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Original Articles

A Physiologically Based Pharmacokinetic Model for Acrylamide and Its Metabolite, Glycidamide, in the Rat

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Pages 253-274 | Published online: 07 Jan 2011

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Daria Kraus, Dennis Rokitta, Uwe Fuhr & Dorota Tomalik-Scharte. (2013) The role of human cytochrome P450 enzymes in metabolism of acrylamide in vitro. Toxicology Mechanisms and Methods 23:5, pages 346-351.
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Marta Pingarilho, Nuno G. Oliveira, Célia Martins, Ana Sofia Fernandes, João Pereira de Lima, José Rueff & Jorge Francisco Gaspar. (2012) Genetic Polymorphisms in Detoxification and DNA Repair Genes and Susceptibility to Glycidamide-Induced DNA Damage. Journal of Toxicology and Environmental Health, Part A 75:13-15, pages 920-933.
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Taewon Lee, Mugimane G. Manjanatha, Anane Aidoo, Carrie L. Moland, William S. Branham, James C. Fuscoe, Akhtar A. Ali & Varsha G. Desai. (2012) Expression Analysis of Hepatic Mitochondria-Related Genes in Mice Exposed to Acrylamide and Glycidamide. Journal of Toxicology and Environmental Health, Part A 75:6, pages 324-339.
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Katherine Walker, Dale Hattis, Abel Russ, Bob Sonawane & Gary Ginsberg. (2007) Approaches to Acrylamide Physiologically Based Toxicokinetic Modeling for Exploring Child–adult Dosimetry Differences. Journal of Toxicology and Environmental Health, Part A 70:24, pages 2033-2055.
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A. Shipp, G. Lawrence, R. Gentry, T. McDonald, H. Bartow, J. Bounds, N. Macdonald, H. Clewell, B. Allen & C. Van Landingham. (2006) Acrylamide: Review of Toxicity Data and Dose-Response Analyses for Cancer and Noncancer Effects. Critical Reviews in Toxicology 36:6-7, pages 481-608.
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T. Bjellaas, K. Janák, E. Lundanes, L. Kronberg & G. Becher. (2005) Determination and quantification of urinary metabolites after dietary exposure to acrylamide. Xenobiotica 35:10-11, pages 1003-1018.
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Articles from other publishers (39)

Yaoran Li, Jiahao Jiang, Qiao Wang, Li Zhu, Wei Jia, Xinyu Chen & Yu Zhang. (2022) The construction and application of physiologically based toxicokinetic models for acrylamide, glycidamide and their biomarkers in rats and humans. Chemosphere 292, pages 133458.
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Mengyao Zhao, Boya Zhang & Linlin Deng. (2022) The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives. Frontiers in Nutrition 9.
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Yu-Syuan Luo, Tai-Ying Long, Su-Yin Chiang & Kuen-Yuh Wu. (2021) Characterization of primary glutathione conjugates with acrylamide and glycidamide: Toxicokinetic studies in Sprague Dawley rats treated with acrylamide. Chemico-Biological Interactions 350, pages 109701.
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Birgitte Lindeman, Ylva Johansson, Mathilda Andreassen, Trine Husøy, Hubert Dirven, Tim Hofer, Helle K. Knutsen, Ida H. Caspersen, Kristine Vejrup, Ragnhild E. Paulsen, Jan Alexander, Anna Forsby & Oddvar Myhre. (2021) Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps. Reproductive Toxicology 101, pages 93-114.
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Alam Zeb. 2019. Food Frying. Food Frying 293 325 .
Rajeev K. Singla, Ashok K. Dubey, Sara M. Ameen, Shana Montalto & Salvatore ParisiRajeev K. Singla, Ashok K. Dubey, Sara M. Ameen, Shana Montalto & Salvatore Parisi. 2018. Analytical Methods for the Assessment of Maillard Reactions in Foods. Analytical Methods for the Assessment of Maillard Reactions in Foods 37 45 .
Hitesh V. Motwani, Cecilia Frostne & Margareta Törnqvist. (2017) Parallelogram based approach for in vivo dose estimation of genotoxic metabolites in humans with relevance to reduction of animal experiments. Scientific Reports 7:1.
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R. Kiwamoto, D. Ploeg, I.M.C.M. Rietjens & A. Punt. (2016) Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling. Toxicology in Vitro 31, pages 114-125.
Crossref
. (2015) Scientific Opinion on acrylamide in food. EFSA Journal 13:6.
Crossref
R. Kiwamoto, A. Spenkelink, I.M.C.M. Rietjens & A. Punt. (2015) An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes. Toxicology and Applied Pharmacology 282:1, pages 108-117.
Crossref
Franco Pedreschi, María Salomé Mariotti & Kit Granby. (2014) Current issues in dietary acrylamide: formation, mitigation and risk assessment. Journal of the Science of Food and Agriculture 94:1, pages 9-20.
Crossref
R. Kiwamoto, A. Spenkelink, I. M. C. M. Rietjens & A. Punt. (2013) A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in human including interindividual variation indicates efficient detoxification and a negligible genotoxicity risk. Archives of Toxicology 87:9, pages 1725-1737.
Crossref
R.S. DeWoskin, L.M. Sweeney, J.G. Teeguarden, R. Sams2nd2nd & J. Vandenberg. (2013) Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamide. Food and Chemical Toxicology 58, pages 506-521.
Crossref
Reiko Kiwamoto, Ivonne M. C. M. Rietjens & Ans Punt. (2012) A Physiologically Based in Silico Model for trans -2-Hexenal Detoxification and DNA Adduct Formation in Rat . Chemical Research in Toxicology 25:12, pages 2630-2641.
Crossref
Yu-Fang Huang, Su-Yin Chiang, Saou-Hsing Liou, Mei-Lien Chen, Ming-Feng Chen, Shi-Nian Uang & Kuen-Yuh Wu. (2012) The modifying effect of CYP2E1, GST, and mEH genotypes on the formation of hemoglobin adducts of acrylamide and glycidamide in workers exposed to acrylamide. Toxicology Letters 215:2, pages 92-99.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 54 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 52 .
Gema Arribas-Lorenzo & Francisco J. Morales. 2012. Advances in Molecular Toxicology Volume 6. Advances in Molecular Toxicology Volume 6 163 193 .
Yu-Fang Huang, Mei-Lien Chen, Saou-Hsing Liou, Ming-Feng Chen, Shi-Nian Uang & Kuen-Yuh Wu. (2011) Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide. Toxicology Letters 203:2, pages 118-126.
Crossref
Edoardo Capuano & Vincenzo Fogliano. (2011) Acrylamide and 5-hydroxymethylfurfural (HMF): A review on metabolism, toxicity, occurrence in food and mitigation strategies. LWT - Food Science and Technology 44:4, pages 793-810.
Crossref
Lisa M. Sweeney, Christopher R. Kirman, Michael L. Gargas, M. Leigh Carson & Robert G. Tardiff. (2010) Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humans. Food and Chemical Toxicology 48:2, pages 668-685.
Crossref
M.L. Gargas, C.R. Kirman, L.M. Sweeney & R.G. Tardiff. (2009) Response to, “Reaction on Gargas et al.: Acrylamide: Consideration of species differences and nonlinear processes in estimating risk and safety for human ingestion”, by Hogervorst et al.. Food and Chemical Toxicology 47:11, pages 2873-2874.
Crossref
Hon‐Wing Leung. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
M.L. Gargas, C.R. Kirman, L.M. Sweeney & R.G. Tardiff. (2009) Acrylamide: Consideration of species differences and nonlinear processes in estimating risk and safety for human ingestion. Food and Chemical Toxicology 47:4, pages 760-768.
Crossref
Nur Duale, Thomas Bjellaas, Jan Alexander, Georg Becher, Margaretha Haugen, Jan Erik Paulsen, Henrik Frandsen, Pelle Thonning Olesen & Gunnar Brunborg. (2009) Biomarkers of Human Exposure to Acrylamide and Relation to Polymorphisms in Metabolizing Genes. Toxicological Sciences 108:1, pages 90-99.
Crossref
Michael Dourson, Richard Hertzberg, Bruce Allen, Lynne Haber, Ann Parker, Oliver Kroner, Andy Maier & Melissa Kohrman. (2008) Evidence-based dose–response assessment for thyroid tumorigenesis from acrylamide. Regulatory Toxicology and Pharmacology 52:3, pages 264-289.
Crossref
Sean M. Hays & Lesa L. Aylward. (2008) Biomonitoring Equivalents (BE) dossier for acrylamide (AA) (CAS No. 79-06-1). Regulatory Toxicology and Pharmacology 51:3, pages S57-S67.
Crossref
Evelyn Lamy, Yvonne Völkel, Peter H. Roos, Fekadu Kassie & Volker Mersch-Sundermann. (2008) Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion. International Journal of Hygiene and Environmental Health 211:1-2, pages 74-81.
Crossref
Thomas Bjellaas, Hege B. A. Ølstørn, Georg Becher, Jan Alexander, Svein H. Knutsen & Jan E. Paulsen. (2007) Urinary Metabolites as Biomarkers of Acrylamide Exposure in Mice Following Dietary Crisp Bread Administration or Subcutaneous Injection. Toxicological Sciences 100:2, pages 374-380.
Crossref
John F. Young, Richard H. Luecke & Daniel R. Doerge. (2007) Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Acrylamide and Its Metabolites in Mice, Rats, and Humans. Chemical Research in Toxicology 20:3, pages 388-399.
Crossref
Michael Bretz, Anja Knecht, Simon Göckler, Hans‐Ulrich Humpf, Isabelle Kölling‐Speer, Alfred Montag, Torsten Kurzrock, Karl Speer, Andreas Kliemant, Hartmut Waldner, Esther Mayer‐Miebach, Diana Behsnilian, Heike P. Schuchmann, Achim Bub, Martina Kasper, Peter Schieberle, Ingrid Halle, Gerhard Flachowsky, Marcus Ihling, Monika Lahrssen‐Wiederholt, Horst Klaffke, Sonja Schittko, Holger Fritz, Robert Gatermann, Ansgar Ruthenschrör, Knut Franke, Ernst H. Reimerdes, Ping Idda, Wolf‐Dietrich Koller, Sonja Muscat, Monika Pischetsrieder, Daniel Bertow, Matthias Baum, Gerhard Eisenbrand, Doris Marko, Zeina Tjaden, Florian Fueller, Nicole Puppel, Nadine Knoll, Anja Weise, Michael Glei, Uwe Claussen, Brigitte Marian & Beatrice L. Pool‐Zobel. 2007. Thermal Processing of Food. Thermal Processing of Food 225 277 .
Hideo Kurebayashi & Yasuo Ohno. (2006) Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: protective effects of GSH precursors. Archives of Toxicology 80:12, pages 820-828.
Crossref
Ivonne M. C. M. Rietjens & Gerrit M. Alink. (2006) Future of ToxicologyLow-Dose Toxicology and Risk−Benefit Analysis. Chemical Research in Toxicology 19:8, pages 977-981.
Crossref
Alan R. Katritzky, Minati Kuanar, Dan C. Fara, Mati Karelson, William E. AcreeJr.Jr., Vitaly P. Solov’ev & Alexandre Varnek. (2005) QSAR modeling of blood:air and tissue:air partition coefficients using theoretical descriptors. Bioorganic & Medicinal Chemistry 13:23, pages 6450-6463.
Crossref
Daniel R. Doerge, John F. Young, L. Patrice McDaniel, Nathan C. Twaddle & Mona I. Churchwell. (2005) Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats. Toxicology and Applied Pharmacology 208:3, pages 199-209.
Crossref
E. Dybing, P.B. Farmer, M. Andersen, T.R. Fennell, S.P.D. Lalljie, D.J.G. Müller, S. Olin, B.J. Petersen, J. Schlatter, G. Scholz, J.A. Scimeca, N. Slimani, M. Törnqvist, S. Tuijtelaars & P. Verger. (2005) Human exposure and internal dose assessments of acrylamide in food. Food and Chemical Toxicology 43:3, pages 365-410.
Crossref
Jeanne Manson, Michael J. Brabec, Judy Buelke-Sam, Gary P. Carlson, Robert E. Chapin, John B. Favor, Lawrence J. Fischer, Dale Hattis, Peter S.J. Lees, Sally Perreault-Darney, Joe Rutledge, Thomas J. Smith, Raymond R. Tice & Peter Working. (2005) NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of acrylamide. Birth Defects Research Part B: Developmental and Reproductive Toxicology 74:1, pages 17-113.
Crossref
Melvin E. Andersen, Joseph Scimeca & Stephen S. Olin. 2005. Chemistry and Safety of Acrylamide in Food. Chemistry and Safety of Acrylamide in Food 117 125 .
Nathan C. Twaddle, L.Patrice McDaniel, Gonçalo Gamboa da Costa, Mona I. Churchwell, Frederick A. Beland & Daniel R. Doerge. (2004) Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS. Cancer Letters 207:1, pages 9-17.
Crossref

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