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Original Article

HIV-coinfected patients respond worse to direct-acting antiviral-based therapy against chronic hepatitis C in real life than HCV-monoinfected individuals: a prospective cohort study

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Francesco Pes, Simona Onali, Cinzia Balestrieri, Goffredo Angioni, Francesco Ortu, Paola Piano, Barca Lucia, Rosetta Scioscia, Elija Princic, Anna Chiara Bolliri, Michele Casale, Alessandra Cola, Maria Conti, Lorenza Peddis, Giancarlo Serra, Stefano Vacca, Martina Loi, Enrico Urru, Claudia Murru, Laura Matta, Stefano Del Giacco, Sergio Babudieri, Ivana Maida & Luchino Chessa. (2022) HCV treatment in Sardinian HIV-HCV coinfected patients: a real-life perspective study on safety, efficacy, and immune reconstitution. Expert Review of Anti-infective Therapy 20:11, pages 1509-1516.
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Jenny Bischoff, Stefan Mauss, Christiane Cordes, Thomas Lutz, Stefan Scholten, Markus Cornberg, Michael P. Manns, Axel Baumgarten & Jürgen K. Rockstroh. (2018) Impact of CD4+ blood cell count and HIV viral load on treatment response with direct acting antivirals in HIV and HCV coinfected patients: insights from the German Hepatitis C-Registry. HIV Clinical Trials 19:6, pages 225-234.
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Rachel Sacks-Davis, Alisa E Pedrana, Nick Scott, Joseph S Doyle & Margaret E Hellard. (2018) Eliminating HIV/HCV co-infection in gay and bisexual men: is it achievable through scaling up treatment?. Expert Review of Anti-infective Therapy 16:5, pages 411-422.
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P. de Leuw & C. Stephan. (2018) Protease inhibitor therapy for hepatitis C virus-infection. Expert Opinion on Pharmacotherapy 19:6, pages 577-587.
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Daniel Sepúlveda-Crespo, María Belén Yélamos, Cristina Díez, Julián Gómez, Víctor Hontañón, Francisco Torresano-Felipe, Juan Berenguer, Juan González-García, Luis Ibañez-Samaniego, Elva Llop, Antonio Olveira, Javier Martínez, Salvador Resino & Isidoro Martínez. (2022) Negative impact of HIV infection on broad-spectrum anti-HCV neutralizing antibody titers in HCV-infected patients with advanced HCV-related cirrhosis. Biomedicine & Pharmacotherapy 150, pages 113024.
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Kevin Guerra, Angelica Bocour, Miranda S. Moore & Ann Winters. (2022) Detection of Recurrent Hepatitis C Viremia Using Surveillance Data, New York City. Journal of Public Health Management and Practice 28:2, pages 126-129.
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Elias Kouroumalis & Argyro Voumvouraki. (2022) Hepatitis C virus: A critical approach to who really needs treatment. World Journal of Hepatology 14:1, pages 1-44.
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Samaa T. Gobran, Petronela Ancuta & Naglaa H. Shoukry. (2021) A Tale of Two Viruses: Immunological Insights Into HCV/HIV Coinfection. Frontiers in Immunology 12.
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Mathieu Chalouni, Stanislas Pol, Philippe Sogni, Hélène Fontaine, Karine Lacombe, Jean Marc-Lacombe, Laure Esterle, Celine Dorival, Marc Bourlière, Firouzé Bani-Sadr, Victor de Ledinghen, David Zucman, Dominique Larrey, Dominique Salmon, Fabrice Carrat, Linda Wittkop, D. Salmon, L. Wittkop, P. Sogni, L. Esterle, P. Trimoulet, J. Izopet, L. Serfaty, V. Paradis, B. Spire, P. Carrieri, M.A. Valantin, G. Pialoux, J. Chas, I. Poizot-Martin, K. Barange, A. Naqvi, E. Rosenthal, A. Bicart-See, O. Bouchaud, A. Gervais, C. Lascoux-Combe, C. Goujard, K. Lacombe, C. Duvivier, D. Neau, P. Morlat, F. Bani-Sadr, L. Meyer, F. Boufassa, B. Autran, A.M. Roque, C. Solas, H. Fontaine, D. Costagliola, L. Piroth, A. Simon, D. Zucman, F. Boué, P. Miailhes, E. Billaud, H. Aumaitre, D. Rey, G. Peytavin, V. Petrov-Sanchez & D. Lebrasseur-Longuet. (2021) Increased mortality in HIV/HCV-coinfected compared to HCV-monoinfected patients in the DAA era due to non-liver-related death. Journal of Hepatology 74:1, pages 37-47.
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Jenny Bischoff & Jürgen K. Rockstroh. (2020) Are there any challenges left in hepatitis C virus therapy of HIV-infected patients?. International Journal of Antimicrobial Agents 56:1, pages 105527.
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Ahmed Cordie, Aisha Elsharkawy, Shereen Abdel Alem, Safa Meshaal, Wafaa El Akel, Zeinab Abdellatif, Walid Kamal, Mahmoud Al Askalany, Sherif Kamel, Hossam Abdel Aziz, Amr Kandeel & Gamal Esmat. (2020) Sustained virologic response and changes in liver fibrosis parameters following 12-wk administration of generic sofosbuvir and daclatasvir in HIV/HCV-coinfected patients with HCV genotype 4 infection. Transactions of The Royal Society of Tropical Medicine and Hygiene 114:4, pages 232-240.
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Caroline Schmidbauer, David Chromy, Victor Schmidbauer, David Bauer, Michael Apata, Dung Nguyen, Mattias Mandorfer, Benedikt Simbrunner, Armin Rieger, Florian Mayer, Ralf Schmidt, Heidemarie Holzmann, Michael Trauner, Michael Gschwantler & Thomas Reiberger. (2020) Epidemiological trends in HCV transmission and prevalence in the Viennese HIV+ population. Liver International 40:4, pages 787-796.
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Soraia M. Machado, Aline G. Vigani, Andrea G. Leite, Ana Claudia M. Diaz, Paulo Roberto A. Ferreira, Dimas Carnaúba-Júnior, Simone B. Tenore, Carlos Eduardo Brandão-Mello, Mario P. Gonzalez, Fabiana Siroma, Kleber D. Prado, Delzi V. Nunes, Gaspar Lisboa-Neto, João Renato R. Pinho, Fernanda M. Malta, Raymundo S. Azevedo, Steven S. Witkin & Maria Cássia Mendes-Correa. (2020) Effectiveness of direct-acting antivirals for hepatitis C virus infection in hepatitis C/HIV coinfected individuals. Medicine 99:30, pages e21270.
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Bo Wang, Luise Krüger, Patrycja Machnowska, Amare Eshetu, Barbara Gunsenheimer-Bartmeyer, Viviane Bremer, Andrea Hauser, Norbert Bannert & C.-Thomas Bock. (2019) Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o. Virology Journal 16:1.
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Juan Macías, Luis E. Morano, Francisco Téllez, Rafael Granados, Antonio Rivero-Juárez, Rosario Palacios, MªJosé Ríos, Dolores Merino, Montserrat Pérez-Pérez, Antonio Collado, Blanca Figueruela, Aitana Morano, Carolina Freyre-Carrillo, José M. Martín, Antonio Rivero, Federico García & Juan A. Pineda. (2019) Response to direct-acting antiviral therapy among ongoing drug users and people receiving opioid substitution therapy. Journal of Hepatology 71:1, pages 45-51.
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Juan Berenguer, José Luis Calleja, María Luisa Montes, Ángela Gil, Ana Moreno, Rafael Bañares, Teresa Aldámiz-Echevarría, Agustín Albillos, María Jesús Téllez, Antonio Olveira, Lourdes Domínguez, Inmaculada Fernández, Javier García-Samaniego, Benjamín A Polo, Beatriz Álvarez, Pablo Ryan, José Barrio, María J Devesa, Laura Benítez, Ignacio Santos, Luisa García Buey, José Sanz, Elvira Poves, Juan E Losa, Conrado Fernández-Rodríguez, Inmaculada Jarrín, María J Calvo & Juan González-García. (2019) HIV Coinfection Predicts Failure of Ledipasvir/Sofosbuvir in Treatment-Naïve Noncirrhotic Patients With HCV Genotype 1. Open Forum Infectious Diseases 6:5.
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María Ángeles Campos Fernández de Sevilla, Marta Gallego Úbeda, Miriam Heredia Benito, Emilio García-Cabrera, Beatriz Monje García, María Tovar Pozo, Laura Delgado Téllez de Cepeda & Irene Iglesias-Peinado. (2019) Implementation of a pharmaceutical care program for patients with hepatitis C treated with new direct-action antivirals. International Journal of Clinical Pharmacy 41:2, pages 488-495.
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Edward R Cachay, Alvaro Mena, Luis Morano, Laura Benitez, Ivana Maida, Craig Ballard, Lucas Hill, Francesca Torriani, Angeles Castro, Elena Dore, Sheila Castro, Carmen de Mendoza Fernández, Vicente Soriano & Wm C Mathews. (2019) Predictors of Hepatitis C Treatment Failure After Using Direct-Acting Antivirals in People Living With Human Immunodeficiency Virus. Open Forum Infectious Diseases 6:3.
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Paula Eckardt, Jianli Niu, Angela Savage, Tara Griffin & Elizabeth Sherman. (2019) Effect of Health Insurance on Hepatitis C Sustained Virologic Response Rates to Sofosbuvir-Based Treatment Regimens in a South Florida Community Hospital. Journal of the International Association of Providers of AIDS Care (JIAPAC) 18, pages 232595821983559.
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Juan Macías, Francisco Téllez, Antonio Rivero-Juárez, Rosario Palacios, Luis E. Morano, Dolores Merino, Antonio Collado, Lucio García-Fraile, Mohamed Omar & Juan A. Pineda. (2019) Early emergence of opportunistic infections after starting direct-acting antiviral drugs in HIV/HCV-coinfected patients. Journal of Viral Hepatitis 26:1, pages 48-54.
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Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D’Offizi, Adriano Pellicelli, Orlando Armignacco, Francesco Saverio Mennini, Massimo Siciliano, Enrico Girardi, Vincenzo Panella & Giuseppe Ippolito. (2018) Impact of new DAA therapy on real clinical practice: a multicenter region-wide cohort study. BMC Infectious Diseases 18:1.
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Do Young Kim. (2018) Efficacy of Direct-Acting Antivirals in Patients with Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: A Gap between Clinical Trial and Real Practice. Gut and Liver 12:6, pages 609-610.
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Vijay Gayam, Muhammad Rajib Hossain, Mazin Khalid, Sandipan Chakaraborty, Osama Mukhtar, Sumit Dahal, Amrendra Kumar Mandal, Arshpal Gill, Pavani Garlapati, Sreedevi Ramakrishnaiah, Khalid Mowyad, Jagannath Sherigar, Mohammed Mansour & Smruti Mohanty. (2018) Real-World Clinical Efficacy and Tolerability of Direct-Acting Antivirals in Hepatitis C Monoinfection Compared to Hepatitis C/Human Immunodeficiency Virus Coinfection in a Community Care Setting. Gut and Liver 12:6, pages 694-703.
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Jose L. Calleja, Juan Macias, Xavier Forns, Federico Garcia, Marina Berenguer, Miguel Garcia Deltoro, Maria Buti, Rafael Granados, Jose A. Carrion, Luis Morano, Inmaculada Fernandez, Pablo Coste & Juan A. Pineda. (2018) Guía de tratamiento de la infección por virus de la hepatitis C. Asociación Española para el Estudio del Hígado (AEEH). Gastroenterología y Hepatología 41:9, pages 597-608.
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Jose L. Calleja, Juan Macias, Xavier Forns, Federico Garcia, Marina Berenguer, Miguel Garcia Deltoro, Maria Buti, Rafael Granados, Jose A. Carrion, Luis Morano, Inmaculada Fernandez, Pablo Coste, Juan A. Pineda, José Luis Calleja, Xavier Forns, Juan Macías, Juan Antonio Pineda, Marina Berenguer, María Buti, Jose Antonio Carrión, Inmaculada Fernández, Federico García, Miguel García Deltoro, Rafael Granados & Luis Morano. (2018) Guidelines on treatment of hepatitis C virus infection. Spanish Association for the Study of the Liver (AEEH). Gastroenterología y Hepatología (English Edition) 41:9, pages 597-608.
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Cameron Sikavi, Lisa Najarian & Sammy Saab. (2018) Similar Sustained Virologic Response in Real-World and Clinical Trial Studies of Hepatitis C/Human Immunodeficiency Virus Coinfection. Digestive Diseases and Sciences 63:11, pages 2829-2839.
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Viola Guardigni, Valeria Cento, Stefano Ianniruberto, Lorenzo Badia, Marianna Aragri, Matteo Conti, Carlo Federico Perno, Pierluigi Viale, Francesca Ceccherini-Silberstein & Gabriella Verucchi. (2018) HCV very late relapse following an atypical viral kinetics in a HIV patient treated for hepatitis C with direct-acting antivirals. Infection 46:5, pages 717-720.
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Nicolás Merchante, Antonio Rivero-Juárez, Francisco Téllez, Dolores Merino, María J Ríos-Villegas, Marina Villalobos, Mohamed Omar, Pilar Rincón, Antonio Rivero, Montserrat Pérez-Pérez, Miguel Raffo, Inmaculada López-Montesinos, Rosario Palacios, María A Gómez-Vidal, Juan Macías, Juan A Pineda, Nicolás Merchante, Pilar Rincón, María Iglesias, Luis M Real, Juan Macías, Juan A Pineda, Antonio Rivero Juárez, Teresa Brieva, Angela Camacho Espejo, Antonio Rivero, Francisco Téllez, Dolores Merino, Miguel Raffo, María J Ríos Villegas, Inmaculada López Montesinos, Marina Villalobos, Rosario Palacios, Jesús Santos, Mohamed Omar, Maria A Gómez Vidal & Monserrat Pérez Pérez. (2018) Sustained virological response to direct-acting antiviral regimens reduces the risk of hepatocellular carcinoma in HIV/HCV-coinfected patients with cirrhosis. Journal of Antimicrobial Chemotherapy 73:9, pages 2435-2443.
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J Bischoff, S Mauss, C Cordes, T Lutz, S Scholten, A Moll, H Jäger, M Cornberg, MP Manns, A Baumgarten & JK Rockstroh. (2018) Rates of sustained virological response 12 weeks after the scheduled end of direct-acting antiviral (DAA)-based hepatitis C virus (HCV) therapy from the National German HCV registry: does HIV coinfection impair the response to DAA combination therapy?. HIV Medicine 19:4, pages 299-307.
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Vasily Isakov, Natalia Gankina, Viacheslav Morozov, Kathryn Kersey, Sophia Lu, Anu Osinusi, Evguenia Svarovskaia, Diana M. Brainard, Riina Salupere, Elena Orlova-Morozova & Konstantin Zhdanov. (2017) Ledipasvir–Sofosbuvir for 8 Weeks in Non-Cirrhotic Patients with Previously Untreated Genotype 1 HCV Infection ± HIV-1 Co-Infection. Clinical Drug Investigation 38:3, pages 239-247.
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Cameron Sikavi, Phillip H. Chen, Alex D. Lee, Elena G. Saab, Gina Choi & Sammy Saab. (2018) Hepatitis C and human immunodeficiency virus coinfection in the era of direct‐acting antiviral agents: No longer a difficult‐to‐treat population. Hepatology 67:3, pages 847-857.
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