6,352
Views
40
CrossRef citations to date
0
Altmetric
Editorial

The power of tears: how tear proteomics research could revolutionize the clinic

&
Pages 189-191 | Received 19 Dec 2016, Accepted 19 Jan 2017, Published online: 01 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Cecilia Chao, Lauren Lattery, Guoting Qin, Manasi Kamat, Kari Basso, Carol Lakkis, Mohamad Hasan & Kathryn Richdale. (2022) Tear Proteomics of Children and Young Adult Soft Contact Lens, Orthokeratology and Spectacle Wearers – A Pilot Study. Current Eye Research 47:6, pages 832-842.
Read now
Loïc Dayon, Ornella Cominetti & Michael Affolter. (2022) Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications. Expert Review of Proteomics 19:2, pages 131-151.
Read now

Articles from other publishers (38)

Snježana Kaštelan, Marijana Braš, Neda Pjevač, Ivana Bakija, Zora Tomić, Nada Pjevač Keleminić & Antonela Gverović Antunica. (2023) Tear Biomarkers and Alzheimer’s Disease. International Journal of Molecular Sciences 24:17, pages 13429.
Crossref
Vladimíra Tomečková, Soňa Tkáčiková, Ivan Talian, Gabriela Fabriciová, Andrej Hovan, Daria Kondrakhova, Katarína Zakutanská, Miriama Skirková, Vladimír Komanický & Natália Tomašovičová. (2023) Experimental Analysis of Tear Fluid and Its Processing for the Diagnosis of Multiple Sclerosis. Sensors 23:11, pages 5251.
Crossref
Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Obinna Sabastine Onugwu, Adaeze Chidiebere Echezona, Chinazom Precious Agbo, Stella Amarachi Ihim, Prosper Emeh, Petra Obioma Nnamani, Anthony Amaechi Attama & Vitaliy V. Khutoryanskiy. (2023) Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases. Journal of Controlled Release 354, pages 465-488.
Crossref
Marlies Gijs, Sinthuja Arumugam, Nienke van de Sande, Carroll A. B. Webers, Swaminathan Sethu, Arkasubhra Ghosh, Rohit Shetty, Jelle Vehof & Rudy M. M. A. Nuijts. (2023) Pre-analytical sample handling effects on tear fluid protein levels. Scientific Reports 13:1.
Crossref
Min Yang & Gui-Hua Xu. (2023) Isobaric tag for relative and absolute quantitation-based proteomics for investigating the effect of Guasha on lumbar disc herniation in rats . World Journal of Traditional Chinese Medicine 0:0, pages 0.
Crossref
Anna Daily, Prashanth Ravishankar, Wanyi Wang, Ryan Krone, Steve Harms & V. Suzanne Klimberg. (2022) Development and validation of a short-term breast health measure as a supplement to screening mammography. Biomarker Research 10:1.
Crossref
Mohammad Hadi Abbasian, Ali M. Ardekani, Navid Sobhani & Raheleh Roudi. (2022) The Role of Genomics and Proteomics in Lung Cancer Early Detection and Treatment. Cancers 14:20, pages 5144.
Crossref
Angelika Król-Grzymała, Edyta Sienkiewicz-Szłapka, Ewa Fiedorowicz, Dominika Rozmus, Anna Cieślińska & Andrzej Grzybowski. (2022) Tear Biomarkers in Alzheimer’s and Parkinson’s Diseases, and Multiple Sclerosis: Implications for Diagnosis (Systematic Review). International Journal of Molecular Sciences 23:17, pages 10123.
Crossref
Erika Ponzini, Carlo Santambrogio, Antonella De Palma, Pierluigi Mauri, Silvia Tavazzi & Rita Grandori. (2021) Mass spectrometry‐based tear proteomics for noninvasive biomarker discovery. Mass Spectrometry Reviews 41:5, pages 842-860.
Crossref
Gábor Kecskeméti, Edit Tóth-Molnár, Tamás Janáky & Zoltán Szabó. (2022) An Extensive Study of Phenol Red Thread as a Novel Non-Invasive Tear Sampling Technique for Proteomics Studies: Comparison with Two Commonly Used Methods. International Journal of Molecular Sciences 23:15, pages 8647.
Crossref
Wei Xiao, Jingqiao Chen, Huijing Ye, Xiaoyun Chen, Yuxiang Mao, Xian Ji, Shenglan Yang & Huasheng Yang. (2021) Tear cytokine profiles in patients with extranodal marginal zone B-cell lymphoma of the ocular adnexa. Eye 36:7, pages 1396-1402.
Crossref
Simin Masoudi. (2022) Biochemistry of human tear film: A review. Experimental Eye Research 220, pages 109101.
Crossref
Anna Daily, Prashanth Ravishankar, Steve Harms & V. Suzanne Klimberg. (2022) Using tears as a non-invasive source for early detection of breast cancer. PLOS ONE 17:4, pages e0267676.
Crossref
Haisheng Liu, Wenli Yuan, Qisheng Pang, Chengfeng Xue & Xiaomei Yan. (2022) Single-particle analysis of tear fluid reveals abundant presence of tissue factor-exposing extracellular vesicles with strong coagulation activity. Talanta 239, pages 123089.
Crossref
Julia Brunmair, Andrea Bileck, Doreen Schmidl, Gerhard Hagn, Samuel M. Meier-Menches, Nikolaus Hommer, Andreas Schlatter, Christopher Gerner & Gerhard Garhöfer. (2022) Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients. EPMA Journal 13:1, pages 107-123.
Crossref
Johannes Karl Fink. 2022. Contact Lenses. Contact Lenses 1 147 .
Hadi Khazaei, Danesh Khazaei, Rohan Verma, John Ng, Phillip A. Wilmarth, Larry L. David & James T. Rosenbaum. (2021) The potential of tear proteomics for diagnosis and management of orbital inflammatory disorders including Graves’ ophthalmopathy. Experimental Eye Research 213, pages 108813.
Crossref
Erika Ponzini, Diletta Ami, Alessandro Duse, Carlo Santambrogio, Antonella De Palma, Dario Di Silvestre, Pierluigi Mauri, Fabio Pezzoli, Antonino Natalello, Silvia Tavazzi & Rita Grandori. (2021) Single-Tear Proteomics: A Feasible Approach to Precision Medicine. International Journal of Molecular Sciences 22:19, pages 10750.
Crossref
Cem Simsek & Murat Dogru. (2021) Ocular Surface Biomarkers. Eye & Contact Lens: Science & Clinical Practice 47:5, pages 235-243.
Crossref
Lyndon Jones, Alex Hui, Chau-Minh Phan, Michael L. Read, Dimitri Azar, John Buch, Joseph B. Ciolino, Shehzad A. Naroo, Brian Pall, Kathleen Romond, Padmaja Sankaridurg, Cristina M. Schnider, Louise Terry & Mark Willcox. (2021) BCLA CLEAR – Contact lens technologies of the future. Contact Lens and Anterior Eye 44:2, pages 398-430.
Crossref
Lauren Page, Rachel A. Allbaugh, Jonathan P. Mochel, Jacqueline Peraza, Morgan Bertram & Lionel Sebbag. (2020) Impact of diurnal variation, sex, tear collection method, and disease state on tear protein levels in dogs. Veterinary Ophthalmology 23:6, pages 994-1000.
Crossref
Ting Zhang, Liang Hu, Huixiang Ma, Fangfang Ni, Fei Liu & Hao Chen. (2020) Detection of Tear Components Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry for Rapid Dry Eye Diagnosis. Journal of Proteome Research 19:9, pages 3644-3651.
Crossref
Ya-Nan Yao, Dandan Di, Zi-Cheng Yuan, Lin Wu & Bin Hu. (2020) Schirmer Paper Noninvasive Microsampling for Direct Mass Spectrometry Analysis of Human Tears. Analytical Chemistry 92:9, pages 6207-6212.
Crossref
Runzhong Fu, Wannita Klinngam, Martin Heur, Maria C. Edman & Sarah F. Hamm-Alvarez. (2020) Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease. Eye & Contact Lens: Science & Clinical Practice 46:2, pages S70-S83.
Crossref
Maria C Edman, Srikanth R Janga, Shruti Singh Kakan, Curtis T Okamoto, Daniel Freire, Danielle Feigenbaum, Mark Lew & Sarah F Hamm-Alvarez. (2020) Tears – more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease. Biomarkers in Medicine 14:2, pages 151-163.
Crossref
Anjali Takke & Pravin Shende. (2019) Non-invasive Biodiversified Sensors: A Modernized Screening Technology for Cancer. Current Pharmaceutical Design 25:38, pages 4108-4120.
Crossref
Sara I. Van Acker, Michel Haagdorens, Ella Roelant, Jos Rozema, Tine Possemiers, Veerle Van Gerwen, Marie-José Tassignon, Veva De Groot, Sorcha Ní Dhubhghaill, Carina Koppen & Nadia Zakaria. (2019) Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels. Mediators of Inflammation 2019, pages 1-11.
Crossref
Anamika Gangwar, Shikha Jain, Subhojit Paul, Yasmin Ahmad & Kalpana Bhargava. (2019) Biofluids in hypobaric hypoxia: best possible use, investigative strategies and putative markers. Journal of Proteins and Proteomics 10:3, pages 191-206.
Crossref
Lan Yu, Zhen Yang & Ming An. (2019) Lab on the eye: A review of tear-based wearable devices for medical use and health management. BioScience Trends 13:4, pages 308-313.
Crossref
Dingli Lu, Cuipei Lin, Xinwei Jiao, Zongming Song, Liya Wang, Jianqin Gu & Zhijie Li. (2019) Short-term High Fructose Intake Reprograms the Transcriptional Clock Rhythm of the Murine Extraorbital Lacrimal Gland. Investigative Opthalmology & Visual Science 60:6, pages 2038.
Crossref
Ming-Tse Kuo, Po-Chiung Fang, Tsai-Ling Chao, Alexander Chen, Yu-Hsuan Lai, Yu-Ting Huang & Chia-Yi Tseng. (2019) Tear Proteomics Approach to Monitoring Sjögren Syndrome or Dry Eye Disease. International Journal of Molecular Sciences 20:8, pages 1932.
Crossref
Rabab Sharif, Sashia Bak-Nielsen, Henrik Sejersen, Kai Ding, Jesper Hjortdal & Dimitrios Karamichos. (2019) Prolactin-Induced Protein is a novel biomarker for Keratoconus. Experimental Eye Research 179, pages 55-63.
Crossref
Éva Csősz, Noémi Tóth, Eszter Deák, Adrienne Csutak & József Tőzsér. (2018) Wound-Healing Markers Revealed by Proximity Extension Assay in Tears of Patients following Glaucoma Surgery. International Journal of Molecular Sciences 19:12, pages 4096.
Crossref
Ana Cláudia Raposo, Ricardo Dias Portela, Ali Masmali, Vinicius Cardoso‐Brito, Marcos Bernardo, Dayse Cury Oliveira & Arianne Pontes Oriá. (2018) Evaluation of lacrimal production, osmolarity, crystallization, proteomic profile, and biochemistry of capuchin monkeys’ tear film. Journal of Medical Primatology 47:6, pages 371-378.
Crossref
Gabriel Velez, Peter H. Tang, Thiago Cabral, Galaxy Y. Cho, Daniel A. Machlab, Stephen H. Tsang, Alexander G. Bassuk & Vinit B. Mahajan. (2018) Personalized Proteomics for Precision Health: Identifying Biomarkers of Vitreoretinal Disease. Translational Vision Science & Technology 7:5, pages 12.
Crossref
Ryan Tseng, Ching-Chuen Chen, Sheng-Min Hsu & Han-Sheng Chuang. (2018) Contact-Lens Biosensors. Sensors 18:8, pages 2651.
Crossref
Qilin Tang, Chao Zhang, Xiang Wu, Wenbin Duan, Weiji Weng, Junfeng Feng, Qing Mao, Shubin Chen, Jiyao Jiang & Guoyi Gao. (2018) Comprehensive Proteomic Profiling of Patients’ Tears Identifies Potential Biomarkers for the Traumatic Vegetative State. Neuroscience Bulletin 34:4, pages 626-638.
Crossref
Nadine Gerber-Hollbach, Kim Plattner, Olivia E. O'Leary, Paul Jenoe, Suzette Moes, Beatrice Drexler, Andreas Schoetzau, Jörg P. Halter & David Goldblum. (2018) Tear Film Proteomics Reveal Important Differences Between Patients With and Without Ocular GvHD After Allogeneic Hematopoietic Cell Transplantation. Investigative Opthalmology & Visual Science 59:8, pages 3521.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.