Advanced search
Publication Cover
Journal of Toxicology and Environmental Health, Part A
Current Issues
Volume 65, 2002 - Issue 16
Submit an article Journal homepage
124
Views
46
CrossRef citations to date
0
Altmetric
Original Articles

EFFECTS OF VOMITOXIN (DEOXYNIVALENOL) ON THE BINDING OF TRANSCRIPTION FACTORS AP-1, NF-κB, AND NF-IL6 IN RAW 264.7 MACROPHAGE CELLS

Shu-Shyan Wong Department of Food Science and Human Nutrition and Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan, USA
,
Hui-Ren Zhou Department of Food Science and Human Nutrition and Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan, USA
&
James J. Pestka Department of Food Science and Human Nutrition, Department of Microbiology and Molecular Genetics, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan, USA
Pages 1161-1180 | Published online: 05 Apr 2010

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Alessandra Mezzelani, Martina Landini, Francesco Facchiano, Maria Elisabetta Raggi, Laura Villa, Massimo Molteni, Barbara De Santis, Carlo Brera, Anna Maria Caroli, Luciano Milanesi & Anna Marabotti. (2015) Environment, dysbiosis, immunity and sex-specific susceptibility: A translational hypothesis for regressive autism pathogenesis. Nutritional Neuroscience 18:4, pages 145-161.
Read now
Ruoting Pei & Claudia K. Gunsch. (2011) Cytotoxic and proinflammatory response of RAW 264.7 cells to differentially fractionated fungal fragments. Toxicological & Environmental Chemistry 93:7, pages 1386-1398.
Read now
J.J. Pestka. (2008) Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food Additives & Contaminants: Part A 25:9, pages 1128-1140.
Read now
JamesJ. Pestka & AlexaT. Smolinski. (2005) Deoxynivalenol: Toxicology and Potential Effects on Humans. Journal of Toxicology and Environmental Health, Part B 8:1, pages 39-69.
Read now
Jong Woo Yoon, Jae Ku Kang, Kang Ro Lee, Hyang Woo Lee, Jeung Whan Han, Dong Wan Seo & Yong Kee Kim. (2005) β-Carboline Alkaloid Suppresses NF-κB Transcriptional Activity Through Inhibition of IKK Signaling Pathway. Journal of Toxicology and Environmental Health, Part A 68:23-24, pages 2005-2017.
Read now
Shawn Kinser, Qunshan Jia, Maioxing Li, Ashley Laughter, PaulD. Cornwell, J. Christopher Corton & JamesJ. Pestka. (2004) GENE EXPRESSION PROFILING IN SPLEENS OF DEOXYNIVALENOL-EXPOSED MICE: IMMEDIATE EARLY GENES AS PRIMARY TARGETS. Journal of Toxicology and Environmental Health, Part A 67:18, pages 1423-1441.
Read now
Winfried Drochner, Margit Schollenberger, Hans-Peter Piepho, Simone Götz, Uwe Lauber, Myqerem Tafaj, Franc Klobasa, Ulrike Weiler, Rolf Claus & Martin Steffl. (2004) Serum IgA-Promoting Effects Induced by Feed Loads Containing Isolated Deoxynivalenol (DON) in Growing Piglets. Journal of Toxicology and Environmental Health, Part A 67:13, pages 1051-1067.
Read now
Yuseok Moon, Rebecca Uzarski & James Pestka. (2003) Relationship of Trichothecene Structure to Cox-2 Induction in the Macrophage: Selective Action of Type B (8-Keto) Trichothecenes. Journal of Toxicology and Environmental Health, Part A 66:20, pages 1967-1983.
Read now

Articles from other publishers (37)

Xiaoxian Zheng, Defeng Xu, Lijun Sun, Xiaoming Qin & Ying Zhang. (2022) Inflammation and apoptosis pathways mediated the stress response of Litopenaeus vannamei to acute cold and air exposure during waterless live transportation: Based on ultrastructure and transcriptome. Fish & Shellfish Immunology 131, pages 391-400.
Crossref
Jingxuan Wang, Wouter Bakker, Weijia Zheng, Laura de Haan, Ivonne M. C. M. Rietjens & Hans Bouwmeester. (2022) Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells. Archives of Toxicology 96:5, pages 1473-1482.
Crossref
Jamie M. Hooft & Dominique P. Bureau. (2021) Deoxynivalenol: Mechanisms of action and its effects on various terrestrial and aquatic species. Food and Chemical Toxicology 157, pages 112616.
Crossref
Fatma J. Al‐Saeedi. (2020) Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells. Clinical and Experimental Pharmacology and Physiology 48:3, pages 389-400.
Crossref
Hongyan Guo, Jian Ji, Kaimin Wei, Jiadi Sun, Yinzhi Zhang & Xiulan Sun. (2021) MAPK/AP-1 and ROS participated in ratio- and time-dependent interaction effects of deoxynivalenol and cadmium on HT-29 cells. Food and Chemical Toxicology 148, pages 111921.
Crossref
Lydia Woelflingseder, Nadia Gruber, Gerhard Adam & Doris Marko. (2020) Pro-Inflammatory Effects of NX-3 Toxin Are Comparable to Deoxynivalenol and not Modulated by the Co-Occurring Pro-Oxidant Aurofusarin. Microorganisms 8:4, pages 603.
Crossref
Junmei Wang, Yongcheng Jin, Shunlu Wu, Hao Yu, Yun Zhao, Hengtong Fang, Jinglin Shen, Changhai Zhou, Yurong Fu, Ruihua Li, Rui Wang, Junxiong Wang, Kexin Zheng, Qingsong Fan, Bojiong Chen & Jing Zhang. (2019) Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells. Journal of Animal Physiology and Animal Nutrition 103:6, pages 1663-1674.
Crossref
Jian Ji, Wenshu Gu, Chao Sun, Jiadi Sun, Hui Jiang, Yinzhi Zhang & Xiulan Sun. (2016) A novel recombinant cell fluorescence biosensor based on toxicity of pathway for rapid and simple evaluation of DON and ZEN. Scientific Reports 6:1.
Crossref
Xiao Pan, Douglas A. Whitten, Curtis G. Wilkerson & James J. Pestka. (2014) Dynamic Changes in Ribosome-Associated Proteome and Phosphoproteome During Deoxynivalenol-Induced Translation Inhibition and Ribotoxic Stress. Toxicological Sciences 138:1, pages 217-233.
Crossref
Xiao Pan, Douglas A. Whitten, Ming Wu, Christina Chan, Curtis G. Wilkerson & James J. Pestka. (2013) Early Phosphoproteomic Changes in the Mouse Spleen During Deoxynivalenol-Induced Ribotoxic Stress. Toxicological Sciences 135:1, pages 129-143.
Crossref
K. Kullik, B. Brosig, S. Kersten, H. Valenta, A.-K. Diesing, P. Panther, N. Reinhardt, J. Kluess, H.-J. Rothkötter, G. Breves & S. Dänicke. (2013) Interactions between the Fusarium toxin deoxynivalenol and lipopolysaccharides on the in vivo protein synthesis of acute phase proteins, cytokines and metabolic activity of peripheral blood mononuclear cells in pigs. Food and Chemical Toxicology 57, pages 11-20.
Crossref
K. Kullik, B. Brosig, S. Kersten, H. Valenta, A.-K. Diesing, P. Panther, N. Reinhardt, J. Kluess, H.-J. Rothkötter, G. Breves & S. Dänicke. (2013) Interactions of deoxynivalenol and lipopolysaccharides on tissue protein synthesis in pigs. World Mycotoxin Journal 6:2, pages 185-197.
Crossref
Xiao Pan, Douglas A. Whitten, Ming Wu, Christina Chan, Curtis G. Wilkerson & James J. Pestka. (2013) Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage. Toxicology and Applied Pharmacology 268:2, pages 201-211.
Crossref
Kaiyu He, Xiao Pan, Hui-Ren Zhou & James J. Pestka. (2013) Modulation of Inflammatory Gene Expression by the Ribotoxin Deoxynivalenol Involves Coordinate Regulation of the Transcriptome and Translatome. Toxicological Sciences 131:1, pages 153-163.
Crossref
Xu Wang, Qin Liu, Awais Ihsan, Lingli Huang, Menghong Dai, Haihong Hao, Guyue Cheng, Zhenli Liu, Yulian Wang & Zonghui Yuan. (2012) JAK/STAT Pathway Plays a Critical Role in the Proinflammatory Gene Expression and Apoptosis of RAW264.7 Cells Induced by Trichothecenes as DON and T-2 Toxin. Toxicological Sciences 127:2, pages 412-424.
Crossref
J. Pestka. (2010) Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin Journal 3:4, pages 323-347.
Crossref
James J. Pestka. (2010) Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Archives of Toxicology 84:9, pages 663-679.
Crossref
Rajashree Krishnaswamy, S. Niranjali Devaraj & V. Vijaya Padma. (2010) Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: Prevention of NF-κB nuclear localization and down regulation of NF-κB and Cyclo-Oxygenase – 2 expression. Free Radical Biology and Medicine 49:1, pages 50-60.
Crossref
James J. Pestka. (2010) Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae. Toxins 2:6, pages 1300-1317.
Crossref
James J. Pestka. (2010) n-3 Polyunsaturated fatty acids and autoimmune-mediated glomerulonephritis. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 82:4-6, pages 251-258.
Crossref
Pavlina Sobrova, Vojtech Adam, Anna Vasatkova, Miroslava Beklova, Ladislav Zeman & Rene Kizek. (2010) Deoxynivalenol and its toxicity. Interdisciplinary Toxicology 3:3.
Crossref
Susanne Döll, Jan A. Schrickx, Hana Valenta, Sven Dänicke & Johanna Fink-Gremmels. (2009) Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. Toxicology Letters 189:2, pages 121-129.
Crossref
Khairul I. Ansari, Imran Hussain, Hriday K. Das & Subhrangsu S. Mandal. (2009) Overexpression of human histone methylase MLL1 upon exposure to a food contaminant mycotoxin, deoxynivalenol. FEBS Journal 276:12, pages 3299-3307.
Crossref
Carina Nielsen, Harald Lippke, Andrea Didier, Richard Dietrich & Erwin Märtlbauer. (2009) Potential of deoxynivalenol to induce transcription factors in human hepatoma cells. Molecular Nutrition & Food Research 53:4, pages 479-491.
Crossref
Jacqueline Van De Walle, Béatrice Romier, Yvan Larondelle & Yves-Jacques Schneider. (2008) Influence of deoxynivalenol on NF-κB activation and IL-8 secretion in human intestinal Caco-2 cells. Toxicology Letters 177:3, pages 205-214.
Crossref
Jennifer S. Gray & James J. Pestka. (2007) Transcriptional Regulation of Deoxynivalenol-Induced IL-8 Expression in Human Monocytes. Toxicological Sciences 99:2, pages 502-511.
Crossref
Zahidul Islam, Jennifer S. Gray & James J. Pestka. (2006) p38 mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. Toxicology and Applied Pharmacology 213:3, pages 235-244.
Crossref
Qunshan Jia, Hui-Ren Zhou, Yuhui Shi & James J Pestka. (2006) Docosahexaenoic Acid Consumption Inhibits Deoxynivalenol-Induced CREB/ATF1 Activation and IL-6 Gene Transcription in Mouse Macrophages. The Journal of Nutrition 136:2, pages 366-372.
Crossref
Maoxiang Li, Christopher F. Cuff & James Pestka. (2005) Modulation of Murine Host Response to Enteric Reovirus Infection by the Trichothecene Deoxynivalenol. Toxicological Sciences 87:1, pages 134-145.
Crossref
Hui-Ren Zhou, Qunshan Jia & James J. Pestka. (2005) Ribotoxic Stress Response to the Trichothecene Deoxynivalenol in the Macrophage Involves the Src Family Kinase Hck. Toxicological Sciences 85:2, pages 916-926.
Crossref
Shawn Kinser, Maioxing Li, Qunshan Jia & James J. Pestka. (2005) Truncated deoxynivalenol-induced splenic immediate early gene response in mice consuming (n-3) polyunsaturated fatty acids. The Journal of Nutritional Biochemistry 16:2, pages 88-95.
Crossref
James J. Pestka, Hui-Ren Zhou, Y. Moon & Y.J. Chung. (2004) Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicology Letters 153:1, pages 61-73.
Crossref
. (2004) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to Deoxynivalenol (DON) as undesirable substance in animal feed. EFSA Journal 2:6, pages 73.
Crossref
Yuseok Moon & James J. Pestka. (2003) Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil. The Journal of Nutritional Biochemistry 14:12, pages 717-726.
Crossref
Yong-Joo Chung, Hui-Ren Zhou & James J Pestka. (2003) Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-α expression by deoxynivalenol (vomitoxin). Toxicology and Applied Pharmacology 193:2, pages 188-201.
Crossref
H.-R. Zhou, A. S. Lau & J. J. Pestka. (2003) Role of Double-Stranded RNA-Activated Protein Kinase R (PKR) in Deoxynivalenol-Induced Ribotoxic Stress Response. Toxicological Sciences 74:2, pages 335-344.
Crossref
James J. Pestka. (2003) Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. Toxicology Letters 140-141, pages 287-295.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.