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Original Articles

Silica-Induced Apoptosis in Alveolar Macrophages: Evidence of in Vivo Thiol Depletion and the Activation of Mitochondrial Pathway

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Pages 1261-1284 | Published online: 17 Aug 2006

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Rajendran Sellamuthu, Christina Umbright, Jenny R. Roberts, Shih-Houng Young, Diana Richardson, Walter McKinney, Bean T. Chen, Shengqiao Li, Michael Kashon & Pius Joseph. (2017) Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats. Inhalation Toxicology 29:2, pages 53-64.
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Shi Chen, Juxiang Yuan, Sanqiao Yao, Yulan Jin, Gang Chen, Wei Tian, Jinkun Xi, Zhelong Xu, Dong Weng & Jie Chen. (2015) Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis. Autophagy 11:12, pages 2346-2357.
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Hajime Kawasaki. (2015) A mechanistic review of silica-induced inhalation toxicity. Inhalation Toxicology 27:8, pages 363-377.
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Jean C. Pfau, Todd Seib, Jason J. Overocker, Jeremy Roe & Aaron S. Ferro. (2012) Functional expression of system xc− is upregulated by asbestos but not crystalline silica in murine macrophages. Inhalation Toxicology 24:8, pages 476-485.
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Rajendran Sellamuthu, Christina Umbright, Shengqiao Li, Michael Kashon & Pius Joseph. (2011) Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. Inhalation Toxicology 23:14, pages 927-937.
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Chunhui Ni, Yang Ye, Meilin Wang, Haiyang Qian, Zhifang Song, Xiaomin Jia & Jianwei Zhou. (2009) A Six-Nucleotide Insertion-Deletion Polymorphism in the CASP8 Promoter is Associated with Risk of Coal Workers' Pneumoconiosis. Journal of Toxicology and Environmental Health, Part A 72:11-12, pages 712-716.
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Shuiying Hu, Hongwen Zhao, XuejunJ. Yin & JosephK. H. Ma. (2007) Role of Mitochondria in Silica-Induced Apoptosis of Alveolar Macrophages: Inhibition of Apoptosis by Rhodamine 6g and -acetyl-L-cysteine. Journal of Toxicology and Environmental Health, Part A 70:17, pages 1403-1415.
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Xinrong Tian, Yu Wei, Runsu Hou, Xinguang Liu, Yange Tian, Peng Zhao & Jiansheng Li. (2023) Yangqing Chenfei formula alleviates silica-induced pulmonary inflammation in rats by inhibiting macrophage M1 polarization. Chinese Medicine 18:1.
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Shiyi Tan, Shang Yang, Huimin Kang, Ke Zhou, Hanqin Wang, Yujing Zhang & Shi Chen. (2023) Atractylenolide III Ameliorated Autophagy Dysfunction via Epidermal Growth Factor Receptor-Mammalian Target of Rapamycin Signals and Alleviated Silicosis Fibrosis in Mice. Laboratory Investigation 103:2, pages 100024.
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Shiyi Tan & Shi Chen. (2021) The Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis. International Journal of Molecular Sciences 22:15, pages 8110.
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Shiyi Tan & Shi Chen. (2021) Macrophage Autophagy and Silicosis: Current Perspective and Latest Insights. International Journal of Molecular Sciences 22:1, pages 453.
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Hantae Jo, Jeong-Hyun Oh, Dong-Wook Park, Changho Lee & Churl K. Min. (2020) Oleanolic acid 3-acetate, a minor element of ginsenosides, induces apoptotic cell death in ovarian carcinoma and endometrial carcinoma cells via the involvement of a reactive oxygen species–independent mitochondrial pathway. Journal of Ginseng Research 44:1, pages 96-104.
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Licong Yang, Jingnan Zhang, Chuan Wang, Xiuying Qin, Qianqian Yu, Yanhui Zhou & Jie Liu. (2014) Interaction between 8-hydroxyquinoline ruthenium( ii ) complexes and basic fibroblast growth factors (bFGF): inhibiting angiogenesis and tumor growth through ERK and AKT signaling pathways . Metallomics 6:3, pages 518-531.
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Leslie Chávez-Galán, Lucero A. Ramon-Luing, Luis Torre-Bouscoulet, Rogelio Pérez-Padilla & Isabel Sada-Ovalle. (2013) Pre-Exposure of Mycobacterium tuberculosis-Infected Macrophages to Crystalline Silica Impairs Control of Bacterial Growth by Deregulating the Balance between Apoptosis and Necrosis. PLoS ONE 8:11, pages e80971.
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Gaurav N. Joshi & David A. Knecht. (2013) Silica phagocytosis causes apoptosis and necrosis by different temporal and molecular pathways in alveolar macrophages. Apoptosis 18:3, pages 271-285.
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Magdiel Inggrid Setyawati, Wanru Fang, Sing Ling Chia & David Tai Leong. (2012) Nanotoxicology of common metal oxide based nanomaterials: their ROS‐y and non‐ROS‐y consequences. Asia-Pacific Journal of Chemical Engineering 8:2, pages 205-217.
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Vasanthi R. Sunil, Kinal Patel-Vayas, Jianliang Shen, Jeffrey D. Laskin & Debra L. Laskin. (2012) Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicology and Applied Pharmacology 263:2, pages 195-202.
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Anne M. FitzpatrickDean P. JonesLou Ann S. Brown. (2012) Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities. Antioxidants & Redox Signaling 17:2, pages 375-408.
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Anne M Fitzpatrick, W Gerald Teague, Leandrea Burwell, Meredith S Brown & Lou Ann S Brown. (2011) Glutathione Oxidation Is Associated With Airway Macrophage Functional Impairment in Children With Severe Asthma. Pediatric Research 69:2, pages 154-159.
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Glinda Cooper, Kathleen Gilbert, Eric Greidinger, Judith James, Jean Pfau, Leslie Reinlib, Bruce Richardson & Noel Rose. (2009) Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Ciência & Saúde Coletiva 14:5, pages 1865-1876.
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You‐Cheng Hseu, Elong Lin, Jing‐Yi Chen, Yi‐Ru Liua, Chun‐Yin Huang, Fung‐Jou Lu, Jiunn‐Wang Liao, Ssu‐Ching Chen & Hsin‐Ling Yang. (2008) Humic acid induces G1 phase arrest and apoptosis in cultured vascular smooth muscle cells. Environmental Toxicology 24:3, pages 243-258.
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Renée M. Gilberti, Gaurav N. Joshi & David A. Knecht. (2008) The Phagocytosis of Crystalline Silica Particles by Macrophages. American Journal of Respiratory Cell and Molecular Biology 39:5, pages 619-627.
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Hsin-Ling Yang, Ssu-Ching Chen, Chih-Sheng Chen, Sheng-Yang Wang & You-Cheng Hseu. (2008) Alpinia pricei rhizome extracts induce apoptosis of human carcinoma KB cells via a mitochondria-dependent apoptotic pathway. Food and Chemical Toxicology 46:10, pages 3318-3324.
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Glinda S. Cooper, Kathleen M. Gilbert, Eric L. Greidinger, Judith A. James, Jean C. Pfau, Leslie Reinlib, Bruce C. Richardson & Noel R. Rose. (2008) Recent Advances and Opportunities in Research on Lupus: Environmental Influences and Mechanisms of Disease. Environmental Health Perspectives 116:6, pages 695-702.
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Ferdinando Mannello, Jose E. Tanus-Santos, Cesar A. Meschiari & Gaetana A. Tonti. (2008) Differences in both matrix metalloproteinase 9 concentration and zymographic profile between plasma and serum with clot activators are due to the presence of amorphous silica or silicate salts in blood collection devices. Analytical Biochemistry 374:1, pages 56-63.
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Xiao-hong Wang, Dian-zeng Jia, Yong-ju Liang, Su-li Yan, Yan Ding, Li-ming Chen, Zhi Shi, Mu-sheng Zeng, Guang-fei Liu & Li-wu Fu. (2007) Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway. Cancer Letters 249:2, pages 256-270.
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