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Original Articles

Ring-Oxidized Metabolites of Styrene Contribute to Styrene-Induced Clara-Cell Toxicity in Mice

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Pages 229-237 | Received 03 May 2004, Accepted 28 Jun 2004, Published online: 14 Mar 2011

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Read on this site (4)

LorenzR. Rhomberg, JulieE. Goodman & RobynL. Prueitt. (2013) The Weight of Evidence Does Not Support the Listing of Styrene as “Reasonably Anticipated to be a Human Carcinogen” in NTP's Twelfth Report on Carcinogens . Human and Ecological Risk Assessment: An International Journal 19:1, pages 4-27.
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Gary P. Carlson. (2010) Metabolism and Toxicity of Styrene in Microsomal Epoxide Hydrolase-Deficient Mice. Journal of Toxicology and Environmental Health, Part A 73:24, pages 1689-1699.
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Pavel Vodicka, Mikko Koskinen, Alessio Naccarati, Barbara Oesch-Bartlomowicz, Ludmila Vodickova, Kari Hemminki & Franz Oesch. (2006) Styrene Metabolism, Genotoxicity, and Potential Carcinogenicity. Drug Metabolism Reviews 38:4, pages 805-853.
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Articles from other publishers (16)

F. Oesch, E. Fabian & Robert Landsiedel. (2019) Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models. Archives of Toxicology 93:12, pages 3419-3489.
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George Cruzan, James S. Bus, Melvin E. Andersen, Gary P. Carlson, Marcy I. Banton, Satinder S. Sarang & Robbie Waites. (2018) Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern. Regulatory Toxicology and Pharmacology 95, pages 17-28.
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Melvin E. Andersen, George Cruzan, Michael B. Black, Salil N. Pendse, Darol Dodd, James S. Bus, Satinder S. Sarang, Marcy I. Banton, Robbie Waites & Patrick D. McMullen. (2017) Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures. Toxicology and Applied Pharmacology 335, pages 28-40.
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George Cruzan, James S. Bus, Marcy I. Banton, Satinder S. Sarang, Robbie Waites, Debra B. Layko, James Raymond, Darol DoddMelvin E. Andersen. (2017) Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance. Toxicological Sciences 159:2, pages 413-421.
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G. Cruzan, J. Bus, J. Hotchkiss, R. Sura, C. Moore, G. Yost, M. Banton & S. Sarang. (2013) Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors. Regulatory Toxicology and Pharmacology 66:1, pages 24-29.
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R. Garnier. (2012) Cytolyse hépatique et exposition au styrène. Archives des Maladies Professionnelles et de l'Environnement 73:6, pages 935-936.
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Gary P. Carlson. (2012) Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice. Toxicology 294:2-3, pages 104-108.
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G. Cruzan, J. Bus, J. Hotchkiss, J. Harkema, M. Banton & S. Sarang. (2012) CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors. Regulatory Toxicology and Pharmacology 62:1, pages 214-220.
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Moiz M. Mumtaz & Hana R. Pohl. 2012. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 361 379 .
Bing Wu, Jie Sun, Shu-Pei Cheng, Ji-Dong Gu, Ai-Min Li & Xu-Xiang Zhang. (2011) Comparative analysis of binding affinities between styrene and mammalian CYP2E1 by bioinformatics approaches. Ecotoxicology 20:5, pages 1041-1046.
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George Cruzan, James Bus, Marcy Banton, Ralph Gingell & Gary Carlson. (2009) Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: An endpoint/toxic response where data from multiple chemicals converge to support a mode of action. Regulatory Toxicology and Pharmacology 55:2, pages 205-218.
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Jill A. Harvilchuck, Xinzhu Pu, James E. Klaunig & Gary P. Carlson. (2009) Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolites. Toxicology 264:3, pages 171-178.
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Peter Kovacic & Ratnasamy Somanathan. 2009. Reviews of Environmental Contamination and Toxicology Vol 201. Reviews of Environmental Contamination and Toxicology Vol 201 41 69 .
Jill A. Harvilchuck & Gary P. Carlson. (2006) Comparison of styrene and its metabolites styrene oxide and 4-vinylphenol on cytotoxicity and glutathione depletion in Clara cells of mice and rats. Toxicology 227:1-2, pages 165-172.
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Jou-Ku Chung, Wei Yuan, Guangxian Liu & Jiang Zheng. (2006) Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells. Toxicology 226:2-3, pages 99-106.
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Ulrike Luderer, Thomas F.X. Collins, George P. Daston, Lawrence J. Fischer, Ronald H. Gray, Franklin E. Mirer, Andrew F. Olshan, R. Woodrow Setzer, Kimberley A. Treinen & Roel Vermeulen. (2005) NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene. Birth Defects Research Part B: Developmental and Reproductive Toxicology 77:2, pages 110-193.
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