1,438
Views
54
CrossRef citations to date
0
Altmetric
Review

The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?

, &
Pages 747-763 | Received 08 Apr 2016, Accepted 20 Jun 2016, Published online: 15 Jul 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Saikat Mitra, Sifat Ara Sultana, Shajuthi Rahman Prova, Tanvir Mahtab Uddin, Fahadul Islam, Rajib Das, Firzan Nainu, Sartini Sartini, Kumarappan Chidambaram, Fahad A. Alhumaydhi, Talha Bin Emran & Jesus Simal-Gandara. (2022) Investigating forthcoming strategies to tackle deadly superbugs: current status and future vision. Expert Review of Anti-infective Therapy 20:10, pages 1309-1332.
Read now
Na Huang, Tao Chen, Liqiong Chen, Ying Zhang, Yishuai Lin, Xiangkuo Zheng, Tieli Zhou & Lijiang Chen. (2021) In vitro Activity of Meropenem-Vaborbactam versus Other Antibiotics Against Carbapenem-Resistant Escherichia coli from Southeastern China. Infection and Drug Resistance 14, pages 2499-2507.
Read now
Liqiong Chen, Kaihang Yu, Lijiang Chen, Xiangkuo Zheng, Na Huang, Yishuai Lin, Huaiyu Jia, Wenli Liao, Jianming Cao & Tieli Zhou. (2021) Synergistic Activity and Biofilm Formation Effect of Colistin Combined with PFK-158 Against Colistin-Resistant Gram-Negative Bacteria. Infection and Drug Resistance 14, pages 2143-2154.
Read now
Guilherme Felipe dos Santos Fernandes, Hérida Regina Nunes Salgado & Jean Leandro dos Santos. (2020) A critical review of HPLC-based analytical methods for quantification of Linezolid. Critical Reviews in Analytical Chemistry 50:3, pages 196-211.
Read now
Zhihui Jiang, Xianxia He & Jian Li. (2018) Synergy effect of meropenem-based combinations against Acinetobacter baumannii: a systematic review and meta-analysis. Infection and Drug Resistance 11, pages 1083-1095.
Read now
Konstantinos Z. Vardakas, Georgios D. Kalimeris, Nikolaos A. Triarides & Matthew E. Falagas. (2018) An update on adverse drug reactions related to β-lactam antibiotics. Expert Opinion on Drug Safety 17:5, pages 499-508.
Read now
Alberto Bonetta, Giandomenico Roviello, Daniele Generali, Laura Zanotti, Maria Rosa Cappelletti, Chiara Pacifico & Francesco Di Pierro. (2017) Enteric-coated and highly standardized cranberry extract reduces antibiotic and nonsteroidal anti-inflammatory drug use for urinary tract infections during radiotherapy for prostate carcinoma. Research and Reports in Urology 9, pages 65-69.
Read now
Alexandre P. Zavascki, Brandon O. Klee & Jürgen B. Bulitta. (2017) Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility. Expert Review of Anti-infective Therapy 15:6, pages 519-526.
Read now

Articles from other publishers (45)

Hang Thi Nguyen, Henrietta Venter, Lucy Woolford, Kelly A. Young, Adam McCluskey, Sanjay Garg, Sylvia S. Sapula, Stephen W. Page, Abiodun David Ogunniyi & Darren J. Trott. (2023) Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces Staphylococcus aureus infection and reduces Escherichia coli infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model . Antimicrobial Agents and Chemotherapy 67:10.
Crossref
Samar S. Mabrouk, Ghada R. Abdellatif, Ahmed S. Abu Zaid & Khaled M. Aboshanab. (2023) Propranolol restores susceptibility of XDR Gram-negative pathogens to meropenem and Meropenem combination has been evaluated with either tigecycline or amikacin. BMC Microbiology 23:1.
Crossref
Jiawei Chen, Yong Liu, Wei Jia, Xuesong Xu, Guizhen Sun, Tong Wang, Jin Li, Ge Zhang, Ran Jing, Hongli Sun, Yingchun Xu & Yali Liu. (2023) In Vitro Activities of Aztreonam-Avibactam, Eravacycline, Cefoselis, and Other Comparators against Clinical Enterobacterales Isolates: a Multicenter Study in China, 2019 . Microbiology Spectrum 11:3.
Crossref
Shio-Shin Jean, I-Min Liu, Po-Chuen Hsieh, Dai-Huang Kuo, Yi-Lien Liu & Po-Ren Hsueh. (2023) Off-label use versus formal recommendations of conventional and novel antibiotics for the treatment of infections caused by multidrug-resistant bacteria. International Journal of Antimicrobial Agents 61:5, pages 106763.
Crossref
Jian Sun, Lili He, Jingwen Ji, Lijuan Zhai, Jinbo Ji, Xueqin Ma, Dong Tang, Yangxiu Mu, Yuanyu Gao, Lin Wang, Haikang Yang, Zafar Iqbal & Zhixiang Yang. (2022) Synergistic Antibacterial Activity of Meropenem and Imipenem in Combination with Diazabicyclooctane Derivatives. Russian Journal of General Chemistry 92:10, pages 2070-2081.
Crossref
Zafar Iqbal, Jian Sun, Haikang Yang, Jingwen Ji, Lili He, Lijuan Zhai, Jinbo Ji, Pengjuan Zhou, Dong Tang, Yangxiu Mu, Lin Wang & Zhixiang Yang. (2022) Recent Developments to Cope the Antibacterial Resistance via β-Lactamase Inhibition. Molecules 27:12, pages 3832.
Crossref
Lucia Rose, Lauren Lai & Dana Byrne. (2022) Successful prolonged treatment of a carbapenem‐resistant Acinetobacter baumannii hip infection with cefiderocol: A case report . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 42:3, pages 268-271.
Crossref
Matteo Bassetti, Daniele Roberto Giacobbe, Nadia Castaldo, Alessandro Russo & Antonio Vena. (2021) Role of new antibiotics in extended-spectrum β-lactamase-, AmpC- infections. Current Opinion in Infectious Diseases 34:6, pages 748-755.
Crossref
Lili He, Lijuan Zhai, Jian Sun, Jingwen Ji, Jinbo Ji, Yuanbai Liu, Yangxiu Mu, Yuanyu Gao, Dong Tang, Rui Jiang, Ko Ko Myo, Zaw Min Thu, Haikang Yang, Zafar Iqbal & Zhixiang Yang. (2021) Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile. Journal of Chemistry 2021, pages 1-11.
Crossref
Tao ChenWenya XuKaihang YuWeiliang ZengChunquan XuJianming CaoTieli Zhou. (2021) In Vitro Activity of Ceftazidime-Avibactam Alone and in Combination with Amikacin Against Colistin-Resistant Gram-Negative Pathogens . Microbial Drug Resistance 27:3, pages 401-409.
Crossref
Saroj Sharma, Monalisa Tiwari & Vishvanath Tiwari. (2021) Therapeutic strategies against autophagic escape by pathogenic bacteria. Drug Discovery Today 26:3, pages 704-712.
Crossref
Louis Koeninger, Lisa Osbelt, Anne Berscheid, Judith Wendler, Jürgen Berger, Katharina Hipp, Till R. Lesker, Marina C. Pils, Nisar P. Malek, Benjamin A. H. Jensen, Heike Brötz-Oesterhelt, Till Strowig & Jan Wehkamp. (2021) Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota. Communications Biology 4:1.
Crossref
Mohammad Saydur Rahman & Young-Sang Koh. (2020) A Novel Antibiotic Agent, Cefiderocol, for Multidrug-Resistant Gram-Negative Bacteria. Journal of Bacteriology and Virology 50:4, pages 218-226.
Crossref
Matteo Bassetti, Daniele R. Giacobbe, Chiara Robba, Paolo Pelosi & Antonio Vena. (2020) Treatment of extended-spectrum β-lactamases infections: what is the current role of new β-lactams/β-lactamase inhibitors?. Current Opinion in Infectious Diseases 33:6, pages 474-481.
Crossref
Fredy Alexander Guevara Agudelo, Liliana Constanza Muñoz Molina, Jeannette Navarrette Ospina, Luz Mary Salazar Pulido & Gladys Pinilla Bermúdez. (2020) Innovaciones en la terapia antimicrobiana. Nova 18:34, pages 9-25.
Crossref
Dirk Ehmann, Louis Koeninger, Judith Wendler, Nisar P. Malek, Eduard F. Stange, Jan Wehkamp & Benjamin A. H. Jensen. (2020) Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria. Frontiers in Microbiology 11.
Crossref
Matthew W. McCarthy. (2020) Clinical Pharmacokinetics and Pharmacodynamics of Imipenem–Cilastatin/Relebactam Combination Therapy. Clinical Pharmacokinetics 59:5, pages 567-573.
Crossref
Ian Morrissey, Stephen Hawser, Sibylle H. Lob, James A. Karlowsky, Matteo Bassetti, G. Ralph Corey, Melanie Olesky, Joseph Newman & Corey Fyfe. (2020) In Vitro Activity of Eravacycline against Gram-Positive Bacteria Isolated in Clinical Laboratories Worldwide from 2013 to 2017 . Antimicrobial Agents and Chemotherapy 64:3.
Crossref
Ian Morrissey, Melanie Olesky, Stephen Hawser, Sibylle H. Lob, James A. Karlowsky, G. Ralph Corey, Matteo Bassetti & Corey Fyfe. (2020) In Vitro Activity of Eravacycline against Gram-Negative Bacilli Isolated in Clinical Laboratories Worldwide from 2013 to 2017 . Antimicrobial Agents and Chemotherapy 64:3.
Crossref
Andraž Lamut, Cristina D. Cruz, Žiga Skok, Michaela Barančoková, Nace Zidar, Anamarija Zega, Lucija Peterlin Mašič, Janez Ilaš, Päivi Tammela, Danijel Kikelj & Tihomir Tomašič. (2020) Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates. Bioorganic Chemistry 95, pages 103550.
Crossref
Antonio Vena, Nadia Castaldo & Matteo Bassetti. (2019) The role of new β-lactamase inhibitors in gram-negative infections. Current Opinion in Infectious Diseases 32:6, pages 638-646.
Crossref
Frank Schweizer. 2019. Antibiotic Drug Resistance. Antibiotic Drug Resistance 453 476 .
Catherine L. Tooke, Philip Hinchliffe, Eilis C. Bragginton, Charlotte K. Colenso, Viivi H.A. Hirvonen, Yuiko Takebayashi & James Spencer. (2019) β-Lactamases and β-Lactamase Inhibitors in the 21st Century. Journal of Molecular Biology 431:18, pages 3472-3500.
Crossref
Konstantinos Z. Vardakas, Florentia Athanassaki, Vassiliki Pitiriga & Matthew E. Falagas. (2019) Clinical relevance of in vitro synergistic activity of antibiotics for multidrug-resistant Gram-negative infections: A systematic review. Journal of Global Antimicrobial Resistance 17, pages 250-259.
Crossref
Matthew E. Falagas, Georgios L. Voulgaris, Kyriaki Tryfinopoulou, Panagiota Giakkoupi, Margarita Kyriakidou, Alkiviadis Vatopoulos, Anthony Coates & Yanmin Hu. (2019) Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals. International Journal of Antimicrobial Agents 53:6, pages 855-858.
Crossref
Shio-Shin Jean, Ian M. Gould, Wen-Sen Lee & Po-Ren Hsueh. (2019) New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship. Drugs 79:7, pages 705-714.
Crossref
Ronald Domalaon, P. Malaka De Silva, Ayush Kumar, George G. Zhanel & Frank Schweizer. (2019) The Anthelmintic Drug Niclosamide Synergizes with Colistin and Reverses Colistin Resistance in Gram-Negative Bacilli. Antimicrobial Agents and Chemotherapy 63:4.
Crossref
Alessandra Oliva, Stefania Garzoli, Massimiliano De Angelis, Carolina Marzuillo, Vincenzo Vullo, Claudio Mastroianni & Rino Ragno. (2019) In-Vitro Evaluation of Different Antimicrobial Combinations with and without Colistin Against Carbapenem-Resistant Acinetobacter Baumannii. Molecules 24:5, pages 886.
Crossref
Meenakshi M. Rana, Paolo Grossi & Shirish Huprikar. 2019. Infectious Diseases in Solid-Organ Transplant Recipients. Infectious Diseases in Solid-Organ Transplant Recipients 145 163 .
Mario Tumbarello, Angela Raffaella Losito & Helen Giamarellou. (2018) Optimizing therapy in carbapenem-resistant Enterobacteriaceae infections. Current Opinion in Infectious Diseases 31:6, pages 566-577.
Crossref
Alessandra Oliva, Silvia Costantini, Massimiliano De Angelis, Stefania Garzoli, Mijat Božović, Maria Mascellino, Vincenzo Vullo & Rino Ragno. (2018) High Potency of Melaleuca alternifolia Essential Oil against Multi-Drug Resistant Gram-Negative Bacteria and Methicillin-Resistant Staphylococcus aureus. Molecules 23:10, pages 2584.
Crossref
Matthew E. Falagas, Tilemachos Skalidis, Konstantinos Z. Vardakas, Georgios L. Voulgaris, Georgios Papanikolaou & Nicholas Legakis. (2018) Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. International Journal of Antimicrobial Agents 52:2, pages 269-271.
Crossref
Jianhai Wei, Deyu Kong, Lei Wang, Yinyong Zhang, Wenhao Hu & Yushe Yang. (2018) Improved Synthesis of Yt-14, A Potent Antibiotic to Multidrug-Resistant Strains. Journal of Chemical Research 42:7, pages 354-360.
Crossref
Veronica Rico Caballero, Safa Almarzoky Abuhussain, Joseph L. Kuti & David P. Nicolau. (2018) Efficacy of Human-Simulated Exposures of Ceftolozane-Tazobactam Alone and in Combination with Amikacin or Colistin against Multidrug-Resistant Pseudomonas aeruginosa in an In Vitro Pharmacodynamic Model . Antimicrobial Agents and Chemotherapy 62:5.
Crossref
George G. Zhanel, Melanie R. Baxter, Heather J. Adam, Joyce Sutcliffe & James A. Karlowsky. (2018) In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014–2015. Diagnostic Microbiology and Infectious Disease 91:1, pages 55-62.
Crossref
Ronald Domalaon, Temilolu Idowu, George G. Zhanel & Frank Schweizer. (2018) Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?. Clinical Microbiology Reviews 31:2.
Crossref
Luzia Holfeld, Daniel Knappe & Ralf Hoffmann. (2018) Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 73:4, pages 933-941.
Crossref
Andreza Francisco Martins, Larissa Bail, Carmen Antonia Sanches Ito, Keite da Silva Nogueira, Tanise Vendruscolo Dalmolin, Amanda Silva Martins, Jaime Luis Lopes Rocha, Alisa W. Serio & Felipe Francisco Tuon. (2018) Antimicrobial activity of plazomicin against Enterobacteriaceae -producing carbapenemases from 50 Brazilian medical centers. Diagnostic Microbiology and Infectious Disease 90:3, pages 228-232.
Crossref
Nathaniel J. Rhodes, Caroline E. Cruce, J. Nicholas O’Donnell, Richard G. Wunderink & Alan R. Hauser. (2018) Resistance Trends and Treatment Options in Gram-Negative Ventilator-Associated Pneumonia. Current Infectious Disease Reports 20:2.
Crossref
C Croghan & D Lockington. (2017) Management of MRSA-positive eye swabs and the potential advantages of chloramphenicol availability in the United Kingdom. Eye 32:1, pages 157-159.
Crossref
Konstantinos Z Vardakas, Georgios L Voulgaris, Athanasios Maliaros, George Samonis & Matthew E Falagas. (2018) Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials. The Lancet Infectious Diseases 18:1, pages 108-120.
Crossref
Suprio R. Paul, Dilshad Qureshi, Yamini Yogalakshmi, Suraj K. Nayak, Vinay K. Singh, Irshaan Syed, Preetam Sarkar & Kunal Pal. (2018) Development of Bigels Based on Stearic Acid-Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications. Journal of Surfactants and Detergents 21:1, pages 17-29.
Crossref
Su Young Jung, Seung Hee Lee, Soo Young Lee, Seungwon Yang, Hayeon Noh, Eun Kyoung Chung & Jangik I. Lee. (2017) Antimicrobials for the treatment of drug-resistant Acinetobacter baumannii pneumonia in critically ill patients: a systemic review and Bayesian network meta-analysis. Critical Care 21:1.
Crossref
H. Wright, R.A. Bonomo & D.L. Paterson. (2017) New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?. Clinical Microbiology and Infection 23:10, pages 704-712.
Crossref
Matthew E. Falagas, Tilemachos Skalidis, Konstantinos Z. Vardakas & Nicholas J. Legakis. (2017) Activity of cefiderocol (S-649266) against carbapenem-resistant Gram-negative bacteria collected from inpatients in Greek hospitals. Journal of Antimicrobial Chemotherapy 72:6, pages 1704-1708.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.