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International Journal of Audiology Volume 43, 2004 - Issue 3
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Original Article

α-Tocopherol protective effects on gentamicin ototoxicity: an experimental study

Efectos protectores del α-Tocoferol en la toxicidad por gentamicina: un estudio experimental

Anna Rita Fetoni Institute of Otolaryngology, Catholic University of Rome, Rome, Italy
,
Bruno Sergi Institute of Human Physiology, Catholic University of Rome, Rome, Italy
,
Aldo Ferraresi Institute of Otolaryngology, Catholic University of Rome, Rome, Italy
,
Gaetano Paludetti Institute of Human Physiology, Catholic University of Rome, Rome, Italy
&
Diana Troiani Institute of Otolaryngology, Catholic University of Rome, Rome, Italy
Pages 166-171 | Received 10 Jul 2002, Accepted 13 Mar 2003, Published online: 07 Jul 2009

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Hossein Heli, Siamak Mirtorabi & Khashayar Karimian. (2011) Advances in iron chelation: an update. Expert Opinion on Therapeutic Patents 21:6, pages 819-856.
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Anna Rita Fetoni, Sara Eramo, Diana Troiani & Gaetano Paludetti. (2011) Therapeutic window for ferulic acid protection against noise-induced hearing loss in the guinea pig. Acta Oto-Laryngologica 131:4, pages 419-427.
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Ghada Al-Malky, Ranjan Suri, Sally J. Dawson, Tony Sirimanna & David Kemp. (2011) Aminoglycoside antibiotics cochleotoxicity in paediatric cystic fibrosis (CF) patients: A study using extended high-frequency audiometry and distortion product otoacoustic emissions. International Journal of Audiology 50:2, pages 112-122.
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Anna R. Fetoni, Massimo Ralli, Bruno Sergi, Claudio Parrilla, Diana Troiani & Gaetano Paludetti. (2008) Protective properties of antioxidant drugs in noise-induced hearing loss in the guinea pig. Audiological Medicine 6:4, pages 271-277.
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Articles from other publishers (29)

A. A. Solokha, N. V. Stavitskaya, Ya. Sh. Shvarts, S. V. Sklyuev & N. V. Tursunova. (2023) Current Methods of Prevention of Aminoglycoside Ototoxicity in Patients with Pulmonary Tuberculosis. Tuberculosis and Lung Diseases 101:3, pages 87-93.
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Jia-Ni Lin, Jen-Shu Wang, Chung-Ching Lin, Hui-Yi Lin, Szu-Hui Yu, Yu-Hsuan Wen, Guo-Fang Tseng, Chuan-Jen Hsu & Hung-Pin Wu. (2022) Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells. Journal of the Chinese Medical Association 85:5, pages 617-626.
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Kadar N. Prasad & Stephen C. Bondy. (2020) Increased oxidative stress, inflammation, and glutamate: Potential preventive and therapeutic targets for hearing disorders. Mechanisms of Ageing and Development 185, pages 111191.
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Chaitanya Mamillapalli, Asmita Dhukhwa, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak & Vickram Ramkumar. 2020. New Therapies to Prevent or Cure Auditory Disorders. New Therapies to Prevent or Cure Auditory Disorders 51 87 .
Gaëlle Naert, Marie-Pierre Pasdelou & Colleen G. Le Prell. (2019) Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise. The Journal of the Acoustical Society of America 146:5, pages 3743-3769.
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Hyejeong Hong, Kelly E. Dooley, Laura E. Starbird, Howard W. Francis & Jason E. Farley. (2019) Adverse outcome pathway for aminoglycoside ototoxicity in drug-resistant tuberculosis treatment. Archives of Toxicology 93:5, pages 1385-1399.
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Shin Hye Kim, Gaon Jung, Sangjae Kim & Ja-Won Koo. (2018) Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice. Frontiers in Cellular Neuroscience 12.
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Carolyn O. Dirain, Maria Raye Ann V. Ng, Bailey Milne-Davies, Jerin K. Joseph & Patrick J. Antonelli. (2018) Evaluation of Mitoquinone for Protecting Against Amikacin-Induced Ototoxicity in Guinea Pigs. Otology & Neurotology 39:1, pages 111-118.
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Channy Park, Hye-Min Ji, Se-Jin Kim, Sung-Hee Kil, Joon No Lee, Seongae Kwak, Seong-Kyu Choe & Raekil Park. (2017) Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes. International Journal of Molecular Medicine 39:4, pages 960-968.
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Felice Scasso, Andrea Elio Sprio, Luciano Canobbio, Chiara Scanarotti, Giorgio Manini, Giovanni Nicolao Berta & Anna Maria Bassi. (2017) Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study. Heliyon 3:2, pages e00251.
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Channy Park, Se-Jin Kim, Won Kyo Lee, Sung Kyun Moon, SeongAe Kwak, Seong-Kyu Choe & Raekil Park. (2016) Tetrabromobisphenol-A induces apoptotic death of auditory cells and hearing loss. Biochemical and Biophysical Research Communications 478:4, pages 1667-1673.
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Colleen G. Le Prell & Josef M. Miller. 2016. Oxidative Stress and Antioxidant Protection. Oxidative Stress and Antioxidant Protection 115 132 .
Kari L. Green, Donald L. Swiderski, Diane M. Prieskorn, Susan J. DeRemer, Lisa A. Beyer, Josef M. Miller, Glenn E. Green & Yehoash Raphael. (2016) ACEMg Diet Supplement Modifies Progression of Hereditary Deafness. Scientific Reports 6:1.
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Maria Raye Anne V. Ng, Patrick J. Antonelli, Jerin Joseph & Carolyn Ojano Dirain. (2014) Assessment of Mitochondrial Membrane Potential in HEI‐OC1 and LLC‐PK1 Cells Treated with Gentamicin and Mitoquinone. Otolaryngology–Head and Neck Surgery 152:4, pages 729-733.
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Leonard P. Rybak & Michael J. Brenner. 2015. Free Radicals in ENT Pathology. Free Radicals in ENT Pathology 195 216 .
Meiyan Jiang, Qi Wang, Takatoshi Karasawa, Ja-Won Koo, Hongzhe Li & Peter S. Steyger. (2014) Sodium-Glucose Transporter-2 (SGLT2; SLC5A2) Enhances Cellular Uptake of Aminoglycosides. PLoS ONE 9:9, pages e108941.
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C. G. Le Prell, C. Ojano-Dirain, E. W. Rudnick, M. A. Nelson, S. J. DeRemer, D. M. Prieskorn & J. M. Miller. (2014) Assessment of Nutrient Supplement to Reduce Gentamicin-Induced Ototoxicity. Journal of the Association for Research in Otolaryngology.
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Hongzhuo Liu, Jinsong Hao & Kevin S. Li. (2013) Current strategies for drug delivery to the inner ear. Acta Pharmaceutica Sinica B 3:2, pages 86-96.
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Carolyn P. Ojano‐Dirain & Patrick J. Antonelli. (2012) Prevention of gentamicin‐induced apoptosis with the mitochondria‐targeted antioxidant mitoquinone. The Laryngoscope 122:11, pages 2543-2548.
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Ting Hua Yang, Yi Ho Young & Shing Hwa Liu. (2011) EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis. The Journal of Nutritional Biochemistry 22:9, pages 886-894.
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M. E. Huth, A. J. Ricci & A. G. Cheng. (2011) Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection. International Journal of Otolaryngology 2011, pages 1-19.
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A.R. Fetoni, C. Mancuso, S.L.M. Eramo, M. Ralli, R. Piacentini, E. Barone, G. Paludetti & D. Troiani. (2010) In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig. Neuroscience 169:4, pages 1575-1588.
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S Murillo-Cuesta, J Contreras, R Cediel & I Varela-Nieto. (2010) Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Laboratory Animals 44:2, pages 124-131.
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A.L. Poirrier, P. Van den Ackerveken, T.S. Kim, R. Vandenbosch, L. Nguyen, P.P. Lefebvre & B. Malgrange. (2010) Ototoxic drugs: Difference in sensitivity between mice and guinea pigs. Toxicology Letters 193:1, pages 41-49.
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Y.H. Choung, A. Taura, K. Pak, S.J. Choi, M. Masuda & A.F. Ryan. (2009) Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of corti treated with gentamicin. Neuroscience 161:1, pages 214-226.
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Wojciech Szczepanik, Artur Krężel, Magdalena Brzezowska, Ewa Dworniczek & Małgorzata Jeżowska-Bojczuk. (2008) Impact of Cu(II) ions on the structure and antimicrobial properties of sisomicin, an aminoglycoside antibiotic. Inorganica Chimica Acta 361:9-10, pages 2659-2666.
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Anna R. Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini & Diana Troiani. (2008) Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E. NeuroReport 19:3, pages 277-281.
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Adolfo M Bronstein. (2005) Oscillopsia: editorial review. Current Opinion in Neurology 18:1, pages 1-3.
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D. Yamashita, H.-Y. Jiang, C.G. Le Prell, J. Schacht & J.M. Miller. (2005) Post-exposure treatment attenuates noise-induced hearing loss. Neuroscience 134:2, pages 633-642.
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