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Nucleosides, Nucleotides & Nucleic Acids Volume 19, 2000 - Issue 3
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Original Articles

A Convenient Synthesis of 2′-Deoxy-2-fluoroadenosine; a Potential Prodrug for Suicide Gene Therapy

Abdalla E. A. Hassan Drug Discovery Division, Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, U. S. A.
,
Anita T. Shortnacy-fowler Drug Discovery Division, Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, U. S. A.
,
John A. Montgomery Drug Discovery Division, Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, U. S. A.
&
John A. Secrist III Drug Discovery Division, Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, U. S. A.
Pages 559-565 | Received 11 Oct 1999, Accepted 11 Oct 1999, Published online: 24 Sep 2006

Citations (10)

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Read on this site (2)

A.V. Silamkoti, P.W. Allan, A. E. A. Hassan, A.T. Fowler, E.J. Sorscher, W.B. Parker & J.A. Secrist. (2005) SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-FLUORO ADENINE AND 6-METHYL PURINE NUCLEOSIDE ANALOGS AS PRODRUGS FOR SUICIDE GENE THERAPY OF CANCER. Nucleosides, Nucleotides & Nucleic Acids 24:5-7, pages 881-885.
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Song Ye, Martha M. Rezende, Wei-Ping Deng & Kenneth L. Kirk. (2003) Convenient Synthesis of 2′-Deoxy-2-fluoroadenosine from 2-Fluoroadenine. Nucleosides, Nucleotides & Nucleic Acids 22:10, pages 1899-1905.
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Articles from other publishers (8)

Saumitra Sengupta & Parthasarathi Das. (2021) Application of diazonium chemistry in purine modifications: A focused review. Journal of Heterocyclic Chemistry 59:1, pages 5-21.
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L.H. Pogosian & J.I. Akopian. (2013) Purine nucleoside phosphorylase. Biomeditsinskaya Khimiya 59:5, pages 483-497.
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Stuart W. McCombie, William B. Motherwell & Matthew J. Tozer. 2004. Organic Reactions. Organic Reactions 161 432 .
Abdalla E.A. Hassan, Ahmed F. El-Farargy & Terence N. Mitchell. (2011) Synthesis of bulky tris[(dimethyl(alkyl/aryl)silyl)methyl]stannanes as radical based reducing agents. Journal of Organometallic Chemistry 696:18, pages 2971-2975.
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E. Kleinpeter. 2005. Comprehensive Organic Functional Group Transformations II. Comprehensive Organic Functional Group Transformations II 495 544 .
William B Parker, Paula W Allan, Abdalla E A Hassan, John A SecristIIIIII, Eric J Sorscher & William R Waud. (2002) Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer Gene Therapy 10:1, pages 23-29.
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Agnieszka Bzowska, Ewa Kulikowska & David Shugar. (2000) Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacology & Therapeutics 88:3, pages 349-425.
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Abdalla E. A. Hassan, Anita T. Shortnacy‐Fowler, John A. Montgomery & John A. Secrist III. (2010) ChemInform Abstract: A Convenient Synthesis of 2′‐Deoxy‐2‐fluoroadenosine; a Potential Prodrug for Suicide Gene Therapy.. ChemInform 31:44.
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