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Original Articles

Neurodegeneration Produced by Rotenone in the Mouse Retina: A Potential Model to Investigate Environmental Pesticide Contributions to Neurodegenerative Diseases

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Pages 1681-1697 | Received 13 Jul 2005, Accepted 16 Sep 2005, Published online: 24 Feb 2007

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Nelzi Ferreira Queiroz Junior, Jovani Antônio Steffani, Larissa Machado, Pâmela Jéssyca Hoss Longhi, Marco Aurélio Echart Montano, Mathias Martins, Sérgio Abreu Machado, Alencar Kolinski Machado & Francine Carla Cadoná. (2021) Antioxidant and cytoprotective effects of avocado oil and extract (Persea americana Mill) against rotenone using monkey kidney epithelial cells (Vero). Journal of Toxicology and Environmental Health, Part A 84:21, pages 875-890.
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Julio C Rojas & Francisco Gonzalez-Lima. (2010) Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies. Eye and Brain 2, pages 21-37.
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C. R. Hayworth, J. C. Rojas & F. Gonzalez-Lima. (2008) Transgenic Mice Expressing Cyan Fluorescent Protein as a Reporter Strain to Detect the Effects of Rotenone Toxicity on Retinal Ganglion Cells. Journal of Toxicology and Environmental Health, Part A 71:24, pages 1582-1592.
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Articles from other publishers (29)

Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte & Pete A. Williams. (2023) Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection. Acta Neuropathologica Communications 11:1.
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Naomi Chadderton, Arpad Palfi, Daniel M. Maloney, Matthew Carrigan, Laura K. Finnegan, Killian S. Hanlon, Ciara Shortall, Mary O’Reilly, Peter Humphries, Lorraine Cassidy, Paul F. Kenna, Sophia Millington-Ward & G. Jane Farrar. (2023) Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction. Pharmaceutics 15:2, pages 322.
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Maki Inoue-Yanagimachi, Noriko Himori, Keiko Uchida, Hiroshi Tawarayama, Kota Sato, Masayuki Yamamoto, Kazuhiko Namekata, Takayuki Harada & Toru Nakazawa. (2023) Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice. Experimental Eye Research 226, pages 109314.
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Sudha Sharma, Foram Patel, Hosne Ara, Ezra Bess, Alika Shum, Susmita Bhattarai, Utsab Subedi, Daquonte Sanard Bell, Md. Shenuarin Bhuiyan, Hong Sun, Ines Batinic-Haberle, Manikandan Panchatcharam & Sumitra Miriyala. (2022) Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux. International Journal of Molecular Sciences 23:9, pages 4675.
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Vahid Shafiei-Irannejad, Samin Abbaszadeh, Paul M.L. Janssen & Hamid Soraya. (2021) Memantine and its benefits for cancer, cardiovascular and neurological disorders. European Journal of Pharmacology 910, pages 174455.
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James R. Tribble, Amin Otmani, Shanshan Sun, Sevannah A. Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Jöe, Emma Lardner, Abinaya P. Venkataraman, Alberto Domínguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Jóhannesson, Robert W. Burgess, Peter G. Fuerst, Rune Brautaset, Miriam Kolko, James E. Morgan, Jonathan G. Crowston, Marcela Votruba & Pete A. Williams. (2021) Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction. Redox Biology 43, pages 101988.
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Hiroshi Tawarayama, Maki Inoue-Yanagimachi, Noriko Himori & Toru Nakazawa. (2021) Glial cells modulate retinal cell survival in rotenone-induced neural degeneration. Scientific Reports 11:1.
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Masaaki Sasaoka, Takashi Ota & Masaaki Kageyama. (2020) Rotenone-induced inner retinal degeneration via presynaptic activation of voltage-dependent sodium and L-type calcium channels in rats. Scientific Reports 10:1.
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Hossein Bagheri, Faezeh Ghasemi, George E. Barreto, Rouhullah Rafiee, Thozhukat Sathyapalan & Amirhossein Sahebkar. (2019) Effects of curcumin on mitochondria in neurodegenerative diseases. BioFactors 46:1, pages 5-20.
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Wenyi Liu, Xue Li, Xi Chen, Jieqiong Zhang, Linlin Luo, Qiumei Hu, Jiaxing Zhou, Jun Yan, Sen Lin & Jian Ye. (2019) JIP1 Deficiency Protects Retinal Ganglion Cells From Apoptosis in a Rotenone-Induced Injury Model. Frontiers in Cell and Developmental Biology 7.
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Kathryn Cimdins, Hayley S. Waugh, Vicki Chrysostomou, M. Isabel G. Lopez Sanchez, Vanessa A. Johannsen, Mark J. Cook, Jonathan G. Crowston, Andrew F. Hill, James A. Duce, Ashley I. Bush & Ian A. Trounce. (2019) Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. Molecular Neurobiology 56:8, pages 5471-5482.
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Lien Veys, Marjan Vandenabeele, Isabel Ortuño-Lizarán, Veerle Baekelandt, Nicolás Cuenca, Lieve Moons & Lies De Groef. (2019) Retinal α-synuclein deposits in Parkinson’s disease patients and animal models. Acta Neuropathologica 137:3, pages 379-395.
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Md. Jakaria, Shin-Young Park, Md. Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan & Dong-Kug Choi. (2018) Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors. Frontiers in Molecular Neuroscience 11.
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E.V. Paravani, M.F. Simoniello, G.L. Poletta, F.R. Zolessi & V.H. Casco. (2018) Cypermethrin: Oxidative stress and genotoxicity in retinal cells of the adult zebrafish. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 826, pages 25-32.
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Birgitte Georg, Anna Ghelli, Carla Giordano, Fred N. Ross-Cisneros, Alfredo A. Sadun, Valerio Carelli, Jens Hannibal & Chiara La Morgia. (2017) Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always. Mitochondrion 36, pages 77-84.
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Martha P. Montgomery, Eric Postel, David M. Umbach, Marie Richards, Mary Watson, Aaron Blair, Honglei Chen, Dale P. Sandler, Silke Schmidt & Freya Kamel. (2017) Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study. Environmental Health Perspectives 125:7.
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Luminita Marutescu & Mariana Carmen Chifiriuc. 2017. New Pesticides and Soil Sensors. New Pesticides and Soil Sensors 393 435 .
Eduardo Maria Normando, Benjamin Michael Davis, Lies De Groef, Shereen Nizari, Lisa A. Turner, Nivedita Ravindran, Milena Pahlitzsch, Jonathan Brenton, Giulia Malaguarnera, Li Guo, Satyanarayana Somavarapu & Maria Francesca Cordeiro. (2016) The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson’s disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain. Acta Neuropathologica Communications 4:1.
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Fiona C Mansergh, Naomi Chadderton, Paul F Kenna, Oliviero L Gobbo & G Jane Farrar. (2014) Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy. European Journal of Human Genetics 22:11, pages 1314-1320.
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Manuel Carloni, Cinzia Nasuti, Donatella Fedeli, Maura Montani, M.S Dhivya Vadhana, Augusto Amici & Rosita Gabbianelli. (2013) Early life permethrin exposure induces long-term brain changes in Nurr1, NF-kB and Nrf-2. Brain Research 1515, pages 19-28.
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Naomi Chadderton, Arpad Palfi, Sophia Millington-Ward, Oliverio Gobbo, Nora Overlack, Matthew Carrigan, Mary O'Reilly, Matthew Campbell, Carsten Ehrhardt, Uwe Wolfrum, Peter Humphries, Paul F Kenna & G Jane Farrar. (2012) Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy. European Journal of Human Genetics 21:1, pages 62-68.
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Manuel Carloni, Cinzia Nasuti, Donatella Fedeli, Maura Montani, Augusto Amici, M.S. Dhivya Vadhana & Rosita Gabbianelli. (2012) The impact of early life permethrin exposure on development of neurodegeneration in adulthood. Experimental Gerontology 47:1, pages 60-66.
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Chiara La Morgia, Fred N. Ross-Cisneros, Jens Hannibal, Pasquale Montagna, Alfredo A. Sadun & Valerio Carelli. (2011) Melanopsin-expressing retinal ganglion cells: implications for human diseases. Vision Research 51:2, pages 296-302.
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C. Santano, M. Pérez de Lara & J. Pintor. 2011. Studies on Experimental Models. Studies on Experimental Models 221 250 .
Ling Dong, Man-Jiang Xie, Peng Zhang, Le-Le Ji, Wen-Chong Liu, Ming-Qing Dong & Feng Gao. (2009) Rotenone partially reverses decreased BK Ca currents in cerebral artery smooth muscle cells from streptozotocin-induced diabetic mice . Clinical and Experimental Pharmacology and Physiology 36:10, pages e57-e64.
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Julio C. Rojas, Joseph M. John, Jung Lee & F. Gonzalez-Lima. (2009) Methylene Blue Provides Behavioral and Metabolic Neuroprotection Against Optic Neuropathy. Neurotoxicity Research 15:3, pages 260-273.
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Julio C. Rojas, Jung Lee, Joseph M. John & F. Gonzalez-Lima. (2008) Neuroprotective Effects of Near-Infrared Light in an In Vivo Model of Mitochondrial Optic Neuropathy . The Journal of Neuroscience 28:50, pages 13511-13521.
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Julio C. Rojas, Jose A. Saavedra & F. Gonzalez-Lima. (2008) Neuroprotective effects of memantine in a mouse model of retinal degeneration induced by rotenone. Brain Research 1215, pages 208-217.
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S. Samantaray, V.H. Knaryan, M.K. Guyton, D.D. Matzelle, S.K. Ray & N.L. Banik. (2007) The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats. Neuroscience 146:2, pages 741-755.
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