascular Medicine 9.
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Li Jiang, Yanling Xiong, Yu Tu, Wentong Zhang, Qiyun Zhang, Peng Nie, Xiaojun Yan, Hongning Liu, Ronghua Liu & Guoliang Xu. (2022) Elucidation of the Transport Mechanism of Puerarin and Gastrodin and Their Interaction on the Absorption in a Caco-2 Cell Monolayer Model. Molecules 27:4, pages 1230.
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Heng He, Shuwei Peng, Xu Song, Renyong Jia, Yuanfeng Zou, Lixia Li & Zhongqiong Yin. (2021) Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review. Food Science & Nutrition 10:1, pages 272-285.
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Xiaohong Shang, Ding Huang, Ying Wang, Liang Xiao, Ruhong Ming, Wendan Zeng, Sheng Cao, Liuying Lu, Zhengdan Wu & Huabing Yan. (2021) Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics. Molecules 26:21, pages 6587.
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Li Bin, Luo Bing, Liu Yan-de & Wu Jian. (2021) Detection of adulteration of kudzu powder by terahertz time-domain spectroscopy. Journal of Food Measurement and Characterization 15:5, pages 4380-4387.
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Anami Ahuja, Pankaj Kumar Tyagi, Shruti Tyagi, Anuj Kumar, Manoj Kumar & Javad Sharifi-Rad. (2021) Potential of Pueraria tuberosa (Willd.) DC. to rescue cognitive decline associated with BACE1 protein of Alzheimer's disease on Drosophila model: An integrated molecular modeling and in vivo approach. International Journal of Biological Macromolecules 179, pages 586-600.
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Bhanupriya Kanthaliya, Abhishek Joshi, Supriya Meena & Jaya Arora. 2021. Medicinal Plants. Medicinal Plants 693 719 .
Sulochana Kaushik, Samander Kaushik, Ramesh Kumar, Lalit Dar & Jaya Parkash Yadav. (2020) In-vitro and in silico activity of Cyamopsis tetragonoloba (Gaur) L. supercritical extract against the dengue-2 virus. VirusDisease 31:4, pages 470-478.
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Yangyang Wang, Bo Pan, Mingjun Zhang, Xinpeng Du, Weihong Wu, Li Fu, Qinwei Zhou & Yuhong Zheng. (2020) Electrochemical Profile Recording for Pueraria Variety Identification. Analytical Sciences 36:10, pages 1237-1241.
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Yunfei Lai, Hexiu Quan, Feng Shao, Xiaowei Meng, Weifeng Zhu, Puzhao Zhang & Ronghua Liu. (2020) Three new isoflavones from Pueraria thomsonii Benth and their protective effects on H2O2-induced oxidative injury in H9c2 cardiomyocytes. Phytochemistry Letters 39, pages 90-93.
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Mingjun Zhang, Bo Pan, Yangyang Wang, Xinpeng Du, Li Fu, Yuhong Zheng, Fei Chen, Weihong Wu, Qinwei Zhou, Su Ding & Shichao Zhao. (2020) Recording the Electrochemical Profile of Pueraria Leaves for Polyphyly Analysis . ChemistrySelect 5:17, pages 5035-5040.
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Xu Chen, Ziyu He, Xianyong Wu, Dongsheng Mao, Chang Feng, Juan Zhang & Guifang Chen. (2020) Comprehensive study of the interaction between Puerariae Radix flavonoids and DNA: From theoretical simulation to structural analysis to functional analysis. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 231, pages 118109.
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Rajeev K. Singla, Rishabh Kumar, Sameer Khan, Mohit, Kajal Kumari & Arun Garg. (2019) Natural Products: Potential Source of DPP-IV Inhibitors. Current Protein & Peptide Science 20:12, pages 1218-1225.
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Swati Vyas, S.L. Kothari & Sumita Kachhwaha. (2019) Nootropic medicinal plants: Therapeutic alternatives for Alzheimer’s disease. Journal of Herbal Medicine 17-18, pages 100291.
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Bhanupriya Kanthaliya, Abhishek Joshi & Jaya Arora. (2019) Evaluation of isoflavonoid content in context to tuber size and seed biology study of Pueraria tuberosa (Roxb.ex.Willd.) DC: a vulnerable medicinal plant. Vegetos 32:3, pages 247-253.
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Da-Cheng Hao & Pei-gen Xiao. (2019) Impact of Drug Metabolism/Pharmacokinetics and their Relevance Upon Traditional Medicine-based Cardiovascular Drug Research. Current Drug Metabolism 20:7, pages 556-574.
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Rashmi Shukla, Somanshu Banerjee & Yamini B. Tripathi. (2018) Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complementary and Alternative Medicine 18:1.
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Dibyendu Das, Sanjib Sarkar, Jijnasa Bordoloi, Sawlang Borsingh Wann, Jatin Kalita & Prasenjit Manna. (2018) Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes. BioFactors 44:5, pages 407-417.
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Xing-Xin Yang, Yu-Zhen Zhou, Feng Xu, Jie Yu, Gegentana, Ming-Ying Shang, Xuan Wang & Shao-Qing Cai. (2018) Screening potential mitochondria-targeting compounds from traditional Chinese medicines using a mitochondria-based centrifugal ultrafiltration/liquid chromatography/mass spectrometry method. Journal of Pharmaceutical Analysis 8:4, pages 240-249.
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Rashmi Shukla, Somanshu Banerjee & Yamini B Tripathi. (2018) Pueraria tuberosa extract inhibits iNOS and IL-6 through suppression of PKC-α and NF-kB pathway in diabetes-induced nephropathy . Journal of Pharmacy and Pharmacology 70:8, pages 1102-1112.
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Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Shang He, Jingwen Chen & Chengbin Wang. (2018) Mechanism of aquaporin 4 (AQP 4) up-regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin. Life Sciences 193, pages 270-281.
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Zimei Shan, Na Cheng, Rong Huang, Bin Zhao & Yali Zhou. (2017) Puerarin promotes the proliferation and differentiation of MC3T3-E1 cells via microRNA‑106b by targeting receptor activator of nuclear factor‑κB ligand. Experimental and Therapeutic Medicine.
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Zhen Wu, Jing Wu, Ping Fang & Shifeng Kan. (2017) Puerarin increases the chemosensitivity of hepatocellular carcinoma cells. Oncology Letters 14:3, pages 3006-3010.
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Rashmi Shukla, Nidhi Pandey, Somanshu Banerjee & Yamini B. Tripathi. (2017) Effect of extract of Pueraria tuberosa on expression of hypoxia inducible factor-1α and vascular endothelial growth factor in kidney of diabetic rats. Biomedicine & Pharmacotherapy 93, pages 276-285.
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Feng Liang & Shenggao Xie. (2017) Puerarin prevents tumor necrosis factor-α-induced apoptosis of PC12 cells via activation of the PI3K/Akt signaling pathway. Experimental and Therapeutic Medicine 14:1, pages 813-818.
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Yamini B. Tripathi, Rashmi Shukla, Nidhi Pandey, Vivek Pandey & Mohan Kumar. (2016) An extract of Pueraria tuberosa tubers attenuates diabetic nephropathy by upregulating matrix metalloproteinase‐9 expression in the kidney of diabetic rats . Journal of Diabetes 9:2, pages 123-132.
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Xiao Ling, Yuqiang Xiang, Qingfa Tang, Zhen Jin, Feilong Chen & Xiaomei Tan. (2017) Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-11.
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Rong Li, Jianhua Song, Wei Wu, Xinmou Wu & Min Su. (2016) Puerarin exerts the protective effect against chemical induced dysmetabolism in rats. Gene 595:2, pages 168-174.
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Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Xu Guan, Jingwen Chen & Chengbin Wang. (2016) Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-κB signaling pathway. International Immunopharmacology 40, pages 300-309.
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Rufeng Ma, Ruyuan Zhu, Lili Wang, Yubo Guo, Chenyue Liu, Haixia Liu, Fengwei Liu, Hongjun Li, Yu Li, Min Fu & Dongwei Zhang. (2016) Diabetic Osteoporosis: A Review of Its Traditional Chinese Medicinal Use and Clinical and Preclinical Research. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-13.
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Wen Xiao, Cen Chen, Qian Zhang, Qi-Hui Zhang, Yuan-Jia Hu, Zhi-Ning Xia & Feng-Qing Yang. (2015) Separation Study of Eight Isoflavones by MEKC with Different Surfactants. Chromatographia 78:21-22, pages 1385-1393.
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Heng Zhang, Zhenhua Zhai, Hongyu Zhou, Yao Li, Xiaojie Li, Yuhan Lin, Weihong Li, Yueping Shi & Ming-Sheng Zhou. (2015) Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage. BioMed Research International 2015, pages 1-8.
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Yameng Zhu, Mengmeng Zhang, Shujie Wei, Boyao Wang, Jun He & Xilong Qiu. (2021) Temperature-Responsive P(NIPAM- <i>co</i>-NHMA)-Grafted Organic-Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery. SSRN Electronic Journal.
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