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Nucleosides, Nucleotides & Nucleic Acids Volume 34, 2015 - Issue 10
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Original Articles

Novel Nucleoside Analogues: First Synthesis of Pyridine-4-Thioglycosides and Their Cytotoxic Evaluation

Galal ElgemeieChemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, EgyptCorrespondence[email protected]
,
Mamdouh Abou-ZeidGreen Chemistry Department, National Research Center, Dokki, Cairo, Egypt
,
Shahinaz AlsaidChemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt
,
Ali HebishyChemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt
&
Hanaa EssaChemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt
Pages 659-673 | Received 01 Aug 2014, Accepted 27 Jun 2015, Published online: 13 Oct 2015

Citations (33)

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Ashraf M. Mohamed, Mohamed N. El-Bayaa, Dina H. Elnaggar, Naglaa A. Abdel-Hafez, Salwa F. Mohamed, Mohamed A. Elsayed, Eman S. Abou-Amra, Mervat M. Omran & Wael A. El-Sayed. (2023) Novel [1,2,3]triazoles, [1,2,3]triazolo[4,5-d]Pyrimidines, and Some of Their Glycoside Derivatives: Synthesis and Molecular Modeling as Potential Apoptotic Antitumor Agents. Polycyclic Aromatic Compounds 0:0, pages 1-25.
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Mamdouh A. Abu-Zaied, Galal H. Elgemeie, Fathi T. Halaweish & Sherif F. Hammad. (2022) Synthesis of novel pyridine and pyrimidine thioglycoside phosphoramidates for the treatment of COVID-19 and influenza A viruses. Nucleosides, Nucleotides & Nucleic Acids 41:9, pages 851-877.
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Mamdouh A. Abu-Zaied, Galal H. Elgemeie & Nashwa M. Mahmoud. (2021) Synthesis of novel pyrimidine thioglycosides as structural analogs of favipiravir (avigan) and their antibird flu virus activity. Nucleosides, Nucleotides & Nucleic Acids 40:3, pages 336-356.
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Galal H. Elgemeie, Mamdouh A. Abu-Zaied & Abdel-Tawab H. Mossa. (2019) Novel Synthesis and Biological Evaluation of the First Pyrazole Thioglycosides as Pyrazofurin Analogues. Nucleosides, Nucleotides & Nucleic Acids 38:3, pages 183-202.
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Galal H. Elgemeie, Sheikha A. Alkhursani & Reham A. Mohamed. (2019) New synthetic strategies for acyclic and cyclic pyrimidinethione nucleosides and their analogues. Nucleosides, Nucleotides & Nucleic Acids 38:1, pages 12-87.
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Galal H. Elgemeie & Reham A. Mohamed. (2019) Microwave chemistry: Synthesis of purine and pyrimidine nucleosides using microwave radiation. Journal of Carbohydrate Chemistry 38:1, pages 20-66.
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Galal H. Elgemeie & Dina H. El-Naggar. (2018) Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents. Nucleosides, Nucleotides & Nucleic Acids 37:4, pages 199-216.
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Galal H. Elgemeie, Nahed M. Fathy, Ayman B. Farag & Sheikha A. Alkhursani. (2018) Design, synthesis, molecular docking and anti-hepatocellular carcinoma evaluation of novel acyclic pyridine thioglycosides. Nucleosides, Nucleotides & Nucleic Acids 37:3, pages 186-198.
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Galal H. Elgemeie, Mamdouh A. Abu-Zaied & Galal A. Nawwar. (2018) First novel synthesis of triazole thioglycosides as ribavirin analogues. Nucleosides, Nucleotides & Nucleic Acids 37:2, pages 112-123.
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Mamdouh A. Abu-Zaied & Galal H. Elgemeie. (2018) A facile synthesis of novel pyrazolopyrimidine thioglycosides as purine thioglycoside analogues. Nucleosides, Nucleotides & Nucleic Acids 37:1, pages 67-77.
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Mamdouh A. Abu-Zaied & Galal H. Elgemeie. (2017) Synthesis of the first novel pyrazole thioglycosides as deaza ribavirin analogues. Nucleosides, Nucleotides & Nucleic Acids 36:12, pages 713-725.
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Galal H. Elgemeie & Mamdouh A. Abu-Zaied. (2017) Heterocyclic thioglycosides in carbohydrate research: Synthesis of thiophene thioglycosides. Nucleosides, Nucleotides & Nucleic Acids 36:8, pages 511-519.
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Galal H. Elgemeie, Nahed M. Fathy, Ayman B. Farag & Sheikha A. Alkursani. (2017) Antimetabolites: Design, synthesis, and cytotoxic evaluation of novel dihydropyridine thioglycosides and pyridine thioglycosides. Nucleosides, Nucleotides & Nucleic Acids 36:5, pages 355-377.
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Galal H. Elgemeie, Ali M. Salah, Nermeen S. Abbas, Hoda A. Hussein & Reham A. Mohamed. (2017) Pyrimidine non-nucleoside analogs: A direct synthesis of a novel class of N-substituted amino and N-sulfonamide derivatives of pyrimidines. Nucleosides, Nucleotides & Nucleic Acids 36:3, pages 213-223.
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Galal Elgemeie, Nahed Fathy, Wafaa Zaghary & Ayman Farag. (2017) S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives. Nucleosides, Nucleotides & Nucleic Acids 36:3, pages 198-212.
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Galal Elgemeie, Mamdouh Abu-Zaied, Ali Hebishy, Nermen Abbas & Mai Hamed. (2016) A First Microwave-Assisted Synthesis of a New Class of Purine and Guanine Thioglycoside Analogs. Nucleosides, Nucleotides & Nucleic Acids 35:9, pages 459-478.
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Articles from other publishers (17)

Atukuri Dorababu. (2022) Pyrazolopyrimidines as attractive pharmacophores in efficient drug design: A recent update. Archiv der Pharmazie 355:10.
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Dorababu Atukuri. (2022) Pyrazolopyridine: An efficient pharmacophore in recent drug design and development. Chemical Biology & Drug Design 100:3, pages 376-388.
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Rasha A. Azzam, Galal H. Elgemeie, Nagwa M. Gad & Peter G. Jones. (2022) 4-Amino-5-(4-bromobenzoyl)-3-(benzo[ d ]thiazol-2-yl)-2-[(2′,3′,4′,6′-tetra- O -acetyl-β- D -galactopyranosyl)sulfanyl]thiophene . IUCrData 7:4.
Crossref
Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 303 392 .
Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 547 611 .
Mamdouh A. Abu-Zaied, Galal H. Elgemeie & Nashwa M. Mahmoud. (2021) Anti-Covid-19 Drug Analogues: Synthesis of Novel Pyrimidine Thioglycosides as Antiviral Agents Against SARS-COV-2 and Avian Influenza H5N1 Viruses. ACS Omega 6:26, pages 16890-16904.
Crossref
Mamdouh A. Abu-Zaied, Nashwa M. Mahmoud & Galal H. Elgemeie. (2020) Toward Developing Therapies against Corona Virus: Synthesis and Anti-Avian Influenza Virus Activity of Novel Cytosine Thioglycoside Analogues. ACS Omega 5:32, pages 20042-20050.
Crossref
Mamdouh A. Abu-Zaied, Galal H. Elgemeie & Peter G. Jones. (2019) Crystal structure of 4,6-dimethyl-2-[(2,3,4,6-tetra- O -acetyl-β- D -galactopyranosyl)sulfanyl]pyrimidine . Acta Crystallographica Section E Crystallographic Communications 75:12, pages 1820-1823.
Crossref
Ali M. Hebishy, Galal H. Elgemeie, Hagar T. Salama & Peter G. Jones. (2019) 3-Ethoxy-5-phenyl-1 H -1,2,4-triazole . IUCrData 4:4.
Crossref
Rasha A. Azzam, Galal H. Elgemeie, Rokia R. Osman & Peter G. Jones. (2019) Crystal structure of potassium [4-amino-5-(benzo[ d ]thiazol-2-yl)-6-(methylsulfanyl)pyrimidin-2-yl](phenylsulfonyl)azanide dimethylformamide monosolvate hemihydrate . Acta Crystallographica Section E Crystallographic Communications 75:3, pages 367-371.
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Sherif F. Hammad, Doaa M. Masoud, Galal H. Elgemeie & Peter G. Jones. (2018) Crystal structure of racemic 2-[(β-arabinopyranosyl)sulfanyl]-4,6-diphenylpyridine-3-carbonitrile. Acta Crystallographica Section E Crystallographic Communications 74:6, pages 853-856.
Crossref
Rasha A. Azzam, Galal H. Elgemeie, Rasha E. Elsayed & Peter G. Jones. (2017) Crystal structure of N -[6-amino-5-(benzo[ d ]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate . Acta Crystallographica Section E Crystallographic Communications 73:12, pages 1820-1822.
Crossref
Doaa M. Masoud, Sherif F. Hammad, Galal H. Elgemeie & Peter G. Jones. (2017) Crystal structure of 4,6-dimethyl-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2 H -pyran-2-yl]sulfanyl}nicotinonitrile . Acta Crystallographica Section E Crystallographic Communications 73:11, pages 1751-1754.
Crossref
Galal H. Elgemeie, Mamdouh A. Abu-Zaied & Samah A. Loutfy. (2017) 4-Aminoantipyrine in carbohydrate research: Design, synthesis and anticancer activity of thioglycosides of a novel class of 4-aminoantipyrines and their corresponding pyrazolopyrimidine and pyrazolopyridine thioglycosides. Tetrahedron 73:40, pages 5853-5861.
Crossref
Rasha A. Azzam, Galal H. Elgemeie, Rokia Ramadan & Peter G. Jones. (2017) Crystal structure of 2-cyano-3,3-bis(ethylsulfanyl)- N - o -tolylacrylamide . Acta Crystallographica Section E Crystallographic Communications 73:5, pages 752-754.
Crossref
Galal H. Elgemeie & Peter G. Jones. (2016) Crystal structure of 1-amino-2-oxo-2,5,6,7,8,9-hexahydro-1 H -cyclohepta[ b ]pyridine-3-carbonitrile . Acta Crystallographica Section E Crystallographic Communications 72:9, pages 1239-1241.
Crossref
Galal Elgemeie, Mamdouh Abou‐Zeid, Shahinaz Alsaid, Ali Hebishy & Hanaa Essa. (2016) ChemInform Abstract: Novel Nucleoside Analogues: First Synthesis of Pyridine‐4‐thioglycosides and Their Cytotoxic Evaluation.. ChemInform 47:6.
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