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HIV Clinical Trials Volume 17, 2016 - Issue 1
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Original Articles

Clinical Outcomes of Virologically-Suppressed Patients with Pre-existing HIV-1 Drug Resistance Mutations Switching to Rilpivirine/Emtricitabine/Tenofovir Disoproxil Fumarate in the SPIRIT StudyFootnote*

Danielle P. PorterGilead Sciences Inc., Foster City, CaliforniaCorrespondence[email protected]
,
Jonathan TomaMonogram Biosciences, South San Francisco, California
,
Yuping TanMonogram Biosciences, South San Francisco, California
,
Owen SolbergMonogram Biosciences, South San Francisco, California
,
Suqin CaiMonogram Biosciences, South San Francisco, California
,
Rima KulkarniGilead Sciences Inc., Foster City, California
,
Kristen AndreattaGilead Sciences Inc., Foster City, California
,
Yolanda LieMonogram Biosciences, South San Francisco, California
,
Susan K. ChuckGilead Sciences Inc., Foster City, California
,
Frank PalellaFeinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Michael D. MillerGilead Sciences Inc., Foster City, California
&
Kirsten L. WhiteGilead Sciences Inc., Foster City, California
 show all
Pages 29-37 | Published online: 29 Jan 2016

Citations (21)

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Jose L. Casado, Marta Monsalvo, Aurora M. Rojo, María Fontecha & Miguel A. Rodriguez-Sagrado. (2018) Dolutegravir and rilpivirine for the maintenance treatment of virologically suppressed HIV-1 infection. Expert Review of Clinical Pharmacology 11:6, pages 561-570.
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Amedeo F. Capetti, Maria V. Cossu, Laura Paladini & Giuliano Rizzardini. (2018) Dolutegravir plus rilpivirine dual therapy in treating HIV-1 infection. Expert Opinion on Pharmacotherapy 19:1, pages 65-77.
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Articles from other publishers (19)

D. Armenia, R. Gagliardini, C. Alteri, V. Svicher, V. Cento, V. Borghi, A. Vergori, S. Cicalini, F. Forbici, L. Fabeni, A. Bertoli, M. Brugneti, W. Gennari, V. Malagnino, M. Andreoni, C. Mussini, A. Antinori, C.F. Perno, M.M. Santoro & F. Ceccherini-Silberstein. (2023) Temporal trend of drug-resistance and APOBEC editing in PBMC genotypic resistance tests from HIV-1 infected virologically suppressed individuals. Journal of Clinical Virology 168, pages 105551.
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A. I. Kuznetsova. (2023) The role of HIV-1 polymorphism in the pathogenesis of the disease. HIV Infection and Immunosuppressive Disorders 15:3, pages 26-37.
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Alina Kirichenko, Dmitry Kireev, Ilya Lapovok, Anastasia Shlykova, Alexey Lopatukhin, Anastasia Pokrovskaya, Marina Bobkova, Anastasiia Antonova, Anna Kuznetsova, Ekaterina Ozhmegova, Sergey Shtrek, Aleksej Sannikov, Natalia Zaytseva, Olga Peksheva, Michael Piterskiy, Aleksandr Semenov, Galina Turbina, Natalia Filoniuk, Andrey Shemshura, Valeriy Kulagin, Dmitry Kolpakov, Aleksandr Suladze, Valeriya Kotova, Lyudmila Balakhontseva, Vadim Pokrovsky & Vasiliy Akimkin. (2023) HIV-1 Drug Resistance among Treatment-Naïve Patients in Russia: Analysis of the National Database, 2006–2022. Viruses 15:4, pages 991.
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Carolyn Chu, Daniele Armenia, Charles Walworth, Maria M. Santoro & Robert W. Shafer. (2022) Genotypic Resistance Testing of HIV-1 DNA in Peripheral Blood Mononuclear Cells. Clinical Microbiology Reviews 35:4.
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Giulia Stella, Lorenzo Volpicelli, Domenico Di Carlo, Ilaria Vicenti, Luigi Celani, Franco Maggiolo, Anna Paola Callegaro, William Gennari, Daniela Francisci, Francesca Lombardi, Lorenzo Piermatteo, Antonia Bezenchek, Valeria Micheli, Barbara Rossetti & Maria Mercedes Santoro. (2022) Impact of pre‐existent drug resistance on virological efficacy of single‐tablet regimens in people living with HIV. International Journal of Antimicrobial Agents 60:3, pages 106636.
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Stefano Rusconi, Maria M. Santoro, Amedeo F. Capetti, Nicola Gianotti & Maurizio Zazzi. (2022) The future of long-acting cabotegravir plus rilpivirine therapy: deeds and misconceptions. International Journal of Antimicrobial Agents 60:3, pages 106627.
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Anna Kuznetsova, Aleksey Lebedev, Konstantin Gromov, Elena Kazennova, Maurizio Zazzi, Francesca Incardona, Anders Sönnerborg & Marina Bobkova. (2022) Pre‐existing singleton E138A mutations in the reverse transcriptase gene do not affect the efficacy of first‐line antiretroviral therapy regimens using rilpivirine in human immunodeficiency virus‐infected patients. Clinical Case Reports 10:2.
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Paul E Sax, Jürgen K Rockstroh, Anne F Luetkemeyer, Yazdan Yazdanpanah, Douglas Ward, Benoit Trottier, Armin Rieger, Hui Liu, Rima Acosta, Sean E Collins, Diana M Brainard & Hal Martin. (2021) Switching to Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Virologically Suppressed Adults With Human Immunodeficiency Virus. Clinical Infectious Diseases 73:2, pages e485-e493.
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Rima K. Acosta, Madeleine Willkom, Kristen Andreatta, Hui Liu, Ross Martin, Aiyappa Parvangada, Hal Martin, Sean Collins & Kirsten L. White. (2020) Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) From Dolutegravir (DTG)+F/TAF or DTG+F/Tenofovir Disoproxil Fumarate (TDF) in the Presence of Pre-existing NRTI Resistance. JAIDS Journal of Acquired Immune Deficiency Syndromes 85:3, pages 363-371.
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Kevin Melody, Chandra N. Roy, Christopher Kline, Mackenzie L. Cottrell, Dwayne Evans, Kathleen Shutt, Pleuni S. Pennings, Brandon F. Keele, Moses Bility, Angela D. M. Kashuba & Zandrea Ambrose. (2020) Long-Acting Rilpivirine (RPV) Preexposure Prophylaxis Does Not Inhibit Vaginal Transmission of RPV-Resistant HIV-1 or Select for High-Frequency Drug Resistance in Humanized Mice. Journal of Virology 94:8.
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Kristen E Ellis, George T Nawas, Connie Chan, Lawrence York, Julia Fisher, Elizabeth Connick & Tirdad T Zangeneh. (2020) Clinical Outcomes Following the Use of Archived Proviral HIV-1 DNA Genotype to Guide Antiretroviral Therapy Adjustment. Open Forum Infectious Diseases 7:1.
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Neha Sheth Pandit, Daniel B. Chastain, Andrea M. Pallotta, Melissa E. Badowski, Emily C. Huesgen & Sarah M. Michienzi. (2019) Simplifying ARV Therapy in the Setting of Resistance. Current Infectious Disease Reports 21:10.
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Suzanne M. McCluskey, Mark J. Siedner & Vincent C. Marconi. (2019) Management of Virologic Failure and HIV Drug Resistance. Infectious Disease Clinics of North America 33:3, pages 707-742.
Crossref
Alessia Giannini, Ilaria Vicenti, Angelo Materazzi, Adele Boccuto, Filippo Dragoni, Maurizio Zazzi & Francesco Saladini. (2019) The HIV-1 reverse transcriptase E138A natural polymorphism decreases the genetic barrier to resistance to etravirine in vitro . Journal of Antimicrobial Chemotherapy 74:3, pages 607-613.
Crossref
Kristen Andreatta, Silvia Chang, Ross Martin, Rima Acosta, Martin Daeumer, Alexander Thielen, Michael D. Miller & Kirsten L. White. (2018) HIV-1 Proviral Sequence and Treatment Outcome of Virologically Suppressed Patients Switching to Coformulated Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate. JAIDS Journal of Acquired Immune Deficiency Syndromes 79:1, pages e47-e51.
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Daniele Armenia, Mauro Zaccarelli, Vanni Borghi, William Gennari, Domenico Di Carlo, Alberto Giannetti, Federica Forbici, Ada Bertoli, Caterina Gori, Lavinia Fabeni, Carmela Pinnetti, Raffaella Marocco, Alessandra Latini, Francesca Ceccherini-Silberstein, Claudio Maria Mastroianni, Cristina Mussini, Andrea Antinori, Carlo Federico Perno & Maria Mercedes Santoro. (2018) Resistance detected in PBMCs predicts virological rebound in HIV-1 suppressed patients switching treatment. Journal of Clinical Virology 104, pages 61-64.
Crossref
Charlotte Charpentier, Isabelle Malet, Elisabeth Andre-Garnier, Alexandre Storto, Laurence Bocket, Corinne Amiel, Laurence Morand-Joubert, Camille Tumiotto, Thuy Nguyen, Anne Maillard, Audrey Rodallec, Marie Leoz, Brigitte Montes, Véronique Schneider, Jean-Christophe Plantier, Julia Dina, Coralie Pallier, Audrey Mirand, Catherine Roussel, Anne Signori-Schmuck, Stéphanie Raymond, Vincent Calvez, Constance Delaugerre, Anne-Geneviève Marcelin & Diane Descamps. (2018) Phenotypic analysis of HIV-1 E157Q integrase polymorphism and impact on virological outcome in patients initiating an integrase inhibitor-based regimen. Journal of Antimicrobial Chemotherapy 73:4, pages 1039-1044.
Crossref
D. Armenia, D. Di Carlo, A. Calcagno, G. Vendemiati, F. Forbici, A. Bertoli, G. Berno, S. Carta, F. Continenza, V. Fedele, R. Bellagamba, S. Cicalini, A. Ammassari, R. Libertone, M. Zaccarelli, V. Ghisetti, M. Andreoni, F. Ceccherini-Silberstein, S. Bonora, G. Di Perri, A. Antinori, C. F. Perno & M. M. Santoro. (2016) Pre-existent NRTI and NNRTI resistance impacts on maintenance of virological suppression in HIV-1-infected patients who switch to a tenofovir/emtricitabine/rilpivirine single-tablet regimen. Journal of Antimicrobial Chemotherapy, pages dkw512.
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Santiago Avila-Ríos, Claudia García-Morales, Margarita Matías-Florentino, Daniela Tapia-Trejo, Bismarck F. Hernández-Álvarez, Sumaya E. Moreira-López, Carlos J. Quant-Durán, Guillermo Porras-Cortés & Gustavo Reyes-Terán. (2016) HIV Drug Resistance in Antiretroviral Treatment-Naïve Individuals in the Largest Public Hospital in Nicaragua, 2011-2015. PLOS ONE 11:10, pages e0164156.
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