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Original Articles

Induction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells

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Pages 394-399 | Published online: 11 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Courtney D DiNardo & Jorge E Cortes. (2015) New treatment for acute myelogenous leukemia. Expert Opinion on Pharmacotherapy 16:1, pages 95-106.
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Niamh Keane, Ciara Freeman, Ronan Swords & Francis J Giles. (2013) Elacytarabine: lipid vector technology under investigation in acute myeloid leukemia. Expert Review of Hematology 6:1, pages 9-24.
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RichardJ. Honeywell, Elisa Giovannetti & G.J. Peters. (2011) Determination of the Phosphorylated Metabolites of Gemcitabine and of Difluorodeoxyuridine by LCMSMS. Nucleosides, Nucleotides & Nucleic Acids 30:12, pages 1203-1213.
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Silke Henrich, Swetlana Mactier, Giles Best, StephenP. Mulligan, Ben Crossett & Richard Ian Christopherson. (2011) Fludarabine Nucleoside Modulates Nuclear “Survival and Death” Proteins in Resistant Chronic Lymphocytic Leukemia Cells. Nucleosides, Nucleotides & Nucleic Acids 30:12, pages 1181-1189.
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Articles from other publishers (13)

Mingyang Zhang, Chunlin Guo, Yifan Miao, Zhonggui He, Chutong Tian & Jin Sun. (2022) Incorporating a Lipophilic Disulfide-Bridged Linoleic Prodrug into a Self-Microemulsifying Drug Delivery System to Facilitate Oral Absorption of Paclitaxel. Molecular Pharmaceutics 20:1, pages 461-472.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 107 142 .
Nadia Fattahi, Mohammad-Ali Shahbazi, Aziz Maleki, Mehrdad Hamidi, Ali Ramazani & Hélder A. Santos. (2020) Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines. Journal of Controlled Release 326, pages 556-598.
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Peter M. Alexander, Gregory L. Kucera, Kristin M. Pladna & Timothy S. Pardee. (2020) The Novel Phospholipid Mimetic KPC34 Is Highly Active Against Acute Myeloid Leukemia with Activated Protein Kinase C. Translational Oncology 13:7, pages 100780.
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Yanyan Chu, Zhenhua Tian, Yingwei Hou & Wenbao Li. (2018) Study on the Preparation and Antileukemic Activity of New Lipophilic 1-β-D-arabinofuranosylcytosine Derivatives. Journal of Ocean University of China 17:2, pages 385-391.
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Bingjun Sun, Cong Luo, Weiping Cui, Jin Sun & Zhonggui He. (2017) Chemotherapy agent-unsaturated fatty acid prodrugs and prodrug-nanoplatforms for cancer chemotherapy. Journal of Controlled Release 264, pages 145-159.
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Jadd Shelton, Xiao Lu, Joseph A. Hollenbaugh, Jong Hyun Cho, Franck Amblard & Raymond F. Schinazi. (2016) Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs. Chemical Reviews 116:23, pages 14379-14455.
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Aditya G. Kohli, Paul H. Kierstead, Vincent J. Venditto, Colin L. Walsh & Francis C. Szoka. (2014) Designer lipids for drug delivery: From heads to tails. Journal of Controlled Release 190, pages 274-287.
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Godefridus J. Peters, Kees Smid, Leonardo Vecchi, Ietje Kathmann, Dzjemma Sarkisjan, Richard J. Honeywell, Nienke Losekoot, Osnat Ohne, Aric Orbach, Eran Blaugrund, Lak Shin Jeong, Young Bok Lee, Chang-Ho Ahn & Deog Joong Kim. (2013) Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360). Investigational New Drugs 31:6, pages 1444-1457.
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Courtney D DiNardo, Susan O’Brien, Varsha V Gandhi & Farhad Ravandi. (2013) Elacytarabine (CP-4055) in the treatment of acute myeloid leukemia. Future Oncology 9:8, pages 1073-1082.
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Auke D. Adema, Kees Smid, Nienke Losekoot, Richard J. Honeywell, Henk M. Verheul, Finn Myhren, Marit L. Sandvold & Godefridus J. Peters. (2011) Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126. Investigational New Drugs 30:5, pages 1908-1916.
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Susan O'Brien, David A. Rizzieri, Norbert Vey, Farhad Ravandi, Utz O. Krug, Mikkael A. Sekeres, Mike Dennis, Adriano Venditti, Donald A. Berry, Tove Flem Jacobsen, Karin Staudacher, Trygve Bergeland & Francis J. Giles. (2012) Elacytarabine has single‐agent activity in patients 
with advanced acute myeloid leukaemia. British Journal of Haematology 158:5, pages 581-588.
Crossref
Francis Giles, David Rizzieri, Farhad Ravandi, Ronan Swords, Tove Flem Jacobsen & Susan O’Brien. (2012) Elacytarabine, a novel 5′-elaidic acid derivative of cytarabine, and idarubicin combination is active in refractory acute myeloid leukemia. Leukemia Research 36:4, pages e71-e73.
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