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Original Articles

Design, synthesis and anticancer evaluation of novel pyrazole, pyrazolo[3,4-d]pyrimidine and their glycoside derivatives

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Pages 275-291 | Received 05 Jul 2016, Accepted 20 Dec 2016, Published online: 21 Mar 2017

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Read on this site (5)

Asmaa A. Mandour, Ibrahim F. Nassar, Mohammed T. Abdel Aal, Mahmoud A. E. Shahin, Wael A. El-Sayed, Maghawry Hegazy, Amr Mohamed Yehia, Ahmed Ismail, Mohamed Hagras, Eslam B. Elkaeed, Hanan M. Refaat & Nasser S. M. Ismail. (2022) Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1957-1973.
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Eman Mansour, Ahmed A. Abd-Rabou, Ibrahim F. Nassar & Safaa I. Elewa. (2022) Synthesis, Docking and Anticancer Evaluation of New Pyridine-3-Carbonitrile Derivatives. Polycyclic Aromatic Compounds 42:6, pages 3523-3544.
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Fathy M. Abdelrazek, Sobhi M. Gomha, Mohamed S. Farghaly & Peter Metz. (2021) One-Pot, Three-Component Synthesis of Pyrido[2,3-d]Pyrimidinones Using Aluminate Sulfonic Acid Nanocatalyst under Grinding Technique. Polycyclic Aromatic Compounds 41:7, pages 1472-1482.
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Wenxi Cai, Jingwei Wu, Yingzhan Sun, Ailin Liu, Runling Wang, Ying Ma, Shuqing Wang & Weili Dong. (2021) Synthesis, evaluation, molecular dynamics simulation and targets identification of novel pyrazole-containing imide derivatives. Journal of Biomolecular Structure and Dynamics 39:6, pages 2176-2188.
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Ibrahim F. Nassar, Ahmed F. El Farargy, Fathy M. Abdelrazek & Zeinab Hamza. (2020) Synthesis of new uracil derivatives and their sugar hydrazones with potent antimicrobial, antioxidant and anticancer activities. Nucleosides, Nucleotides & Nucleic Acids 39:7, pages 991-1010.
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Articles from other publishers (17)

Eman M. Azmy, Mohamed Hagras, Menna A. Ewida, Ahmed S. Doghish, Emad Gamil Khidr, Ahmed A. El-Husseiny, Maher H. Gomaa, Hanan M. Refaat, Nasser S.M. Ismail, Ibrahim F. Nassar & Walaa H. Lashin. (2023) Development of pyrolo[2,3-c]pyrazole, pyrolo[2,3-d]pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological evaluation and molecular dynamics investigations. Bioorganic Chemistry 139, pages 106729.
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Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Veena Vijayan, Deepak Kumar, Jashwanth Naik, Suresh Thareja, Jagat Pal Yadav, Prateek Pathak, Maria Grishina, Amita Verma, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid Emwas & Pradeep Kumar. (2023) Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective. Pharmaceuticals 16:2, pages 299.
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Chinweike Cosmas Eze, Amarachukwu Mercy Ezeokonkwo, Izuchukwu David Ugwu, Uchenna Florence Eze, Ebuka Leonard Onyeyilim, Izuchi Solomon Attah & Ifeoma Vivian Okonkwo. (2022) Azole-Pyrimidine Hybrid Anticancer Agents: A Review of Molecular Structure, Structure Activity Relationship, and Molecular Docking. Anti-Cancer Agents in Medicinal Chemistry 22:16, pages 2822-2851.
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Ibrahim F. Nassar, Mohammed T. Abdel Aal, Wael A. El-Sayed, Mahmoud A. E Shahin, Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Mohamed Hagras, Asmaa A. Mandour & Nasser S. M. Ismail. (2022) Discovery of pyrazolo[3,4- d ]pyrimidine and pyrazolo[4,3- e ][1,2,4]triazolo[1,5- c ]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations . RSC Advances 12:23, pages 14865-14882.
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Teodora Constantinescu & Claudiu N. Lungu. (2021) Anticancer Activity of Natural and Synthetic Chalcones. International Journal of Molecular Sciences 22:21, pages 11306.
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A. A. H. Abdel Rahman, A. K. F. Shaban, I. F. Nassar, M. N. M. Yousif, D. S. El-Kady, H. M. Awad & W. A. El-Sayed. (2021) Synthesis and Anticancer Activity of New Pyrimidine and Oxadiazole Acyclic Nucleoside Analogs and Thiazolopyrimidine Derivatives. Russian Journal of General Chemistry 91:10, pages 2086-2094.
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Nour E. A. Abd El-Sattar, Eman H. K. Badawy, Wafaa H. AbdEl-Hady, Mohamed I. Abo-Alkasem, Asmaa A. MandourNasser S. M. Ismail. (2021) Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity. Chemical and Pharmaceutical Bulletin 69:1, pages 106-117.
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W. H. Lashin, I. F. Nassar, A. F. El Farargy & A. O. Abdelhamid. (2020) Synthesis of New Furanone Derivatives with Potent Anticancer Activity. Russian Journal of Bioorganic Chemistry 46:6, pages 1074-1086.
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Linda Supe, Martin Hein, Viktor O. Iaroshenko, Alexander Villinger & Peter Langer. (2020) Synthesis of glycosides of 1H-Pyrazolo[3,4-b]pyridin-3(2H)-ones. Tetrahedron 76:44, pages 131522.
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Brilliant N. Marak, Jayanta Dowarah, Laldingluaia Khiangte & Ved Prakash Singh. (2020) A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents. European Journal of Medicinal Chemistry 203, pages 112571.
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E. Mansour, E. M. Nassar, A. F. El-Farargy & F. M. Abdelrazek. (2020) An Eco-Friendly Synthesis of Some Novel Chromene-Based Heterocyclic Compounds of Biological Interest. Russian Journal of Bioorganic Chemistry 46:4, pages 582-589.
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Safaa I. Elewa, Eman Mansour, Ibrahim F. Nassar & Amal A. I. Mekawey. (2020) Synthesis of Some New Pyrazoline-Based Thiazole Derivatives and Evaluation of Their Antimicrobial, Antifungal, and Anticancer Activities. Russian Journal of Bioorganic Chemistry 46:3, pages 382-392.
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Asmaa F. Kassem, Ibrahim F. NassarMohammed T. Abdel-Aal, Hanem M. Awad & Wael A. El-Sayed. (2019) Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives. Chemical and Pharmaceutical Bulletin 67:8, pages 888-895.
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Fathy M. Abdelrazek, Peter Metz & Anne Jaeger. (2019) Some Reactions with Indane‐1,3‐dione: A Facile Synthesis of Pentacycline Heterocyclic Analogues. Journal of Heterocyclic Chemistry 56:7, pages 1939-1945.
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THATAVARTHI PADMINI & BIGALA RAJ KAMAL. (2019) Synthesis, Anti-inflammatory, Analgesic and Antipyretic Activity of Novel 1,3,5-Trisubstituted Pyrazole Derivatives. Asian Journal of Chemistry 31:6, pages 1225-1229.
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Ibrahim F. Nassar, Wael A. El-Sayed, Tamer I.M. Ragab, Al Shimaa Gamal Shalaby & Ahmed B.M. Mehany. (2019) Design, Synthesis of New Pyridine and Pyrimidine Sugar Compounds as Antagonists Targeting the ERα via Structure-Based Virtual Screening. Mini-Reviews in Medicinal Chemistry 19:5, pages 395-409.
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Ibrahim F. Nassar, Ahmed F. El Farargy & Fathy M. Abdelrazek. (2018) Synthesis and Anticancer Activity of Some New Fused Pyrazoles and Their Glycoside Derivatives. Journal of Heterocyclic Chemistry 55:7, pages 1709-1719.
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