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Journal of Toxicology and Environmental Health, Part A
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Volume 69, 2006 - Issue 23
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Original Articles

Development of Physiologically Based Toxicokinetic Models for Improving the Human Indoor Exposure Assessment to Water Contaminants: Trichloroethylene and TrihalomethanesFootnote

Sami HaddadDépartement des sciences biologiques, TOXEN, Université du Québec à Montréal, Montréal, Canada
,
Ginette-Charest TardifGroupe de recherche interdisciplinaire en santé, Départment de santé environnementale et santé au travail, Université de Montréal, Montréal, Canada
&
Robert TardifGroupe de recherche interdisciplinaire en santé, Départment de santé environnementale et santé au travail, Université de Montréal, Montréal, Canada
Pages 2095-2136 | Published online: 24 Feb 2007

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Pierre Brochu, Jessie Ménard & Sami Haddad. (2022) Cardiopulmonary parameters and organ blood flows for workers expressed in terms of VO2 for use in physiologically based toxicokinetic modeling. Journal of Toxicology and Environmental Health, Part A 85:8, pages 307-335.
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Miyuki Breen, Caroline L Ring, Anna Kreutz, Michael-Rock Goldsmith & John F Wambaugh. (2021) High-throughput PBTK models for in vitro to in vivo extrapolation. Expert Opinion on Drug Metabolism & Toxicology 17:8, pages 903-921.
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Honesty Tohon, Andy Nong, Marjory Moreau, Mathieu Valcke & Sami Haddad. (2018) Reverse dosimetry modeling of toluene exposure concentrations based on biomonitoring levels from the Canadian health measures survey. Journal of Toxicology and Environmental Health, Part A 81:20, pages 1066-1082.
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Kannan Krishnan & Richard Carrier. (2017) A decision tree approach to screen drinking water contaminants for multiroute exposure potential in developing guideline values. Journal of Environmental Science and Health, Part C 35:3, pages 173-187.
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Gary Ginsberg, Suryanarayana V Vulimiri, Yu-Sheng Lin, Jayaram Kancherla, Brenda Foos & Babasaheb Sonawane. (2017) A framework and case studies for evaluation of enzyme ontogeny in children’s health risk evaluation. Journal of Toxicology and Environmental Health, Part A 80:10-12, pages 569-593.
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Elaina M. Kenyon, Christopher Eklund, John C. Lipscomb & Rex A. Pegram. (2016) The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM). Toxicology Mechanisms and Methods 26:8, pages 620-626.
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Axelle Marchand, Rocio Aranda-Rodriguez, Robert Tardif, Andy Nong & Sami Haddad. (2016) Evaluation and modeling of the impact of coexposures to VOC mixtures on urinary biomarkers. Inhalation Toxicology 28:6, pages 260-273.
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Mathieu Valcke & Sami Haddad. (2015) Assessing Human Variability in Kinetics for Exposures to Multiple Environmental Chemicals: A Physiologically Based Pharmacokinetic Modeling Case Study with Dichloromethane, Benzene, Toluene, Ethylbenzene, and m-Xylene. Journal of Toxicology and Environmental Health, Part A 78:7, pages 409-431.
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Mathieu Valcke & Kannan Krishnan. (2011) Assessing the impact of the duration and intensity of inhalation exposure on the magnitude of the variability of internal dose metrics in children and adults. Inhalation Toxicology 23:14, pages 863-877.
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Jennifer B Dressman, Kirstin Thelen & Stefan Willmann. (2011) An update on computational oral absorption simulation. Expert Opinion on Drug Metabolism & Toxicology 7:11, pages 1345-1364.
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Stéphane Buteau & Mathieu Valcke. (2010) Probabilistic Human Health Risk Assessment for Quarterly Exposure to High Chloroform Concentrations in Drinking-Water Distribution Network of the Province of Quebec, Canada. Journal of Toxicology and Environmental Health, Part A 73:23, pages 1626-1644.
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Agustín Llopis-González, María Morales-Suárez-Varela, Salvador Sagrado-Vives, Natalia Gimeno-Clemente, Vicent Yusà-Pelecha, Pedro Martí-Requena & Lorenzo Monforte-Monleón. (2010) Long-term characterization of trihalomethane levels in drinking water. Toxicological & Environmental Chemistry 92:4, pages 683-696.
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Irène Sari-Minodier, Ginette Truchon, Ginette Charest-Tardif, Anick Bérubé & Robert Tardif. (2009) The Effect of Workload on Biological Monitoring of Occupational Exposure to Toluene and N-Hexane: Contribution of Physiologically Based Toxicokinetic Modeling. Journal of Occupational and Environmental Hygiene 6:7, pages 415-432.
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DeborahE. Keil, MargieM. Peden-Adams, Stacy Wallace, Phillip Ruiz & GaryS. Gilkeson. (2009) Assessment of trichloroethylene (TCE) exposure in murine strains genetically-prone and non-prone to develop autoimmune disease. Journal of Environmental Science and Health, Part A 44:5, pages 443-453.
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. (2009) Letters to the Editor. Journal of Environmental Science and Health, Part A 44:1, pages 116-122.
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Kannan Krishnan & Richard Carrier. (2008) Approaches for Evaluating the Relevance of Multiroute Exposures in Establishing Guideline Values for Drinking Water Contaminants. Journal of Environmental Science and Health, Part C 26:3, pages 300-316.
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Thomas J. Luben, Rachel M. Shaffer, Elaina Kenyon, Wendy N. Nembhard, Kari A. Weber, John Nuckols & J. Michael Wright. (2023) Comparison of Trihalomethane exposure assessment metrics in epidemiologic analyses of reproductive and developmental outcomes. Journal of Exposure Science & Environmental Epidemiology 34:1, pages 115-125.
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Seung-Hyun Jeong, Ji-Hun Jang & Yong-Bok Lee. (2023) Inter-individual exposure variability interpretation through reflection of biological age algorithm in physiologically based toxicokinetic model: Application to human risk assessment of di-isobutyl-phthalate. Environmental Pollution 336, pages 122388.
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Mingnan Gao, Han Guo, Jingjing Han, Jinhua Liu, Yinglong Hou, Zimao Wang, Zheng Yang & Qiying Wang. (2023) Bromoform exposure is associated with non-melanoma skin cancer: evidence from NHANES 2011–2020. Frontiers in Public Health 11.
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Li Yang, Limei Chen, Yamei Hao, Run Zhou, Jingying Zhu, Xun Zhu, Qianqian Wang, Xiuzhu Li, Xinliang Ding & Yanhua Qian. (2023) Urinary trihalomethane concentrations and liver function indicators: a cross-sectional study in China. Environmental Science and Pollution Research 30:14, pages 39724-39732.
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R. Tardif, S. Haddad, C. Catto, G. Hamelin & M.J. Rodriguez. 2011. Encyclopedia of Environmental Health. Encyclopedia of Environmental Health 810 819 .
B.C. Blount, L.C. Backer, L.L. Aylward, S.M. Hays & J.S. LaKind. 2011. Encyclopedia of Environmental Health. Encyclopedia of Environmental Health 100 107 .
Susan D. Richardson & Cristina Postigo. 2012. Emerging Organic Contaminants and Human Health. Emerging Organic Contaminants and Human Health 93 137 .
Mathieu Valcke & Kannan Krishnan. (2010) An Assessment of the Interindividual Variability of Internal Dosimetry during Multi-Route Exposure to Drinking Water Contaminants. International Journal of Environmental Research and Public Health 7:11, pages 4002-4022.
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Lesa L. Aylward, Chris R. Kirman, Ben C. Blount & Sean M. Hays. (2010) Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs) – Application of steady-state PBPK model solutions. Regulatory Toxicology and Pharmacology 58:1, pages 33-44.
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Yuching Yang, Xu Xu & Panos G Georgopoulos. (2009) A Bayesian population PBPK model for multiroute chloroform exposure. Journal of Exposure Science & Environmental Epidemiology 20:4, pages 326-341.
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Judy S Lakind, Daniel Q Naiman, Sean M Hays, Lesa L Aylward & Benjamin C Blount. (2009) Public health interpretation of trihalomethane blood levels in the United States: NHANES 1999–2004. Journal of Exposure Science & Environmental Epidemiology 20:3, pages 255-262.
Crossref
Yu‐Mei Tan & Harvey J. ClewellIIIIII. 2010. Quantitative Modeling in Toxicology. Quantitative Modeling in Toxicology 353 369 .
Christelle Legay, Manuel J. Rodriguez, Jean B. Sérodes & Patrick Levallois. (2010) Estimation of chlorination by-products presence in drinking water in epidemiological studies on adverse reproductive outcomes: A review. Science of The Total Environment 408:3, pages 456-472.
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Crossref
Asish Mohapatra & Pertti J. Hakkinen. 2009. Information Resources in Toxicology. Information Resources in Toxicology 269 279 .
Lesa L. Aylward, Judy S. LaKind & Sean M. Hays. (2008) Biomonitoring Equivalents (BE) dossier for trihalomethanes. Regulatory Toxicology and Pharmacology 51:3, pages S68-S77.
Crossref
Harvey J. Clewell, Yu Mei Tan, Jerry L. Campbell & Melvin E. Andersen. (2008) Quantitative Interpretation of Human Biomonitoring Data. Toxicology and Applied Pharmacology 231:1, pages 122-133.
Crossref
Marc-André Verner, Michel Charbonneau, Lizbeth López-Carrillo & Sami Haddad. (2008) Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic Studies. Environmental Health Perspectives 116:7, pages 886-892.
Crossref
Teresa L. Leavens, Benjamin C. Blount, David M. DeMarini, Michael C. Madden, John L. Valentine, Martin W. Case, Lalith K. Silva, Sarah H. Warren, Nancy M. Hanley & Rex A. Pegram. (2007) Disposition of Bromodichloromethane in Humans Following Oral and Dermal Exposure. Toxicological Sciences 99:2, pages 432-445.
Crossref
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