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Journal of Toxicology and Environmental Health, Part A
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Volume 69, 2006 - Issue 5
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Original Articles

Effects of Di(2-Ethylhexyl) Phthalate, A Widely Used Peroxisome Proliferator and Plasticizer, on Cell Growth in the Human Keratinocyte Cell Line NCTC 2544

Germana Martinasso Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Torino, Italy
,
Marina Maggiora Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Torino, Italy
,
Antonella Trombetta Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Torino, Italy
,
Rosa Angela Canuto Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Torino, ItalyCorrespondence[email protected]
&
Giuliana Muzio Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Torino, Italy
Pages 353-365 | Received 17 Dec 2004, Accepted 10 Mar 2005, Published online: 20 Aug 2006

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Ju Young Ryu, Jung Whang, Hyeyoung Park, Ji Young Im, Jeonga Kim, Mee Young Ahn, Jaewon Lee, Hyung Sik Kim, Byung Mu Lee, Sun Dong Yoo, Seung Jun Kwack, Jae Ho Oh, Kui Lea Park, Soon Young Han & Seung Hee Kim. (2007) Di(2-ethylhexyl) Phthalate Induces Apoptosis Through Peroxisome Proliferators-Activated Receptor-Gamma and ERK 1/2 Activation in Testis of Sprague-Dawley Rats. Journal of Toxicology and Environmental Health, Part A 70:15-16, pages 1296-1303.
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Articles from other publishers (28)

Yuxin Qian, Lijian Zhu, Jingya Chen, Yilin Zhou, Zhiguang Huang, Linjie Liang & Bin Ding. (2023) Di-(2-ethylhexyl) phthalate aggravates psoriasis-like skin lesions: In vitro and in vivo evaluation. Toxicology and Applied Pharmacology 479, pages 116707.
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Roya Pournejati, Ronald Gust, Jessica Sagasser, Brigitte Kircher, Karin Jöhrer, Mohammad Mehdi Ghanbari & Hamid Reza Karbalaei-Heidari. (2021) In vitro evaluation of cytotoxic effects of di (2-ethylhexyl) phthalate (DEHP) produced by Bacillus velezensis strain RP137 isolated from Persian Gulf. Toxicology in Vitro 73, pages 105148.
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Chiara Molino, Silvia Filippi, Gerardo Antonio Stoppiello, Roberta Meschini & Dario Angeletti. (2019) In vitro evaluation of cytotoxic and genotoxic effects of Di(2-ethylhexyl)-phthalate (DEHP) on European sea bass (Dicentrarchus labrax) embryonic cell line. Toxicology in Vitro 56, pages 118-125.
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Jin Hee Kim. (2019) Di(2-ethylhexyl) phthalate promotes lung cancer cell line A549 progression via Wnt/β-catenin signaling. The Journal of Toxicological Sciences 44:4, pages 237-244.
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Jin Kim. (2018) Analysis of the in�vitro effects of di‑(2‑ethylhexyl) phthalate exposure on human uterine leiomyoma cells. Experimental and Therapeutic Medicine.
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Mehdi Goudarzi, Mahdi Esmaeilizadeh, Mojtaba Dolatshahi, Hadi Kalantar, Hossein Frouzandeh & Mojtaba Kalantar. (2017) Protective Effect of Elaeagnus angustifolia L. Fruit Hydroalcoholic Extract on Cyclophosphamide-Induced Nephrotoxicity in Mice. Shiraz E-Medical Journal In Press:In Press.
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Ning Wei, Xiaoyan Feng, Zhiqin Xie, Yanan Zhang & Ying Feng. (2017) Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFκB. Toxicology in Vitro 42, pages 86-92.
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Ana Peropadre, Paloma Fernández Freire, José Manuel Pérez Martín, Óscar Herrero & María José Hazen. (2015) Endoplasmic reticulum stress as a novel cellular response to di (2-ethylhexyl) phthalate exposure. Toxicology in Vitro 30:1, pages 281-287.
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A.C.S. Lourenço, V. Galbiati, D. Corti, A. Papale, A.J. Martino-Andrade & E. Corsini. (2015) The plasticizer dibutyl phthalate (DBP) potentiates chemical allergen-induced THP-1 activation. Toxicology in Vitro 29:8, pages 2001-2008.
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Xuan Wang, Lijie Jiang, Lan Ge, Min Chen, Guang Yang, Fang Ji, Laifu Zhong, Yingjie Guan & Xiaofang Liu. (2015) Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line. Environmental Toxicology and Pharmacology 39:3, pages 1099-1106.
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Jaap G. Neels & Paul A. Grimaldi. (2014) Physiological Functions of Peroxisome Proliferator-Activated Receptor β. Physiological Reviews 94:3, pages 795-858.
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Manuela Oraldi, Marina Maggiora, Elena Paiuzzi, Rosa A. Canuto & Giuliana Muzio. (2012) CLA Reduces Inflammatory Mediators from A427 Human Lung Cancer Cells and A427 Conditioned Medium Promotes Differentiation of C2C12 Murine Muscle Cells. Lipids 48:1, pages 29-38.
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Jane C. Caldwell. (2012) DEHP: Genotoxicity and potential carcinogenic mechanisms—A review. Mutation Research/Reviews in Mutation Research 751:2, pages 82-157.
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Ivan Rusyn & J. Christopher Corton. (2012) Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutation Research/Reviews in Mutation Research 750:2, pages 141-158.
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Jeffrey M. Peters & Frank J. Gonzalez. 2011. Signaling Pathways in Squamous Cancer. Signaling Pathways in Squamous Cancer 223 240 .
Karine Audouze, Agnieszka Sierakowska Juncker, Francisco J. S. S. A. Roque, Konrad Krysiak-Baltyn, Nils Weinhold, Olivier Taboureau, Thomas Skøt Jensen & Søren Brunak. (2010) Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks. PLoS Computational Biology 6:5, pages e1000788.
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Jeffrey M. Peters & Frank J. Gonzalez. (2009) Sorting out the functional role(s) of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1796:2, pages 230-241.
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Michael G. Borland, Jennifer E. Foreman, Elizabeth E. Girroir, Reza Zolfaghari, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, A. Catharine Ross & Jeffrey M. Peters. (2008) Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/δ Inhibits Cell Proliferation in Human HaCaT Keratinocytes. Molecular Pharmacology 74:5, pages 1429-1442.
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Weiwei Shan, Prajakta S. Palkar, Iain A. Murray, Emily I. McDevitt, Mary J. Kennett, Boo Hyon Kang, Harriet C. Isom, Gary H. Perdew, Frank J. Gonzalez & Jeffrey M. Peters. (2008) Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression. Toxicological Sciences 105:2, pages 418-428.
Crossref
Jeffrey M. PetersHolly E. HollingsheadFrank J. Gonzalez. (2008) Role of peroxisome-proliferator-activated receptor β/δ (PPARβ/δ) in gastrointestinal tract function and disease. Clinical Science 115:4, pages 107-127.
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Matthias Schmuth, Yan J. Jiang, Sandrine Dubrac, Peter M. Elias & Kenneth R. Feingold. (2008) Thematic Review Series: Skin Lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology. Journal of Lipid Research 49:3, pages 499-509.
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Giuseppina Barrera, Cristina Toaldo, Stefania Pizzimenti, Angelo Cerbone, Piergiorgio Pettazzoni, Mario Umberto Dianzani & Carlo Ferretti. (2008) The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products. PPAR Research 2008, pages 1-15.
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Holly E. Hollingshead, Michael G. Borland, Andrew N. Billin, Timothy M. Willson, Frank J. Gonzalez & Jeffrey M. Peters. (2008) Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. Carcinogenesis 29:1, pages 169-176.
Crossref
Elizabeth E. Girroir, Holly E. Hollingshead, Andrew N. Billin, Timothy M. Willson, Gavin P. Robertson, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez & Jeffrey M. Peters. (2008) Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. Toxicology 243:1-2, pages 236-243.
Crossref
Weiwei Shan, Christopher J. Nicol, Shinji Ito, Moses T. Bility, Mary J. Kennett, Jerrold M. Ward, Frank J. Gonzalez & Jeffrey M. Peters. (2007) Peroxisome proliferator-activated receptor-β/δ protects against chemically induced liver toxicity in mice. Hepatology 47:1, pages 225-235.
Crossref
Holly E. Hollingshead, Renee L. Killins, Michael G. Borland, Elizabeth E. Girroir, Andrew N. Billin, Timothy M. Willson, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez & Jeffrey M. Peters. (2007) Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis 28:12, pages 2641-2649.
Crossref
Andrew D. Burdick, Moses T. Bility, Elizabeth E. Girroir, Andrew N. Billin, Timothy M. Willson, Frank J. Gonzalez & Jeffrey M. Peters. (2007) Ligand activation of peroxisome proliferator-activated receptor-β/δ(PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes. Cellular Signalling 19:6, pages 1163-1171.
Crossref
G. Martinasso, M. Oraldi, A. Trombetta, M. Maggiora, O. Bertetto, R. A. Canuto & G. Muzio. (2007) Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PPAR Research 2007, pages 1-9.
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