1,025
Views
74
CrossRef citations to date
0
Altmetric
Review

Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery

ORCID Icon, , & ORCID Icon
Pages 931-939 | Received 08 Aug 2017, Accepted 06 Sep 2017, Published online: 13 Sep 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Varun Dhiman, Deepak Pant, Tejpal Dhewa & Anita Padam. (2021) A Review on the Antidiabetic and Anticancer Activities of Conus Venom Peptides. Journal of Biologically Active Products from Nature 11:5-6, pages 413-441.
Read now
Taylor B. Smallwood & Richard J. Clark. (2021) Advances in venom peptide drug discovery: where are we at and where are we heading?. Expert Opinion on Drug Discovery 16:10, pages 1163-1173.
Read now
Robert A. Neff & Alan D. Wickenden. (2021) Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides. Channels 15:1, pages 193-207.
Read now

Articles from other publishers (71)

Aimee Coulter‐Parkhill, Neil Tanday, Diego Cobice, Christopher M. McLaughlin, Stephen McClean, Victor A. Gault & Nigel Irwin. (2023) Sustained metabolic benefits of ΔTRTX‐Ac1 , a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice . Diabetes, Obesity and Metabolism 26:1, pages 329-338.
Crossref
Yangyue Ni, Ruiyan Xiong, Yuxiao Zhu, Ning Luan, Chuanxin Yu, Kun Yang, Huiquan Wang, Xuejun Xu, Yuxuan Yang, Siyu Sun, Liyun Shi, Jon Rob Padde, Lin Chen, Lu Chen, Min Hou, Zhipeng Xu, Ren Lai & Minjun Ji. (2023) A target-based discovery from a parasitic helminth as a novel therapeutic approach for autoimmune diseases. eBioMedicine 95, pages 104751.
Crossref
Lia Costa, Emília Sousa & Carla Fernandes. (2023) Cyclic Peptides in Pipeline: What Future for These Great Molecules?. Pharmaceuticals 16:7, pages 996.
Crossref
Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R. Deuis, Rosanna Mary, Irina Vetter, David T. Wilson, Norelle L. Daly, Christina I. Schroeder, Emmanuel Bourinet & Sébastien Dutertre. (2023) Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa V 1.7 and hCa V 3 voltage‐gated channels . The FEBS Journal 290:14, pages 3688-3702.
Crossref
Thao N.T. Ho, A. Turner, Son H. Pham, Ha T. Nguyen, Linh T.T. Nguyen, Luan T. Nguyen & Tien T. Dang. (2023) Cysteine-rich peptides: From bioactivity to bioinsecticide applications. Toxicon 230, pages 107173.
Crossref
Samantha C. Salvage, Taufiq Rahman, David A. Eagles, Johanna S. Rees, Glenn F. King, Christopher L‐H. Huang & Antony P. Jackson. (2023) The β3‐subunit modulates the effect of venom peptides ProTx‐II and OD1 on Na V 1.7 gating . Journal of Cellular Physiology 238:6, pages 1354-1367.
Crossref
Tim Lüddecke, Anne Paas, Richard J. Harris, Lea Talmann, Kim N. Kirchhoff, André Billion, Kornelia Hardes, Antje Steinbrink, Doreen Gerlach, Bryan G. Fry & Andreas Vilcinskas. (2023) Venom biotechnology: casting light on nature’s deadliest weapons using synthetic biology. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Byungjo Lee, Min Kyoung Shin, Taegun Kim, Yu Jeong Shim, Jong Wha J. Joo, Jung-Suk Sung & Wonhee Jang. (2022) Prediction Models for Identifying Ion Channel-Modulating Peptides via Knowledge Transfer Approaches. IEEE Journal of Biomedical and Health Informatics 26:12, pages 6150-6160.
Crossref
Yanyan Chu, Huanhuan Zhang & Lei Zhang. (2022) Function Prediction of Peptide Toxins with Sequence-Based Multi-Tasking PU Learning Method. Toxins 14:11, pages 811.
Crossref
Muralidharan Vanuopadath, Dileepkumar Raveendran, Bipin Gopalakrishnan Nair & Sudarslal Sadasivan Nair. (2022) Venomics and antivenomics of Indian spectacled cobra (Naja naja) from the Western Ghats. Acta Tropica 228, pages 106324.
Crossref
Tim Lüddecke & Andreas Vilcinskas. (2021) Heilen mit Tiergiften. Chemie in unserer Zeit 56:2, pages 86-91.
Crossref
Sinem ÇALIMLI & Feride KOÇ. (2022) HAYVAN VENOMLARI VE İLAÇ TASARIMINDA KULLANIMLARIANIMAL VENOMS AND THEIR USE IN DRUG DESIGN. Sağlık Bilimleri Dergisi 31:1, pages 107-112.
Crossref
Bin TENG, Junfeng LI & Peigen REN. (2022) Peptide drugs application in metabolic diseases and discovery strategies. Journal of Holistic Integrative Pharmacy 3:1, pages 24-31.
Crossref
Mohsen Akbarian, Ali Khani, Sara Eghbalpour & Vladimir N. Uversky. (2022) Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action. International Journal of Molecular Sciences 23:3, pages 1445.
Crossref
Mangesh Mapari, Ritesh P. Bhole, Pramod B. Khedekar & Rupesh V. Chikhale. (2022) Challenges in targeting mycobacterial ATP synthase: The known and beyond. Journal of Molecular Structure 1247, pages 131331.
Crossref
Takahiro Shirozu, Nobuaki Seki, Akira Soga & Shinya Fukumoto. (2021) Evaluation of mosquitocidal efficacy of Scorpion Toxin Tf2 from <i>Tityus fasciolatus</i> against <i>Anopheles stephensi</i> mosquitoes<i>Tityus fasciolatus</i>サソリ毒素Tf2の殺ハマダラカ毒性の検証. Medical Entomology and Zoology 72:4, pages 255-259.
Crossref
Xiufen Wang, Qiwen Liao, Hanbin Chen, Guiyi Gong, Shirley Weng In Siu, Qian Chen, Hiotong Kam, Carolina Oi Lam Ung, Kwok-Kuen Cheung, Gandhi Rádis-Baptista, Clarence Tsun Ting Wong & Simon Ming-Yuen Lee. (2021) Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. Frontiers in Pharmacology 12.
Crossref
Samuel D. Robinson, Lucas Kambanis, Daniel Clayton, Hannes Hinneburg, Leo Corcilius, Alexander Mueller, Andrew A. Walker, Angelo Keramidas, Sameer S. Kulkarni, Alun Jones, Irina Vetter, Morten Thaysen-Andersen, Richard J. Payne, Glenn F. King & Eivind A.B. Undheim. (2021) A pain-causing and paralytic ant venom glycopeptide. iScience 24:10, pages 103175.
Crossref
Julien Giribaldi, Jennifer J. Smith & Christina I. Schroeder. (2021) Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells. Biotechnology Advances 50, pages 107769.
Crossref
Lucia Kuhn-Nentwig, Heidi E. L. Lischer, Stano Pekár, Nicolas Langenegger, Maria J. Albo, Marco Isaia & Wolfgang Nentwig. (2021) Linear Peptides—A Combinatorial Innovation in the Venom of Some Modern Spiders. Frontiers in Molecular Biosciences 8.
Crossref
Volker Herzig. (2021) Animal Venoms—Curse or Cure?. Biomedicines 9:4, pages 413.
Crossref
Markus Muttenthaler, Glenn F. King, David J. Adams & Paul F. Alewood. (2021) Trends in peptide drug discovery. Nature Reviews Drug Discovery 20:4, pages 309-325.
Crossref
Kristina Gopcevic, Ivanka Karadzic, Lidija Izrael-Zivkovic, Ana Medic, Aleksandra Isakovic, Marjan Popović, Dusan Kekic, Tatjana Stanojkovic, Amela Hozic & Mario Cindric. (2021) Study of the venom proteome of Vipera ammodytes ammodytes (Linnaeus, 1758): A qualitative overview, biochemical and biological profiling. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 37, pages 100776.
Crossref
Lucia Kuhn-Nentwig. (2021) Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes. Scientific Reports 11:1.
Crossref
Stephanie Mouchbahani-Constance & Reza Sharif-Naeini. (2021) Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms. Toxins 13:2, pages 154.
Crossref
Parisa Gazerani. (2021) Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?. Future Science OA 7:2.
Crossref
Vishal Musale, R. Charlotte Moffett, J. Michael Conlon, Peter R. Flatt & Yasser H. Abdel-Wahab. (2021) Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study. Peptides 136, pages 170472.
Crossref
Steve Peigneur, Cristina da Costa Oliveira, Flávia Cristina de Sousa Fonseca, Kirsten L. McMahon, Alexander Mueller, Olivier Cheneval, Ana Cristina Nogueira Freitas, Hana Starobova, Igor Dimitri Gama Duarte, David J. Craik, Irina Vetter, Maria Elena de Lima, Christina I. Schroeder & Jan Tytgat. (2021) Small cyclic sodium channel inhibitors. Biochemical Pharmacology 183, pages 114291.
Crossref
V. S. Gowri & V. Sabareesh. 2021. Integrated Omics Approaches to Infectious Diseases. Integrated Omics Approaches to Infectious Diseases 257 285 .
Linda Hernández Duran, Tasmin Lee Rymer & David Thomas Wilson. (2020) Variation in venom composition in the Australian funnel-web spiders Hadronyche valida. Toxicon: X 8, pages 100063.
Crossref
Samuel D. Robinson & Irina Vetter. (2020) Pharmacology and therapeutic potential of venom peptides. Biochemical Pharmacology 181, pages 114207.
Crossref
Danielle McCullough, Cristina Atofanei, Emily Knight, Steven A. Trim & Carol M. Trim. (2020) Kinome scale profiling of venom effects on cancer cells reveals potential new venom activities. Toxicon 185, pages 129-146.
Crossref
Zi-Lin Liu, Jing-Hao Hu, Fan Jiang & Yun-Dong Wu. (2020) CRiSP: accurate structure prediction of disulfide-rich peptides with cystine-specific sequence alignment and machine learning. Bioinformatics 36:11, pages 3385-3392.
Crossref
Gisela Jareth Lino-López, Laura Leticia Valdez-Velázquez, Gerardo Corzo, Maria Teresa Romero-Gutiérrez, Juana María Jiménez-Vargas, Armando Rodríguez-Vázquez, Oscar F. Vazquez-Vuelvas & Gabino Gonzalez-Carrillo. (2020) Venom gland transcriptome from Heloderma horridum horridum by high-throughput sequencing. Toxicon 180, pages 62-78.
Crossref
Samira R. Aili, Axel Touchard, Regan Hayward, Samuel D. Robinson, Sandy S. Pineda, Hadrien Lalagüe, Mrinalini, Irina Vetter, Eivind A. B. Undheim, R. Manjunatha Kini, Pierre Escoubas, Matthew P. Padula, Garry S. A. Myers & Graham M. Nicholson. (2020) An Integrated Proteomic and Transcriptomic Analysis Reveals the Venom Complexity of the Bullet Ant Paraponera clavata. Toxins 12:5, pages 324.
Crossref
YanYan Chu, PeiJu Qiu & RiLei Yu. (2020) Centipede Venom Peptides Acting on Ion Channels. Toxins 12:4, pages 230.
Crossref
Aiqin Zhu, Aerziguli Aierken, Zhihao Yao, Simon Vu, Yuhua Tian, Jie Zheng, Shilong Yang & Fan Yang. (2020) A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel. Toxicon 178, pages 41-49.
Crossref
Katia Conceição, Gabrielle L. de Cena, Verônica A. da Silva, Xisto Antonio de Oliveira Neto, Vitor Martins de Andrade, Dayane Batista Tada, Michael Richardson, Sonia A. de Andrade, Susana A. Dias, Miguel A. R. B. Castanho & Mônica Lopes-Ferreira. (2020) Design of bioactive peptides derived from CART sequence isolated from the toadfish Thalassophryne nattereri. 3 Biotech 10:4.
Crossref
Dharmeshkumar Patel, Serdar Kuyucak & Craig A. Doupnik. (2020) Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels. Biochemistry 59:7, pages 836-850.
Crossref
Ana P. dos Santos, Tamara G. de Araújo & Gandhi Rádis-Baptista. (2020) Nanoparticles Functionalized with Venom-Derived Peptides and Toxins for Pharmaceutical Applications. Current Pharmaceutical Biotechnology 21:2, pages 97-109.
Crossref
Rongjun He, Jia Pan, John P. Mayer & Fa Liu. (2020) The Chemical Methods of Disulfide Bond Formation and Their Applications to Drug Conjugates. Current Organic Chemistry 23:25, pages 2802-2821.
Crossref
Lays Fernanda Nunes Dourado, Flavia Rodrigues da Silva, Cibele Rodrigues Toledo, Carolina Nunes da Silva, Cleildo Pereira Santana, Bruna Lopes da Costa, Maria Elena de Lima & Armando da Silva Cunha Junior. (2020) Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage. Journal of Venomous Animals and Toxins including Tropical Diseases 26.
Crossref
Robert A. Neff, Mack Flinspach, Alan Gibbs, Amy Y. Shih, Natali A. Minassian, Yi Liu, Ross Fellows, Ondrej Libiger, Stephanie Young, Michael W. Pennington, Michael J. Hunter & Alan D. Wickenden. (2020) Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7. Journal of Biological Chemistry 295:5, pages 1315-1327.
Crossref
. 2020. Biological Chirality. Biological Chirality 137 248 .
Hamed Memariani, Mojtaba Memariani, Hamideh Moravvej & Mohammad Shahidi-Dadras. (2019) Melittin: a venom-derived peptide with promising anti-viral properties. European Journal of Clinical Microbiology & Infectious Diseases 39:1, pages 5-17.
Crossref
Ondrej Šedo, Stano Pekár & Zbyněk Zdráhal. 2020. Snake and Spider Toxins. Snake and Spider Toxins 173 181 .
Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis & Paul F. Alewood. (2019) Conotoxins: Chemistry and Biology. Chemical Reviews 119:21, pages 11510-11549.
Crossref
Rakesh Narang, Raj Kumar, Sourav Kalra, Surendra Kumar Nayak, Gopal L. Khatik, Gadekula Naresh Kumar, Kalvatala Sudhakar & Sachin Kumar Singh. (2019) Recent advancements in mechanistic studies and structure activity relationship of FoF1 ATP synthase inhibitor as antimicrobial agent. European Journal of Medicinal Chemistry 182, pages 111644.
Crossref
Sabah Ul-Hasan, Eduardo Rodríguez-Román, Adam M. Reitzel, Rachelle M.M. Adams, Volker Herzig, Clarissa J. Nobile, Anthony J. Saviola, Steven A. Trim, Erin E. Stiers, Sterghios A. Moschos, Carl N. Keiser, Daniel Petras, Yehu Moran & Timothy J. Colston. (2019) The emerging field of venom-microbiomics for exploring venom as a microenvironment, and the corresponding Initiative for Venom Associated Microbes and Parasites (iVAMP). Toxicon: X 4, pages 100016.
Crossref
Orsolya Péterfi, Francisc Boda, Zoltán Szabó, Elek Ferencz & László Bába. (2019) Hypotensive Snake Venom Components—A Mini-Review. Molecules 24:15, pages 2778.
Crossref
A.T.A. Sachetto & N. Mackman. (2019) Modulation of the mammalian coagulation system by venoms and other proteins from snakes, arthropods, nematodes and insects. Thrombosis Research 178, pages 145-154.
Crossref
Qiwen Liao, Guiyi Gong, Terence C. W. Poon, Irene L. Ang, Kate M. K. Lei, Shirley Weng In Siu, Clarence Tsun Ting Wong, Gandhi Rádis-Baptista & Simon Ming-Yuen Lee. (2019) Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia). Archives of Toxicology 93:6, pages 1745-1767.
Crossref
Lau D. Nielsen, Mads M. Foged, Anastasia Albert, Andreas B. Bertelsen, Cecilie L. Søltoft, Samuel D. Robinson, Steen V. Petersen, Anthony W. Purcell, Baldomero M. Olivera, Raymond S. Norton, Terje Vasskog, Helena Safavi-Hemami, Kaare Teilum & Lars Ellgaard. (2019) The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework. Journal of Biological Chemistry 294:22, pages 8745-8759.
Crossref
Heike Wulff, Palle Christophersen, Paul Colussi, K. George Chandy & Vladimir Yarov-Yarovoy. (2019) Antibodies and venom peptides: new modalities for ion channels. Nature Reviews Drug Discovery 18:5, pages 339-357.
Crossref
Graeme C. Clark, Nicholas R. Casewell, Christopher T. Elliott, Alan L. Harvey, Andrew G. Jamieson, Peter N. Strong & Andrew D. Turner. (2019) Friends or Foes? Emerging Impacts of Biological Toxins. Trends in Biochemical Sciences 44:4, pages 365-379.
Crossref
Peng Lyu & Hang F. Kwok. (2019) High-throughput Strategy Accelerates the Progress of Marine Anticancer Peptide Drug Development. Recent Patents on Anti-Cancer Drug Discovery 14:1, pages 2-4.
Crossref
Jean-Étienne R.L. Morlighem & Gandhi Radis-Baptista. (2019) The Place for Enzymes and Biologically Active Peptides from Marine Organisms for Application in Industrial and Pharmaceutical Biotechnology. Current Protein & Peptide Science 20:4, pages 334-355.
Crossref
Volker Herzig. (2019) Arthropod assassins: Crawling biochemists with diverse toxin pharmacopeias. Toxicon 158, pages 33-37.
Crossref
Volker Herzig, Glenn F. King & Eivind A.B. Undheim. (2019) Can we resolve the taxonomic bias in spider venom research?. Toxicon: X 1, pages 100005.
Crossref
Saak V. Ovsepian, Valerie B. O’Leary, Naira M. Ayvazyan, Ahmed Al-Sabi, Vasilis Ntziachristos & James O. Dolly. (2019) Neurobiology and therapeutic applications of neurotoxins targeting transmitter release. Pharmacology & Therapeutics 193, pages 135-155.
Crossref
Helena Safavi-Hemami, Shane E. Brogan & Baldomero M. Olivera. (2019) Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways. Journal of Proteomics 190, pages 12-20.
Crossref
Yoan Duhoo, Ana Filipa Sequeira, Natalie J. Saez, Jeremy Turchetto, Laurie Ramond, Fanny Peysson, Joana L. A. Brás, Nicolas Gilles, Hervé Darbon, Carlos M. G. A. Fontes & Renaud Vincentelli. 2019. High-Throughput Protein Production and Purification. High-Throughput Protein Production and Purification 165 190 .
H. Starobova, Himaya S. W. A., R. J. Lewis & I. Vetter. (2018) Transcriptomics in pain research: insights from new and old technologies. Molecular Omics 14:6, pages 389-404.
Crossref
Qing Li, Maren Watkins, Samuel Robinson, Helena Safavi-Hemami & Mark Yandell. (2018) Discovery of Novel Conotoxin Candidates Using Machine Learning. Toxins 10:12, pages 503.
Crossref
Matthew D. King, Thomas Long, Daniel L. Pfalmer, Timothy L. Andersen & Owen M. McDougal. (2018) SPIDR: small-molecule peptide-influenced drug repurposing. BMC Bioinformatics 19:1.
Crossref
Andrew Walker, James Dobson, Jiayi Jin, Samuel Robinson, Volker Herzig, Irina Vetter, Glenn King & Bryan Fry. (2018) Buzz Kill: Function and Proteomic Composition of Venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae). Toxins 10:11, pages 456.
Crossref
Samuel D. Robinson, Alexander Mueller, Daniel ClaytonHana Starobova, Brett R. HamiltonRichard J. Payne, Irina VetterGlenn F. King & Eivind A. B. Undheim. (2018) A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa , reveals a hyperdiverse hymenopteran toxin gene family . Science Advances 4:9.
Crossref
E. Bäckryd. (2018) Do the potential benefits outweigh the risks? An update on the use of ziconotide in clinical practice. European Journal of Pain 22:7, pages 1193-1202.
Crossref
Mathilde R. Israel, Michael Morgan, Bryan Tay & Jennifer R. Deuis. (2018) Toxins as tools: Fingerprinting neuronal pharmacology. Neuroscience Letters 679, pages 4-14.
Crossref
Jennifer Smith & Eivind Undheim. (2018) True Lies: Using Proteomics to Assess the Accuracy of Transcriptome-Based Venomics in Centipedes Uncovers False Positives and Reveals Startling Intraspecific Variation in Scolopendra subspinipes. Toxins 10:3, pages 96.
Crossref
Krzysztof Kowalski, Paweł Marciniak, Grzegorz Rosiński & Leszek Rychlik. (2018) Toxic activity and protein identification from the parotoid gland secretion of the common toad Bufo bufo. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 205, pages 43-52.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.