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Nucleosides, Nucleotides & Nucleic Acids Volume 30, 2011 - Issue 12
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Original Articles

Human Uric Acid Transporter 1 (hURAT1): An Inhibitor Structure–Activity Relationship (SAR) Study

M. F. Wempe School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
,
B. Quade School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
,
P. Jutabha Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
,
T. Iwen School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
,
M. Frick School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
,
P. J. Rice School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
,
S. Wakui Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
&
H. Endou Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; J-Pharma Co., Ltd., Shinjuku, Shinjuku-ku, Tokyo, Japan
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Pages 1312-1323 | Received 17 Apr 2011, Accepted 31 May 2011, Published online: 01 Dec 2011

Citations (6)

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Read on this site (2)

Ying Pan & Ling-Dong Kong. (2016) Urate transporter URAT1 inhibitors: a patent review (2012 - 2015). Expert Opinion on Therapeutic Patents 26:10, pages 1129-1138.
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Michael F Wempe, Janet W Lightner, Bettina Miller, Timothy J Iwen, Peter J Rice, Shin Wakui, Naohiko Anzai, Promsuk Jutabha & Hitoshi Endou. (2012) Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies. Drug Design, Development and Therapy 6, pages 323-339.
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Articles from other publishers (4)

Qianghua Yuan, Yuan Cheng, Rong Sheng, Yan Yuan & Mei Hu. (2022) A Brief Review of Natural Products with Urate Transporter 1 Inhibition for the Treatment of Hyperuricemia. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-16.
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Tingting Zhao, Zean Zhao, Fengting Lu, Shan Chang, Jiajie Zhang, Jianxin Pang & Yuanxin Tian. (2019) Two- and three-dimensional QSAR studies on hURAT1 inhibitors with flexible linkers: topomer CoMFA and HQSAR. Molecular Diversity 24:1, pages 141-154.
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Tianqiao Yong, Yizhen Xie, Shaodan Chen, Diling Chen, Jiyan Su, Chunwei Jiao, Huiping Hu & Chun Xiao. (2018) Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling. Journal of Functional Foods 40, pages 582-588.
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Xintuo Yang, Xuehai Pang, Lei Fan, Xinghai Li & Yuanwei Chen. (2017) Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors. Bioorganic & Medicinal Chemistry Letters 27:9, pages 1919-1922.
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