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Expert Review of Anti-infective Therapy Volume 17, 2019 - Issue 1
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Drug Profile

Lefamulin: a promising new pleuromutilin antibiotic in the pipeline

Caroline DillonDivision of Pharmaceutical, Administrative and Social Sciences, Duquesne University School of Pharmacy, Pittsburgh, PA, USAView further author information
,
Anthony J. GuarascioDivision of Pharmaceutical, Administrative and Social Sciences, Duquesne University School of Pharmacy, Pittsburgh, PA, USA;Department of Pharmacy, Allegheny General Hospital, Pittsburgh, PA, USAView further author information
&
Jordan R. CovveyDivision of Pharmaceutical, Administrative and Social Sciences, Duquesne University School of Pharmacy, Pittsburgh, PA, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2913-2042View further author information
ORCID Icon
Pages 5-15 | Received 03 Oct 2018, Accepted 27 Nov 2018, Published online: 07 Dec 2018

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Shyam Sunder Tummanapalli & Mark DP Willcox. (2021) Antimicrobial resistance of ocular microbes and the role of antimicrobial peptides. Clinical and Experimental Optometry 104:3, pages 295-307.
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Zhe Zhang, Zhao-Sheng Zhang, Xiao Wang, Gao-Lei Xi, Zhen Jin & You-Zhi Tang. (2021) A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 2087-2103.
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Matteo Bassetti, Filippo Del Puente, Laura Magnasco & Daniele Roberto Giacobbe. (2020) Innovative therapies for acute bacterial skin and skin-structure infections (ABSSSI) caused by methicillin-resistant Staphylococcus aureus: advances in phase I and II trials. Expert Opinion on Investigational Drugs 29:5, pages 495-506.
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Vicenç Falcó, Joaquin Burgos & Benito Almirante. (2020) An overview of lefamulin for the treatment of community acquired bacterial pneumonia. Expert Opinion on Pharmacotherapy 21:6, pages 629-636.
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Articles from other publishers (14)

Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo & Nicolas Willand. (2023) Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance. European Journal of Medicinal Chemistry 256, pages 115413.
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芋丹 王. (2023) Progress in the Treatment of Mycoplasma genitalium Infection. Advances in Clinical Medicine 13:12, pages 18932-18940.
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Yu Deng, Yang Zhang, Xiao-Hu Chen & Cheng-Hong Li. (2023) Antibacterial activity evaluation of pleuromutilin derivatives with 4(3H)-quinazolinone scaffold against methicillin-resistant Staphylococcus aureus. European Journal of Medicinal Chemistry 246, pages 114960.
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Shubham Adhikary, Meher Kaur Duggal, Saraswathy Nagendran, Meena Chintamaneni, Hardeep Singh Tuli & Ginpreet Kaur. (2022) Lefamulin: a New Hope in the Field of Community-Acquired Bacterial Pneumonia. Current Pharmacology Reports 8:6, pages 418-426.
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Ravleen Kaur, Pooja Rani, Atanas G. Atanasov, Qushmua Alzahrani, Reena Gupta, Bhupinder Kapoor, Monica Gulati & Pooja Chawla. (2022) Discovery and Development of Antibacterial Agents: Fortuitous and Designed. Mini-Reviews in Medicinal Chemistry 22:7, pages 984-1029.
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Chaoyang Zhang, Lu Liu, Peng Zhang, Jingpo Cui, Xiaoxia Qin, Lichao Ma, Kun Han, Zhanhui Wang, Shaolin Wang, Shuangyang Ding & Zhangqi Shen. (2022) Characterization of a Novel Gene, srpA, Conferring Resistance to Streptogramin A, Pleuromutilins, and Lincosamides in Streptococcus suis. Engineering 9, pages 85-94.
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Mehdi Goudarzi, Amin Khoshbayan & Fateme Taheri. (2021) Retapamulin: Current Status and Future Perspectives. Archives of Clinical Infectious Diseases 16:4.
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Matthew William McCarthy. (2021) Clinical Pharmacokinetics and Pharmacodynamics of Lefamulin. Clinical Pharmacokinetics 60:11, pages 1387-1394.
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Robert M Taylor, James A Karlowsky, Melanie R Baxter, Heather J Adam, Andrew Walkty, Philippe Lagacé-Wiens & George G Zhanel. (2021) In vitro susceptibility of common bacterial pathogens causing respiratory tract infections in Canada to lefamulin, a new pleuromutilin. Official Journal of the Association of Medical Microbiology and Infectious Disease Canada 6:2, pages 149-162.
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Daniele R. Giacobbe, Laura Labate, Antonio Vena & Matteo Bassetti. (2021) Potential role of new-generation antibiotics in acute bacterial skin and skin structure infections. Current Opinion in Infectious Diseases 34:2, pages 109-117.
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George G. Zhanel, Christina Deng, Sheryl Zelenitsky, Courtney K. Lawrence, Heather J. Adam, Alyssa Golden, Liam Berry, Frank Schweizer, Michael A. Zhanel, Neal Irfan, Denice Bay, Philippe Lagacé-Wiens, Andrew Walkty, Lionel Mandell, Joseph P. LynchIIIIII & James A. Karlowsky. (2020) Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia. Drugs 81:2, pages 233-256.
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Qingxin Cui, Ruibin Bian, Fengbo Xu, Qingshan Li, Wenhu Wang & Qiang Bian. 2021. Bioactive Natural Products. Bioactive Natural Products 371 415 .
Li Zhang, Shi-qiao Zhao, Jie Zhang, Ying Sun, Ya-liu Xie, Yan-bin Liu, Cui-cui Ma, Bo-guang Jiang, Xue-yuan Liao, Wen-fang Li, Xing-jun Cheng & Zhen-ling Wang. (2020) Proteomic Analysis of Vesicle-Producing Pseudomonas aeruginosa PAO1 Exposed to X-Ray Irradiation. Frontiers in Microbiology 11.
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Thomas Lodise, Sam Colman, Daniel S Stein, David Fitts, Lisa Goldberg, Elizabeth Alexander, Patrick J Scoble & Jennifer Schranz. (2020) Post Hoc Assessment of Time to Clinical Response Among Adults Hospitalized with Community-Acquired Bacterial Pneumonia Who Received Either Lefamulin or Moxifloxacin in 2 Phase III Randomized, Double-Blind, Double-Dummy Clinical Trials. Open Forum Infectious Diseases 7:5.
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