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Original Articles

Deoxynucleoside Salvage Enzymes and Tissue Specific Mitochondrial DNA Depletion

Pages 370-381 | Published online: 11 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ren Sun, Staffan Eriksson & Liya Wang. (2020) The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs. Nucleosides, Nucleotides & Nucleic Acids 39:10-12, pages 1347-1358.
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M. Löffler, E. A. Carrey & E. Zameitat. (2018) New perspectives on the roles of pyrimidines in the central nervous system. Nucleosides, Nucleotides & Nucleic Acids 37:5, pages 290-306.
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Liya Wang. (2016) Mitochondrial purine and pyrimidine metabolism and beyond. Nucleosides, Nucleotides & Nucleic Acids 35:10-12, pages 578-594.
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Articles from other publishers (11)

Naoyuki Kamatani, H.A. Jinnah, Raoul C.M. Hennekam & André B.P. van Kuilenburg. 2021. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics 183 234 .
Liya Wang, Ren Sun & Staffan Eriksson. (2020) Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency. BMC Molecular and Cell Biology 21:1.
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Fei Zhong, Shuang Liang & Zhenyu Zhong. (2019) Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression. Trends in Immunology 40:12, pages 1120-1133.
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Liya Wang, Li Zhang, Ren Sun & Staffan Eriksson. (2018) Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions. ACS Omega 3:8, pages 8971-8979.
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Sanduni U. LiyanageRose HurrenVeronique VoisinGaëlle Bridon, Xiaoming WangChangJiang XuNeil MacLeanThirushi P. SiriwardenaMarcela GrondaDana YehudaiShrivani SriskanthadevanDaina Avizonis, Aisha Shamas-DinMark D. MindenGary D. BaderRebecca Laposa & Aaron D. Schimmer. (2017) Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML. Blood 129:19, pages 2657-2666.
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Carlos Lopez-Gomez, Rebecca J. Levy, Maria J. Sanchez-Quintero, Martí Juanola-Falgarona, Emanuele Barca, Beatriz Garcia-Diaz, Saba Tadesse, Caterina Garone & Michio Hirano. (2017) Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency. Annals of Neurology 81:5, pages 641-652.
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Ren Sun & Liya Wang. (2014) Thymidine Kinase 2 Enzyme Kinetics Elucidate the Mechanism of Thymidine-Induced Mitochondrial DNA Depletion. Biochemistry 53:39, pages 6142-6150.
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Marco Scotti, Lorenzo Stella, Emily J. Shearer & Patrick J. Stover. (2013) Modeling cellular compartmentation in one‐carbon metabolism. WIREs Systems Biology and Medicine 5:3, pages 343-365.
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Shuba Krishnan, Xiaoshan Zhou, João A. Paredes, Raoul V. Kuiper, Sophie Curbo & Anna Karlsson. (2013) Transgene Expression of Drosophila melanogaster Nucleoside Kinase Reverses Mitochondrial Thymidine Kinase 2 Deficiency. Journal of Biological Chemistry 288:7, pages 5072-5079.
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Naoyuki Kamatani, H.A. Jinnah, Raoul C.M. Hennekam & André B.P. van Kuilenburg. 2013. Emery and Rimoin's Principles and Practice of Medical Genetics. Emery and Rimoin's Principles and Practice of Medical Genetics 1 38 .
Vishal V. Gandhi & David C. Samuels. (2011) Enzyme Kinetics of the Mitochondrial Deoxyribonucleoside Salvage Pathway Are Not Sufficient to Support Rapid mtDNA Replication. PLoS Computational Biology 7:8, pages e1002078.
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