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Original Articles

Immunomodulatory Effects of in Vitro Exposure to Organochlorines on T-Cell Proliferation in Marine Mammals and Mice

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Pages 283-302 | Received 04 Jan 2005, Accepted 10 Mar 2005, Published online: 24 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Chiharu Mori, Brenda Morsey, Milton Levin, TimothyS. Gorton & Sylvain De Guise. (2008) Effects of Organochlorines, Individually and in Mixtures, on B-Cell Proliferation in Marine Mammals and Mice. Journal of Toxicology and Environmental Health, Part A 71:4, pages 266-275.
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Milton Levin, Brenda Morsey & Sylvain De Guise. (2007) Non-coplanar PCBs Induce Calcium Mobilization in Bottlenose Dolphin and Beluga Whale, but not in Mouse Leukocytes. Journal of Toxicology and Environmental Health, Part A 70:14, pages 1220-1231.
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Milton Levin, Brenda Morsey & Sylvain De Guise. (2006) Modulation of the Respiratory Burst by Organochlorine Mixtures in Marine Mammals, Humans, and Mice. Journal of Toxicology and Environmental Health, Part A 70:1, pages 73-83.
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Articles from other publishers (46)

J. Bjørneset, P. Blévin, P.M. Bjørnstad, R.A. Dalmo, A. Goksøyr, M. Harju, G. Limonta, C. Panti, A.H. Rikardsen, A.Y.M. Sundaram, F. Yadetie & H. Routti. (2023) Establishment of killer whale (Orcinus orca) primary fibroblast cell cultures and their transcriptomic responses to pollutant exposure. Environment International 174, pages 107915.
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Patricia A. Fair & Magali Houde. 2023. Environmental Contaminants and Endocrine Health. Environmental Contaminants and Endocrine Health 283 306 .
Brianne K. Soulen, Lauren M. Divine, Barney J. Venables & Aaron P. Roberts. (2022) Persistent organic pollutant exposure and associations with gene expression in northern fur seals (Callorhinus ursinus) from St. Paul Island, Alaska. Marine Environmental Research 182, pages 105789.
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J.-P. W. Desforges, U. Siebert, H. Routti, M. Levin, R. Dietz, N. Basu, R. J. Letcher, B. M. Jenssen & C. Sonne. 2022. Marsupial and Placental Mammal Species in Environmental Risk Assessment Strategies. Marsupial and Placental Mammal Species in Environmental Risk Assessment Strategies 133 169 .
Gabriella R.M. Leighton, Jacqueline M. Bishop, Pablo R. Camarero, Rafael Mateo, M. Justin O'Riain & Laurel E.K. Serieys. (2022) Poisoned chalice: Use of transformed landscapes associated with increased persistent organic pollutant concentrations and potential immune effects for an adaptable carnivore. Science of The Total Environment 822, pages 153581.
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Sylvain De Guise, Milton Levin, Lindsay Jasperse, Jean Herrman, Randall S. Wells, Teresa Rowles & Lori Schwacke. (2021) Long‐Term Immunological Alterations in Bottlenose Dolphin a Decade after the Deepwater Horizon Oil Spill in the Northern Gulf of Mexico: Potential for Multigenerational Effects . Environmental Toxicology and Chemistry 40:5, pages 1308-1321.
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Jennifer Bourque, Jean-Pierre Desforges, Milton Levin, Todd C. Atwood, Christian Sonne, Rune Dietz, Trine H. Jensen, Erin Curry & Melissa A. McKinney. (2020) Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus). Science of The Total Environment 745, pages 140978.
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Clare Andvik, Eve Jourdain, Anders Ruus, Jan L. Lyche, Richard Karoliussen & Katrine Borgå. (2020) Preying on seals pushes killer whales from Norway above pollution effects thresholds. Scientific Reports 10:1.
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Milton Levin, Lindsay Jasperse, Jean-Pierre Desforges, Todd O'Hara, Lorrie Rea, J. Margaret Castellini, John M. Maniscalco, Brian Fadely & Mandy Keogh. (2020) Methyl mercury (MeHg) in vitro exposure alters mitogen-induced lymphocyte proliferation and cytokine expression in Steller sea lion (Eumetopias jubatus) pups. Science of The Total Environment 725, pages 138308.
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Mandy J. Keogh, Brian Taras, Kimberlee B. Beckmen, Kathleen A. Burek-Huntington, Gina M. Ylitalo, Brian S. Fadely, Lorrie D. Rea & Kenneth W. Pitcher. (2020) Organochlorine contaminant concentrations in blubber of young Steller sea lion (Eumetopias jubatus) are influenced by region, age, sex, and lipid stores. Science of The Total Environment 698, pages 134183.
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Ashley Barratclough, Randall S. Wells, Lori H. Schwacke, Teresa K. Rowles, Forrest M. Gomez, Deborah A. Fauquier, Jay C. Sweeney, Forrest I. Townsend, Larry J. Hansen, Eric S. Zolman, Brian C. Balmer & Cynthia R. Smith. (2019) Health Assessments of Common Bottlenose Dolphins (Tursiops truncatus): Past, Present, and Potential Conservation Applications. Frontiers in Veterinary Science 6.
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Sylvain De Guise, Milton Levin, Lindsay Jasperse, Guillermo Risatti & Randall S. Wells. (2019) T Helper Cell Subsets and Their Functions in Common Bottlenose Dolphins (Tursiops truncatus). Frontiers in Immunology 10.
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Ignacio Peñín, Mónica E. Figueroa-Cabañas, Fabiola Guerrero-de la Rosa, Luis A. Soto-García, Roberto Álvarez-Martínez, Adriana Flores-Morán & Karina Acevedo-Whitehouse. (2019) Transcriptional Profiles of California Sea Lion Peripheral NK and CD+8 T Cells Reflect Ecological Regionalization and Infection by Oncogenic Viruses. Frontiers in Immunology 10.
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I. Peñín, M. Levin, K. Acevedo-Whitehouse, L. Jasperse, E. Gebhard, F.M.D. Gulland & S. De Guise. (2018) Effects of polychlorinated biphenyls (PCB) on California sea lion (Zalophus californianus) lymphocyte functions upon in vitro exposure. Environmental Research 167, pages 708-717.
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Jennifer H. Kopanke, Katherine E. Horak, Esther Musselman, Craig A. Miller, Kristine Bennett, Christine S. Olver, Steven F. Volker, Sue VandeWoude & Sarah N. Bevins. (2018) Effects of Low-level Brodifacoum Exposure on the Feline Immune Response. Scientific Reports 8:1.
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Mahyar Nouri-Shirazi, Brittany F. Bible, Menghua Zeng, Saba Tamjidi & Gregory D. Bossart. (2017) Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Veterinary Research 13:1.
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Sara Pedro, Conor Boba, Rune Dietz, Christian Sonne, Aqqalu Rosing-Asvid, Martin Hansen, Anthony Provatas & Melissa A. McKinney. (2017) Blubber-depth distribution and bioaccumulation of PCBs and organochlorine pesticides in Arctic-invading killer whales. Science of The Total Environment 601-602, pages 237-246.
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Jean-Pierre Desforges, Milton Levin, Lindsay Jasperse, Sylvain De Guise, Igor Eulaers, Robert J. Letcher, Mario Acquarone, Erling Nordøy, Lars P. Folkow, Trine Hammer Jensen, Carsten Grøndahl, Mads F. Bertelsen, Judy St. Leger, Javier Almunia, Christian Sonne & Rune Dietz. (2017) Effects of Polar Bear and Killer Whale Derived Contaminant Cocktails on Marine Mammal Immunity. Environmental Science & Technology 51:19, pages 11431-11439.
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Christine Kleinert, Emilie Lacaze, Méryl Mounier, Sylvain De Guise & Michel Fournier. (2017) Immunotoxic effects of single and combined pharmaceuticals exposure on a harbor seal (Phoca vitulina) B lymphoma cell line. Marine Pollution Bulletin 118:1-2, pages 237-247.
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Y. Oulhote, Z. Shamim, K. Kielsen, P. Weihe, P. Grandjean, L.P. Ryder & C. Heilmann. (2017) Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants. Reproductive Toxicology 68, pages 207-214.
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Milton Levin, Erika Gebhard, Lindsay Jasperse, Jean-Pierre Desforges, Rune Dietz, Christian Sonne, Igor Eulaers, Adrian Covaci, Rossana Bossi & Sylvain De Guise. (2016) Immunomodulatory effects of exposure to polychlorinated biphenyls and perfluoroalkyl acids in East Greenland ringed seals (Pusa hispida). Environmental Research 151, pages 244-250.
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Andrea L. Bogomolni, Anna L. Bass, Spencer Fire, Lindsay Jasperse, Milton Levin, Ole Nielsen, Gordon Waring & Sylvain De Guise. (2016) Saxitoxin increases phocine distemper virus replication upon in-vitro infection in harbor seal immune cells. Harmful Algae 51, pages 89-96.
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Jean-Pierre W. Desforges, Christian Sonne, Milton Levin, Ursula Siebert, Sylvain De Guise & Rune Dietz. (2016) Immunotoxic effects of environmental pollutants in marine mammals. Environment International 86, pages 126-139.
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Liesbeth Weijs & Annalisa Zaccaroni. (2015) Toxicology of Marine Mammals: New Developments and Opportunities. Archives of Environmental Contamination and Toxicology 70:1, pages 1-8.
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Andrea Bogomolni, Salvatore FrascaJrJr, Milton Levin, Keith Matassa, Ole Nielsen, Gordon Waring & Sylvain De Guise. (2015) In Vitro Exposure of Harbor Seal Immune Cells to Aroclor 1260 Alters Phocine Distemper Virus Replication. Archives of Environmental Contamination and Toxicology 70:1, pages 121-132.
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Mandy J. Keogh & Shannon Atkinson. (2015) Endocrine and immunological responses to adrenocorticotrophic hormone (ACTH) administration in juvenile harbor seals ( Phoca vitulina ) during winter and summer. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 188, pages 22-31.
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Erika Gebhard, Milton Levin, Andrea Bogomolni & Sylvain De Guise. (2015) Immunomodulatory effects of brevetoxin (PbTx-3) upon in vitro exposure in bottlenose dolphins (Tursiops truncatus). Harmful Algae 44, pages 54-62.
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Jena R. Wirth, Margie M. Peden-Adams, Natasha D. White, Gregory D. Bossart & Patricia A. Fair. (2015) In vitro exposure of DE-71, a penta-PBDE mixture, on immune endpoints in bottlenose dolphins ( Tursiops truncatus ) and B6C3F1 mice . Journal of Applied Toxicology 35:2, pages 191-198.
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Jena R. Wirth, Margie M. Peden-Adams, Natasha D. White, Gregory D. Bossart & Patricia A. Fair. (2014) In vitro PFOS exposure on immune endpoints in bottlenose dolphins ( Tursiops truncatus ) and mice . Journal of Applied Toxicology 34:6, pages 658-666.
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June T. Spector, Anneclaire J. De Roos, Cornelia M. Ulrich, Lianne Sheppard, Andreas Sjo¨din, Mark H. Wener, Brent Wood & Anne McTiernan. (2014) Plasma polychlorinated biphenyl concentrations and immune function in postmenopausal women. Environmental Research 131, pages 174-180.
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Nadjet Benchalgo, François Gagné & Michel Fournier. (2014) Immunotoxic effects of an industrial waste incineration site on groundwater in rainbow trout (Oncorhynchus mykiss). Journal of Environmental Sciences 26:5, pages 981-990.
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Richard F. Lee, Karrie Bulski, Jeffrey D. Adams, Margie Peden-Adams, Gregory D. Bossart, Lydia King & Patricia A. Fair. (2013) DNA strand breaks (comet assay) in blood lymphocytes from wild bottlenose dolphins. Marine Pollution Bulletin 77:1-2, pages 355-360.
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Aurélie Dupont, Ursula Siebert, Adrian Covaci, Liesbeth Weijs, Gauthier Eppe, Cathy Debier, Marie-Claire De Pauw-Gillet & Krishna Das. (2013) Relationships between in vitro lymphoproliferative responses and levels of contaminants in blood of free-ranging adult harbour seals (Phoca vitulina) from the North Sea. Aquatic Toxicology 142-143, pages 210-220.
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Lori H. Schwacke, Eric S. Zolman, Brian C. Balmer, Sylvain De Guise, R. Clay George, Jennifer Hoguet, Aleta A. Hohn, John R. Kucklick, Steve Lamb, Milton Levin, Jenny A. Litz, Wayne E. McFee, Ned J. Place, Forrest I. Townsend, Randall S. Wells & Teresa K. Rowles. (2011) Anaemia, hypothyroidism and immune suppression associated with polychlorinated biphenyl exposure in bottlenose dolphins ( Tursiops truncatus ) . Proceedings of the Royal Society B: Biological Sciences 279:1726, pages 48-57.
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Mandy J. Keogh, John M. Maniscalco & Shannon Atkinson. (2010) Steller sea lion (Eumetopias jubatus) pups undergo a decrease in circulating white blood cells and the ability of T cells to proliferate during early postnatal development. Veterinary Immunology and Immunopathology 137:3-4, pages 298-304.
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Robert J. Letcher, Jan Ove Bustnes, Rune Dietz, Bjørn M. Jenssen, Even H. Jørgensen, Christian Sonne, Jonathan Verreault, Mathilakath M. Vijayan & Geir W. Gabrielsen. (2010) Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish. Science of The Total Environment 408:15, pages 2995-3043.
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Catherine J. Walsh, Stephanie R. Leggett, Barbara J. Carter & Clarence Colle. (2010) Effects of brevetoxin exposure on the immune system of loggerhead sea turtles. Aquatic Toxicology 97:4, pages 293-303.
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Jennifer E. Yordy, Randall S. Wells, Brian C. Balmer, Lori H. Schwacke, Teri K. Rowles & John R. Kucklick. (2010) Life history as a source of variation for persistent organic pollutant (POP) patterns in a community of common bottlenose dolphins (Tursiops truncatus) resident to Sarasota Bay, FL. Science of The Total Environment 408:9, pages 2163-2172.
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Andreas Beineke, Ursula Siebert, Peter Wohlsein & Wolfgang Baumgärtner. (2010) Immunology of whales and dolphins. Veterinary Immunology and Immunopathology 133:2-4, pages 81-94.
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Milton Levin, Heather Leibrecht, James Ryan, Frances Van Dolah & Sylvain De Guise. (2008) Immunomodulatory Effects of Domoic Acid Differ Between In vivo and In vitro Exposure in Mice. Marine Drugs 6:4, pages 636-659.
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Héloïse Frouin, Michel Lebeuf, Richard Saint-Louis, Mike Hammill, Émilien Pelletier & Michel Fournier. (2008) Toxic effects of tributyltin and its metabolites on harbour seal (Phoca vitulina) immune cells in vitro. Aquatic Toxicology 90:3, pages 243-251.
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S. Cámara Pellissó, M.J. Muñoz, M. Carballo & J.M. Sánchez-Vizcaíno. (2008) Determination of the immunotoxic potential of heavy metals on the functional activity of bottlenose dolphin leukocytes in vitro. Veterinary Immunology and Immunopathology 121:3-4, pages 189-198.
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Margaret M. Krahn, M. Bradley Hanson, Robin W. Baird, Richard H. Boyer, Douglas G. Burrows, Candice K. Emmons, John K.B. Ford, Linda L. Jones, Dawn P. Noren, Peter S. Ross, Gregory S. Schorr & Tracy K. Collier. (2007) Persistent organic pollutants and stable isotopes in biopsy samples (2004/2006) from Southern Resident killer whales. Marine Pollution Bulletin 54:12, pages 1903-1911.
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Milton Levin, Heather Leibrecht, Chiharu Mori, David Jessup & Sylvain De Guise. (2007) Immunomodulatory effects of organochlorine mixtures upon in vitro exposure of peripheral blood leukocytes differ between free-ranging and captive southern sea otters (Enhydra lutris). Veterinary Immunology and Immunopathology 119:3-4, pages 269-277.
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Lizzy Mos, Brenda Morsey, Steven J. Jeffries, Mark B. Yunker, Stephen Raverty, Sylvain De Guise & Peter S. Ross. (2009) Chemical and biological pollution contribute to the immunological profiles of free‐ranging harbor seals. Environmental Toxicology and Chemistry 25:12, pages 3110-3117.
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David Santillo & Paul Johnston. (2006) Effect thresholds and ‘Adequate Control’ of risks. Environmental Science and Pollution Research 13:6, pages 425-431.
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